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• W1977449047 endingPage "713" @default.
• W1977449047 startingPage "697" @default.
• W1977449047 abstract "Helicases must unwind DNA at the right place and time to maintain genomic integrity or gene expression. Biologically critical XPB and XPD helicases are key members of the human TFIIH complex; they anchor CAK kinase (cyclinH, MAT1, CDK7) to TFIIH and open DNA for transcription and for repair of duplex distorting damage by nucleotide excision repair (NER). NER is initiated by arrested RNA polymerase or damage recognition by XPC–RAD23B with or without DDB1/DDB2. XP helicases, named for their role in the extreme sun-mediated skin cancer predisposition xeroderma pigmentosum (XP), are then recruited to asymmetrically unwind dsDNA flanking the damage. XPB and XPD genetic defects can also cause premature aging with profound neurological defects without increased cancers: Cockayne syndrome (CS) and trichothiodystrophy (TTD). XP helicase patient phenotypes cannot be predicted from the mutation position along the linear gene sequence and adjacent mutations can cause different diseases. Here we consider the structural biology of DNA damage recognition by XPC–RAD23B, DDB1/DDB2, RNAPII, and ATL, and of helix unwinding by the XPB and XPD helicases plus the bacterial repair helicases UvrB and UvrD in complex with DNA. We then propose unified models for TFIIH assembly and roles in NER. Collective crystal structures with NMR and electron microscopy results reveal functional motifs, domains, and architectural elements that contribute to biological activities: damaged DNA binding, translocation, unwinding, and ATP driven changes plus TFIIH assembly and signaling. Coupled with mapping of patient mutations, these combined structural analyses provide a framework for integrating and unifying the rich biochemical and cellular information that has accumulated over forty years of study. This integration resolves puzzles regarding XP helicase functions and suggests that XP helicase positions and activities within TFIIH detect and verify damage, select the damaged strand for incision, and coordinate repair with transcription and cell cycle through CAK signaling." @default.
• W1977449047 created "2016-06-24" @default.
• W1977449047 creator A5028234632 @default.
• W1977449047 creator A5059713279 @default.
• W1977449047 date "2011-07-01" @default.
• W1977449047 modified "2023-09-30" @default.
• W1977449047 title "XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase" @default.
• W1977449047 cites W1591230623 @default.
• W1977449047 cites W1599133231 @default.
• W1977449047 cites W1603476921 @default.
• W1977449047 cites W1603832006 @default.
• W1977449047 cites W1844213024 @default.
• W1977449047 cites W1886853229 @default.
• W1977449047 cites W1953968639 @default.
• W1977449047 cites W1964652890 @default.
• W1977449047 cites W1965645148 @default.
• W1977449047 cites W1966631359 @default.
• W1977449047 cites W1967288647 @default.
• W1977449047 cites W1968895302 @default.
• W1977449047 cites W1969008019 @default.
• W1977449047 cites W1969941075 @default.
• W1977449047 cites W1971159715 @default.
• W1977449047 cites W1971833279 @default.
• W1977449047 cites W1972533834 @default.
• W1977449047 cites W1973201073 @default.
• W1977449047 cites W1973268287 @default.
• W1977449047 cites W1973888214 @default.
• W1977449047 cites W1974691766 @default.
• W1977449047 cites W1975494947 @default.
• W1977449047 cites W1975695493 @default.
• W1977449047 cites W1979417055 @default.
• W1977449047 cites W1981844581 @default.
• W1977449047 cites W1982003972 @default.
• W1977449047 cites W1982138913 @default.
• W1977449047 cites W1984530381 @default.
• W1977449047 cites W1985134673 @default.
• W1977449047 cites W1987615467 @default.
• W1977449047 cites W1989317177 @default.
• W1977449047 cites W1989339075 @default.
• W1977449047 cites W1989829234 @default.
• W1977449047 cites W1990493392 @default.
• W1977449047 cites W1992082799 @default.
• W1977449047 cites W1992710359 @default.
• W1977449047 cites W1993743046 @default.
• W1977449047 cites W1994245840 @default.
• W1977449047 cites W1994561103 @default.
• W1977449047 cites W1994937498 @default.
• W1977449047 cites W1996516839 @default.
• W1977449047 cites W1996984611 @default.
• W1977449047 cites W1998261022 @default.
• W1977449047 cites W1998723823 @default.
• W1977449047 cites W1999491456 @default.
• W1977449047 cites W2000516676 @default.
• W1977449047 cites W2003482071 @default.
• W1977449047 cites W2004431479 @default.
• W1977449047 cites W2004640582 @default.
• W1977449047 cites W2005074055 @default.
• W1977449047 cites W2008466187 @default.
• W1977449047 cites W2008976303 @default.
• W1977449047 cites W2013663837 @default.
• W1977449047 cites W2014268727 @default.
• W1977449047 cites W2015725762 @default.
• W1977449047 cites W2015947721 @default.
• W1977449047 cites W2016907186 @default.
• W1977449047 cites W2019016428 @default.
• W1977449047 cites W2019502407 @default.
• W1977449047 cites W2025515800 @default.
• W1977449047 cites W2027376766 @default.
• W1977449047 cites W2027455713 @default.
• W1977449047 cites W2027481639 @default.
• W1977449047 cites W2028023155 @default.
• W1977449047 cites W2030666445 @default.
• W1977449047 cites W2030887477 @default.
• W1977449047 cites W2030900322 @default.
• W1977449047 cites W2031573266 @default.
• W1977449047 cites W2032297944 @default.
• W1977449047 cites W2032471242 @default.
• W1977449047 cites W2033741893 @default.
• W1977449047 cites W2035044845 @default.
• W1977449047 cites W2035059002 @default.
• W1977449047 cites W2035409396 @default.
• W1977449047 cites W2035438082 @default.
• W1977449047 cites W2035494017 @default.
• W1977449047 cites W2035595761 @default.
• W1977449047 cites W2036103078 @default.
• W1977449047 cites W2037936898 @default.
• W1977449047 cites W2038135691 @default.
• W1977449047 cites W2038964655 @default.
• W1977449047 cites W2039922463 @default.
• W1977449047 cites W2040033588 @default.
• W1977449047 cites W2040289024 @default.
• W1977449047 cites W2040337006 @default.
• W1977449047 cites W2040838669 @default.
• W1977449047 cites W2044000184 @default.
• W1977449047 cites W2046082575 @default.
• W1977449047 cites W2049638251 @default.
• W1977449047 cites W2050320436 @default.
• W1977449047 cites W2050570838 @default.

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