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- W1977447756 abstract "Several CART (cocaine- and amphetamine-regulated transcript) peptides have been identified in the brain. One peptide, rlCART 55–102, has been previously characterized in locomotor and feeding assays in rodents. The present study characterized the locomotor-stimulating effect of several additional CART peptides after intra-VTA administration in rats. The results confirm earlier findings that intra-VTA administration of rlCART 55–102 dose-dependently increased locomotor activity. Intra-VTA administration of rlCART 62–102 increased activity comparable with that produced by rlCART 55–102. However, intra-VTA administration of rsCART 10–89 and rlCART 55–59 did not increase motor activity. These results suggest that the portion of rlCART 55–102 responsible for increasing motor activity must reside within the portion of the protein also encompassed by rlCART 61–102, as the initial 5-amino acidsequence of rlCART 55–102 did not increase motor activity. In summary, rlCART 55–102 and rlCART 62–102 arebehaviorally active in this locomotor assay, while rsCART 10–89 and rlCART 55–59 are not." @default.
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- W1977447756 date "2002-02-01" @default.
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- W1977447756 title "Activity of various CART peptides in changing locomotor activity in the rat" @default.
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- W1977447756 doi "https://doi.org/10.1054/npep.2002.0884" @default.
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