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- W1977481529 abstract "Granulocyte-monocyte colony-stimulating factor (GM-CSF) regulates the function of antigen-presenting cells (APCs) and has been broadly used as the adjuvant. Here, we tested whether intranasal delivery of GM-CSF can improve the contraception of mouse zona pellucida 3 (mZP3) DNA vaccine. Our results showed that co-administration of GM-CSF and mZP3 DNA vaccine increased the levels of secretory IgA (sIgA) and IgG antibodies in vaginal washes and serum, respectively. Co-administration enhanced Th2 responses through improving the maturation of dendritic cells. Importantly, GM-CSF significantly reduced the fertility rate and mean litter size induced by mZP3 DNA vaccine alone without interfering the normal follicular development. These data suggest that GM-CSF could be used as adjuvant to develop immunocontraceptive vaccine." @default.
- W1977481529 created "2016-06-24" @default.
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- W1977481529 date "2012-11-07" @default.
- W1977481529 modified "2023-09-26" @default.
- W1977481529 title "Intranasal Co-delivery with the Mouse Zona Pellucida 3 and GM-CSF Expressing Constructs Enhances Humoral Immune Responses and Contraception in Mice" @default.
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- W1977481529 doi "https://doi.org/10.1111/j.1365-3083.2012.02765.x" @default.
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