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- W1977465540 abstract "The mammalian organism is comprised of tissue types with varying degrees of self-renewal and regenerative capacity. In most organs self-renewing tissue-specific stem and progenitor cells contribute to organ maintenance, and it is vital to maintain a functional stem cell pool to preserve organ homeostasis. Various conditions like tissue injury, stress responses, and regeneration challenge the stem cell pool to re-establish homeostasis (Fig. 1). However, with increasing age the functionality of adult stem cells declines and genomic mutations accumulate. These defects affect different cellular response pathways and lead to impairments in regeneration, stress tolerance, and organ function as well as to an increased risk for the development of ageing associated diseases and cancer. Maintenance of the genome appears to be of utmost importance to preserve stem cell function and to reduce the risk of ageing associated dysfunctions and pathologies. In this review, we discuss the causal link between stem cell dysfunction and DNA damage accrual, different strategies how stem cells maintain genome integrity, and how these processes are affected during ageing." @default.
- W1977465540 created "2016-06-24" @default.
- W1977465540 creator A5010905874 @default.
- W1977465540 creator A5036859023 @default.
- W1977465540 creator A5053296448 @default.
- W1977465540 date "2015-09-01" @default.
- W1977465540 modified "2023-10-17" @default.
- W1977465540 title "Genome instability of ageing stem cells—Induction and defence mechanisms" @default.
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