FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977428082> ?p ?o ?g. }

• W1977428082 endingPage "650" @default.
• W1977428082 startingPage "643" @default.
• W1977428082 abstract "Phenformin is a biguanide that has been largely used in the past for its anti-diabetic activity. A large body of evidence suggests additional effects of phenformin including antitumoral activity in different animal models in vivo. Thus, the present study has been conducted in order to elucidate possible mechanisms involved in the antitumoral effects of phenformin. In various tumoral cell lines (SH-SY5Y neuroblastoma and LNCaP prostate adenocarcinoma cells), increasing concentrations of phenformin (50-500 microM) induced a concentration-dependent inhibition of cell proliferation. This effect was not dependent on the ability of the drug to reduce glucose levels and was accompanied by induction of apoptotic cell death as measured by cytofluorometric analysis. In addition, a short-time incubation of SH-SY5Y cells with phenformin induced enhanced and transient expression of the cell cycle inhibitor p21 suggesting that phenformin causes inhibition of cell cycle progression prior to induction of apoptosis. These results demonstrate an activity at the cellular level of phenformin that supports its antitumoral effect observed in vivo." @default.
• W1977428082 created "2016-06-24" @default.
• W1977428082 creator A5008484184 @default.
• W1977428082 creator A5026954701 @default.
• W1977428082 creator A5034467556 @default.
• W1977428082 creator A5068055181 @default.
• W1977428082 creator A5068147978 @default.
• W1977428082 creator A5082099245 @default.
• W1977428082 creator A5089302046 @default.
• W1977428082 creator A5089743274 @default.
• W1977428082 date "2003-12-01" @default.
• W1977428082 modified "2023-09-25" @default.
• W1977428082 title "Effects of phenformin on the proliferation of human tumor cell lines" @default.
• W1977428082 cites W149212049 @default.
• W1977428082 cites W1978025524 @default.
• W1977428082 cites W1984079395 @default.
• W1977428082 cites W1988288859 @default.
• W1977428082 cites W1991592196 @default.
• W1977428082 cites W1998770945 @default.
• W1977428082 cites W2012191027 @default.
• W1977428082 cites W2034022260 @default.
• W1977428082 cites W2056347227 @default.
• W1977428082 cites W2089167671 @default.
• W1977428082 cites W2102696959 @default.
• W1977428082 cites W2169790726 @default.
• W1977428082 cites W4293247451 @default.
• W1977428082 doi "https://doi.org/10.1016/j.lfs.2003.07.015" @default.
• W1977428082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14623034" @default.
• W1977428082 hasPublicationYear "2003" @default.
• W1977428082 type Work @default.
• W1977428082 sameAs 1977428082 @default.
• W1977428082 citedByCount "33" @default.
• W1977428082 countsByYear W19774280822012 @default.
• W1977428082 countsByYear W19774280822013 @default.
• W1977428082 countsByYear W19774280822014 @default.
• W1977428082 countsByYear W19774280822015 @default.
• W1977428082 countsByYear W19774280822017 @default.
• W1977428082 countsByYear W19774280822018 @default.
• W1977428082 countsByYear W19774280822019 @default.
• W1977428082 countsByYear W19774280822022 @default.
• W1977428082 crossrefType "journal-article" @default.
• W1977428082 hasAuthorship W1977428082A5008484184 @default.
• W1977428082 hasAuthorship W1977428082A5026954701 @default.
• W1977428082 hasAuthorship W1977428082A5034467556 @default.
• W1977428082 hasAuthorship W1977428082A5068055181 @default.
• W1977428082 hasAuthorship W1977428082A5068147978 @default.
• W1977428082 hasAuthorship W1977428082A5082099245 @default.
• W1977428082 hasAuthorship W1977428082A5089302046 @default.
• W1977428082 hasAuthorship W1977428082A5089743274 @default.
• W1977428082 hasConcept C121608353 @default.
• W1977428082 hasConcept C126322002 @default.
• W1977428082 hasConcept C134018914 @default.
• W1977428082 hasConcept C1491633281 @default.
• W1977428082 hasConcept C150903083 @default.
• W1977428082 hasConcept C185592680 @default.
• W1977428082 hasConcept C190283241 @default.
• W1977428082 hasConcept C207001950 @default.
• W1977428082 hasConcept C2776235491 @default.
• W1977428082 hasConcept C2777688063 @default.
• W1977428082 hasConcept C2778877718 @default.
• W1977428082 hasConcept C2779723316 @default.
• W1977428082 hasConcept C2780323712 @default.
• W1977428082 hasConcept C29537977 @default.
• W1977428082 hasConcept C31573885 @default.
• W1977428082 hasConcept C502942594 @default.
• W1977428082 hasConcept C54355233 @default.
• W1977428082 hasConcept C55493867 @default.
• W1977428082 hasConcept C555293320 @default.
• W1977428082 hasConcept C62112901 @default.
• W1977428082 hasConcept C71924100 @default.
• W1977428082 hasConcept C81885089 @default.
• W1977428082 hasConcept C86803240 @default.
• W1977428082 hasConcept C98274493 @default.
• W1977428082 hasConceptScore W1977428082C121608353 @default.
• W1977428082 hasConceptScore W1977428082C126322002 @default.
• W1977428082 hasConceptScore W1977428082C134018914 @default.
• W1977428082 hasConceptScore W1977428082C1491633281 @default.
• W1977428082 hasConceptScore W1977428082C150903083 @default.
• W1977428082 hasConceptScore W1977428082C185592680 @default.
• W1977428082 hasConceptScore W1977428082C190283241 @default.
• W1977428082 hasConceptScore W1977428082C207001950 @default.
• W1977428082 hasConceptScore W1977428082C2776235491 @default.
• W1977428082 hasConceptScore W1977428082C2777688063 @default.
• W1977428082 hasConceptScore W1977428082C2778877718 @default.
• W1977428082 hasConceptScore W1977428082C2779723316 @default.
• W1977428082 hasConceptScore W1977428082C2780323712 @default.
• W1977428082 hasConceptScore W1977428082C29537977 @default.
• W1977428082 hasConceptScore W1977428082C31573885 @default.
• W1977428082 hasConceptScore W1977428082C502942594 @default.
• W1977428082 hasConceptScore W1977428082C54355233 @default.
• W1977428082 hasConceptScore W1977428082C55493867 @default.
• W1977428082 hasConceptScore W1977428082C555293320 @default.
• W1977428082 hasConceptScore W1977428082C62112901 @default.
• W1977428082 hasConceptScore W1977428082C71924100 @default.
• W1977428082 hasConceptScore W1977428082C81885089 @default.
• W1977428082 hasConceptScore W1977428082C86803240 @default.
• W1977428082 hasConceptScore W1977428082C98274493 @default.
• W1977428082 hasIssue "5" @default.

• next