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• W1977471330 abstract "Extensive analysis of nuclear bound estrogen receptor complexes (RnE) demonstrated the presence of two high affinity binding sites: Kd, 0.10–0.20 nM and 2–4 nM, respectively. The high affinity complex constitutes about 30% of the total quantity of nuclear bound complexes. In addition two types of binding sites for RnE complexes were demonstrated by the resistance of RnE complexes to salt extraction by 0.4 M KCl. Immature rats were injected with estradiol and at various times after the injection the uteri were removed, homogenized and fractionated. The quantities of estrogen-receptor complexes in the cytosol (Re), in 0.4 M KCl-extracts of the nuclear pellets (Rn-extractable) and in the nuclear pellet after KCl-extraction (Rn-resistant) were determined. Rc rapidly declined during the first 30 min and then increased slowly over the next two h. Rn-extractable increased rapidly during the first 20 min after injection and then dropped to control levels over the following 160min. Rn-resistant increased slowly reaching a maximum after 60 min and then declining slowly during the subsequent 120 min. When uterine nuclear fractions from rats treated with 2.5μg of estradiol l h prior to sacrifice, were assayed for the quantity of receptor-steroid complexes, it was found that they contained about 5-6 times the amount found in the corresponding fraction from rats treated with 0.1 μg. About 80% of the receptor-hormone complexes found in the nucleus after injection of the high dose of estrogen was extractable by 0.4 M KCl, whereas the corresponding figure after the low dose treatment was approx. 50%. These results show the presence of two classes of receptor-estradiol complexes with different affinities for the hormone. Both classes of complexes exist in the nucleus partly as KCl-extractable and partly as KCl-resistant. The shift from Rn-extractable to Rn-resistant form might reflect changes in the conformation of the RnE complexes upon association with specific acceptor sites." @default.
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• W1977471330 date "1976-11-01" @default.
• W1977471330 modified "2023-09-26" @default.
• W1977471330 title "Uterine receptor-estradiol complexes and their interaction with nuclear binding sites" @default.
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• W1977471330 doi "https://doi.org/10.1016/0022-4731(76)90031-5" @default.
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