FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977432832> ?p ?o ?g. }

• W1977432832 endingPage "261" @default.
• W1977432832 startingPage "255" @default.
• W1977432832 abstract "The relative abundance of 7 messenger RNAs extracted from Alzheimer and control neocortex were examined by Northern and quantitative dot blot analysis. The average yield of mRNA coding for NF-L, the 68-kDa moiety of neurofilament protein, was reduced to 27% of control when expressed as the percentage of total RNA or 14% when expressed per gram of neocortex. In contrast, the yields of 6 other messenger RNAs fell into two categories: those which were statistically significantly reduced to about 65% of control and those which were not reduced when expressed as percentage of total RNA. The anomalous low abundance of neuron specific NF-L mRNA, coding for the lowest molecular weight moiety of neurofilament proteins, in cerebral cortex of Alzheimer's disease cannot be adequately accounted for by a non-specific effect of brain damage, neuron cell loss or neurons with neurofibrillary degeneration. We speculate that this mRNA decrease is related to a functional deficit of gene expression in Alzheimer's disease, perhaps related to the non-random increase in chromatin compaction previously reported from this laboratory. The inability of neurons to maintain homeostatic amounts of NF-L transcription products may be linked to the accumulation of abnormal filamentous components characteristically associated with the diseased cytoskeleton." @default.
• W1977432832 created "2016-06-24" @default.
• W1977432832 creator A5007074587 @default.
• W1977432832 creator A5034934480 @default.
• W1977432832 creator A5061360555 @default.
• W1977432832 creator A5083290510 @default.
• W1977432832 creator A5084467136 @default.
• W1977432832 date "1988-06-01" @default.
• W1977432832 modified "2023-09-26" @default.
• W1977432832 title "Selective messenger RNA reduction in Alzheimer's disease" @default.
• W1977432832 cites W1989825490 @default.
• W1977432832 cites W2014669590 @default.
• W1977432832 cites W2015533773 @default.
• W1977432832 cites W2025936600 @default.
• W1977432832 cites W2032095864 @default.
• W1977432832 cites W2032531559 @default.
• W1977432832 cites W2034969383 @default.
• W1977432832 cites W2073861859 @default.
• W1977432832 cites W2079193268 @default.
• W1977432832 cites W2081814828 @default.
• W1977432832 cites W2085408531 @default.
• W1977432832 doi "https://doi.org/10.1016/0169-328x(88)90048-4" @default.
• W1977432832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3401702" @default.
• W1977432832 hasPublicationYear "1988" @default.
• W1977432832 type Work @default.
• W1977432832 sameAs 1977432832 @default.
• W1977432832 citedByCount "78" @default.
• W1977432832 countsByYear W19774328322015 @default.
• W1977432832 countsByYear W19774328322016 @default.
• W1977432832 countsByYear W19774328322018 @default.
• W1977432832 countsByYear W19774328322019 @default.
• W1977432832 countsByYear W19774328322020 @default.
• W1977432832 countsByYear W19774328322021 @default.
• W1977432832 countsByYear W19774328322022 @default.
• W1977432832 countsByYear W19774328322023 @default.
• W1977432832 crossrefType "journal-article" @default.
• W1977432832 hasAuthorship W1977432832A5007074587 @default.
• W1977432832 hasAuthorship W1977432832A5034934480 @default.
• W1977432832 hasAuthorship W1977432832A5061360555 @default.
• W1977432832 hasAuthorship W1977432832A5083290510 @default.
• W1977432832 hasAuthorship W1977432832A5084467136 @default.
• W1977432832 hasConcept C104317684 @default.
• W1977432832 hasConcept C105580179 @default.
• W1977432832 hasConcept C126322002 @default.
• W1977432832 hasConcept C150194340 @default.
• W1977432832 hasConcept C153911025 @default.
• W1977432832 hasConcept C157207234 @default.
• W1977432832 hasConcept C169760540 @default.
• W1977432832 hasConcept C203014093 @default.
• W1977432832 hasConcept C204232928 @default.
• W1977432832 hasConcept C2776925932 @default.
• W1977432832 hasConcept C2777222312 @default.
• W1977432832 hasConcept C2778794669 @default.
• W1977432832 hasConcept C2779134260 @default.
• W1977432832 hasConcept C2781041448 @default.
• W1977432832 hasConcept C502032728 @default.
• W1977432832 hasConcept C55493867 @default.
• W1977432832 hasConcept C67705224 @default.
• W1977432832 hasConcept C71924100 @default.
• W1977432832 hasConcept C86803240 @default.
• W1977432832 hasConcept C95444343 @default.
• W1977432832 hasConceptScore W1977432832C104317684 @default.
• W1977432832 hasConceptScore W1977432832C105580179 @default.
• W1977432832 hasConceptScore W1977432832C126322002 @default.
• W1977432832 hasConceptScore W1977432832C150194340 @default.
• W1977432832 hasConceptScore W1977432832C153911025 @default.
• W1977432832 hasConceptScore W1977432832C157207234 @default.
• W1977432832 hasConceptScore W1977432832C169760540 @default.
• W1977432832 hasConceptScore W1977432832C203014093 @default.
• W1977432832 hasConceptScore W1977432832C204232928 @default.
• W1977432832 hasConceptScore W1977432832C2776925932 @default.
• W1977432832 hasConceptScore W1977432832C2777222312 @default.
• W1977432832 hasConceptScore W1977432832C2778794669 @default.
• W1977432832 hasConceptScore W1977432832C2779134260 @default.
• W1977432832 hasConceptScore W1977432832C2781041448 @default.
• W1977432832 hasConceptScore W1977432832C502032728 @default.
• W1977432832 hasConceptScore W1977432832C55493867 @default.
• W1977432832 hasConceptScore W1977432832C67705224 @default.
• W1977432832 hasConceptScore W1977432832C71924100 @default.
• W1977432832 hasConceptScore W1977432832C86803240 @default.
• W1977432832 hasConceptScore W1977432832C95444343 @default.
• W1977432832 hasIssue "3" @default.
• W1977432832 hasLocation W19774328321 @default.
• W1977432832 hasLocation W19774328322 @default.
• W1977432832 hasOpenAccess W1977432832 @default.
• W1977432832 hasPrimaryLocation W19774328321 @default.
• W1977432832 hasRelatedWork W126741730 @default.
• W1977432832 hasRelatedWork W1508632469 @default.
• W1977432832 hasRelatedWork W1526114854 @default.
• W1977432832 hasRelatedWork W1578607894 @default.
• W1977432832 hasRelatedWork W1843983222 @default.
• W1977432832 hasRelatedWork W1986336068 @default.
• W1977432832 hasRelatedWork W2057524090 @default.
• W1977432832 hasRelatedWork W2071596650 @default.
• W1977432832 hasRelatedWork W4322771665 @default.
• W1977432832 hasRelatedWork W95317953 @default.
• W1977432832 hasVolume "3" @default.
• W1977432832 isParatext "false" @default.

• next