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- W1977490744 abstract "Background: Abnormal thyroid status has been reported in cystic fibrosis (CF) patients, and this can possibly be correlated to neuromuscular symptoms. Iodothyronine deiodinase type 1 (D1) activity is an important determinant of thyroid status, and we chose to investigate D1 activity in CF liver. Methods: We have measured hepatic D1 activities in two ΔF508 CF mouse models. Results: Hepatic D1 activity was significantly reduced by 31% to 48% in homozygous ΔF508 mice compared with wild-type genotypes. Conclusions: A decreased hepatic D1 activity could be the biochemical basis of some of the abnormal thyroid parameters observed in cystic fibrosis patients." @default.
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- W1977490744 date "2004-06-01" @default.
- W1977490744 modified "2023-10-11" @default.
- W1977490744 title "Hepatic iodothyronine deiodinase type 1 activity is decreased in two ΔF508 cystic fibrosis mouse models" @default.
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- W1977490744 doi "https://doi.org/10.1016/j.jcf.2004.02.002" @default.
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