Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977454328> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1977454328 endingPage "135" @default.
- W1977454328 startingPage "129" @default.
- W1977454328 abstract "Bicuculline methobromide, a complex alkaloid, antagonizes in some unknown manner the action of GABA, an important inhibitory transmitter in the CNS. To help understand the mechanism of this antagonism we have employed molecular modeling techniques to assess the similarity and difference between this antagonist and GABA plus four direct GABA agonists. Topological and electronic charge congruence between these five molecules was examined in great detail. It was found that each of the five molecules has three clearly defined atoms that serve as attachment points at the GABAA receptor site. It is hypothesized that an additional negatively charged atom on bicuculline serves as an additional point of attachment that blocks the nearby chloride ion channel. The model presented offers an explanation of why muscimol acts as a better agonist than GABA as well as rationalizing why (+)-bicuculline acts as an antagonist but (-)-bicuculline does not." @default.
- W1977454328 created "2016-06-24" @default.
- W1977454328 creator A5008036186 @default.
- W1977454328 creator A5045018891 @default.
- W1977454328 date "1989-06-01" @default.
- W1977454328 modified "2023-09-28" @default.
- W1977454328 title "On the GABAA receptor: A molecular modeling approach" @default.
- W1977454328 cites W1965097345 @default.
- W1977454328 cites W1982432005 @default.
- W1977454328 cites W1984414399 @default.
- W1977454328 cites W1998624786 @default.
- W1977454328 cites W2027861706 @default.
- W1977454328 cites W2030020559 @default.
- W1977454328 cites W2041662125 @default.
- W1977454328 cites W2042485333 @default.
- W1977454328 cites W2052722203 @default.
- W1977454328 cites W2056945518 @default.
- W1977454328 cites W2067565788 @default.
- W1977454328 cites W2071035793 @default.
- W1977454328 cites W2082540574 @default.
- W1977454328 cites W2090776747 @default.
- W1977454328 cites W2093147008 @default.
- W1977454328 cites W2105485799 @default.
- W1977454328 cites W2169343972 @default.
- W1977454328 cites W2329898820 @default.
- W1977454328 cites W4211114348 @default.
- W1977454328 cites W604621907 @default.
- W1977454328 doi "https://doi.org/10.1002/jnr.490230202" @default.
- W1977454328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2547082" @default.
- W1977454328 hasPublicationYear "1989" @default.
- W1977454328 type Work @default.
- W1977454328 sameAs 1977454328 @default.
- W1977454328 citedByCount "24" @default.
- W1977454328 crossrefType "journal-article" @default.
- W1977454328 hasAuthorship W1977454328A5008036186 @default.
- W1977454328 hasAuthorship W1977454328A5045018891 @default.
- W1977454328 hasConcept C12554922 @default.
- W1977454328 hasConcept C168258287 @default.
- W1977454328 hasConcept C169760540 @default.
- W1977454328 hasConcept C170493617 @default.
- W1977454328 hasConcept C185592680 @default.
- W1977454328 hasConcept C2776885963 @default.
- W1977454328 hasConcept C2778938600 @default.
- W1977454328 hasConcept C2779188335 @default.
- W1977454328 hasConcept C2780763569 @default.
- W1977454328 hasConcept C55493867 @default.
- W1977454328 hasConcept C71240020 @default.
- W1977454328 hasConcept C79636183 @default.
- W1977454328 hasConcept C86803240 @default.
- W1977454328 hasConcept C98274493 @default.
- W1977454328 hasConceptScore W1977454328C12554922 @default.
- W1977454328 hasConceptScore W1977454328C168258287 @default.
- W1977454328 hasConceptScore W1977454328C169760540 @default.
- W1977454328 hasConceptScore W1977454328C170493617 @default.
- W1977454328 hasConceptScore W1977454328C185592680 @default.
- W1977454328 hasConceptScore W1977454328C2776885963 @default.
- W1977454328 hasConceptScore W1977454328C2778938600 @default.
- W1977454328 hasConceptScore W1977454328C2779188335 @default.
- W1977454328 hasConceptScore W1977454328C2780763569 @default.
- W1977454328 hasConceptScore W1977454328C55493867 @default.
- W1977454328 hasConceptScore W1977454328C71240020 @default.
- W1977454328 hasConceptScore W1977454328C79636183 @default.
- W1977454328 hasConceptScore W1977454328C86803240 @default.
- W1977454328 hasConceptScore W1977454328C98274493 @default.
- W1977454328 hasIssue "2" @default.
- W1977454328 hasLocation W19774543281 @default.
- W1977454328 hasLocation W19774543282 @default.
- W1977454328 hasOpenAccess W1977454328 @default.
- W1977454328 hasPrimaryLocation W19774543281 @default.
- W1977454328 hasRelatedWork W186582574 @default.
- W1977454328 hasRelatedWork W1948082071 @default.
- W1977454328 hasRelatedWork W1980055752 @default.
- W1977454328 hasRelatedWork W1988704090 @default.
- W1977454328 hasRelatedWork W1990800320 @default.
- W1977454328 hasRelatedWork W1998870963 @default.
- W1977454328 hasRelatedWork W2022245903 @default.
- W1977454328 hasRelatedWork W2026707293 @default.
- W1977454328 hasRelatedWork W2114089489 @default.
- W1977454328 hasRelatedWork W2404125743 @default.
- W1977454328 hasVolume "23" @default.
- W1977454328 isParatext "false" @default.
- W1977454328 isRetracted "false" @default.
- W1977454328 magId "1977454328" @default.
- W1977454328 workType "article" @default.