FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977464493> ?p ?o ?g. }

• W1977464493 endingPage "3153" @default.
• W1977464493 startingPage "3145" @default.
• W1977464493 abstract "Photoreceptor proteins play crucial roles in receiving light stimuli that give rise to the responses required for biological function. However, structural characterization of conformational transition of the photoreceptors has been elusive in their native aqueous environment, even for a prototype photoreceptor, photoactive yellow protein (PYP). We employ pump-probe X-ray solution scattering to probe the structural changes that occur during the photocycle of PYP in a wide time range from 3.16 μs to 300 ms. By the analysis of both kinetics and structures of the intermediates, the structural progression of the protein in the solution phase is vividly visualized. We identify four structurally distinct intermediates and their associated five time constants and reconstructed the molecular shapes of the four intermediates from time-independent, species-associated difference scattering curves. The reconstructed structures of the intermediates show the large conformational changes such as the protrusion of N-terminus, which is restricted in the crystalline phase due to the crystal contact and thus could not be clearly observed by X-ray crystallography. The protrusion of the N-terminus and the protein volume gradually increase with the progress of the photocycle and becomes maximal in the final intermediate, which is proposed to be the signaling state. The data not only reveal that a common kinetic mechanism is applicable to both the crystalline and the solution phases, but also provide direct evidence for how the sample environment influences structural dynamics and the reaction rates of the PYP photocycle." @default.
• W1977464493 created "2016-06-24" @default.
• W1977464493 creator A5004682153 @default.
• W1977464493 creator A5012770069 @default.
• W1977464493 creator A5017519850 @default.
• W1977464493 creator A5033227759 @default.
• W1977464493 creator A5042669825 @default.
• W1977464493 creator A5042775709 @default.
• W1977464493 creator A5049129395 @default.
• W1977464493 creator A5049940179 @default.
• W1977464493 creator A5050472874 @default.
• W1977464493 creator A5055037842 @default.
• W1977464493 creator A5060464579 @default.
• W1977464493 creator A5064396978 @default.
• W1977464493 creator A5070800561 @default.
• W1977464493 date "2012-02-03" @default.
• W1977464493 modified "2023-10-16" @default.
• W1977464493 title "Protein Structural Dynamics of Photoactive Yellow Protein in Solution Revealed by Pump–Probe X-ray Solution Scattering" @default.
• W1977464493 cites W1480246622 @default.
• W1977464493 cites W1500927176 @default.
• W1977464493 cites W1975260546 @default.
• W1977464493 cites W1977038370 @default.
• W1977464493 cites W1984530381 @default.
• W1977464493 cites W1984726770 @default.
• W1977464493 cites W1988129969 @default.
• W1977464493 cites W2006058557 @default.
• W1977464493 cites W2006706793 @default.
• W1977464493 cites W2012706554 @default.
• W1977464493 cites W2017073286 @default.
• W1977464493 cites W2017188882 @default.
• W1977464493 cites W2017509243 @default.
• W1977464493 cites W2022857836 @default.
• W1977464493 cites W2024601154 @default.
• W1977464493 cites W2025675013 @default.
• W1977464493 cites W2027659453 @default.
• W1977464493 cites W2028100864 @default.
• W1977464493 cites W2046975888 @default.
• W1977464493 cites W2048298876 @default.
• W1977464493 cites W2049526049 @default.
• W1977464493 cites W2049740050 @default.
• W1977464493 cites W2050091361 @default.
• W1977464493 cites W2050216729 @default.
• W1977464493 cites W2054492345 @default.
• W1977464493 cites W2057517712 @default.
• W1977464493 cites W2063661713 @default.
• W1977464493 cites W2066088601 @default.
• W1977464493 cites W2066415066 @default.
• W1977464493 cites W2069793801 @default.
• W1977464493 cites W2070911406 @default.
• W1977464493 cites W2072674961 @default.
• W1977464493 cites W2074849251 @default.
• W1977464493 cites W2076077658 @default.
• W1977464493 cites W2091905983 @default.
• W1977464493 cites W2092441650 @default.
• W1977464493 cites W2097446053 @default.
• W1977464493 cites W2100869615 @default.
• W1977464493 cites W2101439900 @default.
• W1977464493 cites W2104245953 @default.
• W1977464493 cites W2104903836 @default.
• W1977464493 cites W2105645728 @default.
• W1977464493 cites W2113227718 @default.
• W1977464493 cites W2113842136 @default.
• W1977464493 cites W2116490880 @default.
• W1977464493 cites W2122178630 @default.
• W1977464493 cites W2122261036 @default.
• W1977464493 cites W2125783447 @default.
• W1977464493 cites W2139702264 @default.
• W1977464493 cites W2142583555 @default.
• W1977464493 cites W2151082578 @default.
• W1977464493 cites W2151971205 @default.
• W1977464493 cites W2157268584 @default.
• W1977464493 cites W2162942780 @default.
• W1977464493 cites W2165385023 @default.
• W1977464493 cites W2949899388 @default.
• W1977464493 cites W2952053429 @default.
• W1977464493 cites W3026809886 @default.
• W1977464493 doi "https://doi.org/10.1021/ja210435n" @default.
• W1977464493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22304441" @default.
• W1977464493 hasPublicationYear "2012" @default.
• W1977464493 type Work @default.
• W1977464493 sameAs 1977464493 @default.
• W1977464493 citedByCount "95" @default.
• W1977464493 countsByYear W19774644932012 @default.
• W1977464493 countsByYear W19774644932013 @default.
• W1977464493 countsByYear W19774644932014 @default.
• W1977464493 countsByYear W19774644932015 @default.
• W1977464493 countsByYear W19774644932016 @default.
• W1977464493 countsByYear W19774644932017 @default.
• W1977464493 countsByYear W19774644932018 @default.
• W1977464493 countsByYear W19774644932019 @default.
• W1977464493 countsByYear W19774644932020 @default.
• W1977464493 countsByYear W19774644932021 @default.
• W1977464493 countsByYear W19774644932022 @default.
• W1977464493 countsByYear W19774644932023 @default.
• W1977464493 crossrefType "journal-article" @default.
• W1977464493 hasAuthorship W1977464493A5004682153 @default.
• W1977464493 hasAuthorship W1977464493A5012770069 @default.
• W1977464493 hasAuthorship W1977464493A5017519850 @default.

• next