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- W1977438857 abstract "The administration of allopurinol to rats was found to interfere with de novo pyrimidine biosynthesis, resulting in increased urinary excretion of orotic acid and orotidine and elevated activities of the enzymes orotate phosphoribosyltransferase and orotidine-5′-phosphate decarboxylase in erythrocytes. Similar increases in the liver enzymes were also observed, though it was necessary to dialyse the liver homogenates to observe an increase in the phosphoribosyltransferase. On the basis of thermal inactivation and gel filtration studies, evidence is presented that both enzymic activities reside in a single protein moiety capable of association-dissociation phenomena. Allopurinol administration resulted in the formation of an inhibitor (or inhibitors) of these enzymes. The inhibitor appeared to stabilize the enzymes by promoting the formation of higher molecular weight forms." @default.
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- W1977438857 date "1972-09-01" @default.
- W1977438857 modified "2023-09-27" @default.
- W1977438857 title "Alteration of quaternary structural behaviour of an hepatic orotate phosphoribosyltransferase-orotidine-5′-phosphate decarboxylase complex in rats following allopurinol therapy" @default.
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- W1977438857 doi "https://doi.org/10.1016/0006-2952(72)90418-2" @default.
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