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- W1977457974 abstract "The term “epigenetics” was first introduced by Conrad Waddington in 1942 to describe “the interactions of genes with their environment, which bring the phenotype into being.”1 Later that same decade came the identification and characterization of DNA methylation,2 the first epigenetic mark to be discovered. The major target for DNA methylation in the mammalian genome is cytosine, where enzymatic attachment of a methyl group to the 5 position of the pyrimidine ring produces 5-methylcytosine,3 which has been referred to as the fifth base of genomic DNA." @default.
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- W1977457974 date "2006-05-01" @default.
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- W1977457974 title "Quantitative DNA Methylation Analysis: The Promise of High-Throughput Epigenomic Diagnostic Testing in Human Neoplastic Disease" @default.
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- W1977457974 doi "https://doi.org/10.2353/jmoldx.2006.060026" @default.
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