Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977493485> ?p ?o ?g. }
- W1977493485 endingPage "1544" @default.
- W1977493485 startingPage "1531" @default.
- W1977493485 abstract "McArdle disease is arguably the paradigm of exercise intolerance in humans. This disorder is caused by inherited deficiency of myophosphorylase, the enzyme isoform that initiates glycogen breakdown in skeletal muscles. Because patients are unable to obtain energy from their muscle glycogen stores, this disease provides an interesting model of study for exercise physiologists, allowing insight to be gained into the understanding of glycogen-dependent muscle functions. Of special interest in the field of muscle physiology and sports medicine are also some specific (if not unique) characteristics of this disorder, such as the so-called 'second wind' phenomenon, the frequent exercise-induced rhabdomyolysis and myoglobinuria episodes suffered by patients (with muscle damage also occurring under basal conditions), or the early appearance of fatigue and contractures, among others. In this article we review the main pathophysiological features of this disorder leading to exercise intolerance as well as the currently available therapeutic possibilities. Patients have been traditionally advised by clinicians to refrain from exercise, yet sports medicine and careful exercise prescription are their best allies at present because no effective enzyme replacement therapy is expected to be available in the near future. As of today, although unable to restore myophosphorylase deficiency, the 'simple' use of exercise as therapy seems probably more promising and practical for patients than more 'complex' medical approaches." @default.
- W1977493485 created "2016-06-24" @default.
- W1977493485 creator A5000183484 @default.
- W1977493485 creator A5000772711 @default.
- W1977493485 creator A5042026086 @default.
- W1977493485 creator A5046918434 @default.
- W1977493485 creator A5052290939 @default.
- W1977493485 creator A5062240154 @default.
- W1977493485 creator A5064696668 @default.
- W1977493485 date "2014-07-16" @default.
- W1977493485 modified "2023-10-14" @default.
- W1977493485 title "McArdle Disease: A Unique Study Model in Sports Medicine" @default.
- W1977493485 cites W12318411 @default.
- W1977493485 cites W1491399076 @default.
- W1977493485 cites W1520045275 @default.
- W1977493485 cites W1556485756 @default.
- W1977493485 cites W1558831010 @default.
- W1977493485 cites W1560575497 @default.
- W1977493485 cites W1601262489 @default.
- W1977493485 cites W1799278215 @default.
- W1977493485 cites W1923002492 @default.
- W1977493485 cites W1923443500 @default.
- W1977493485 cites W1964166213 @default.
- W1977493485 cites W1966493859 @default.
- W1977493485 cites W1966630957 @default.
- W1977493485 cites W1968543180 @default.
- W1977493485 cites W1972672156 @default.
- W1977493485 cites W1973527196 @default.
- W1977493485 cites W1974431892 @default.
- W1977493485 cites W1979208993 @default.
- W1977493485 cites W1979295547 @default.
- W1977493485 cites W1979886328 @default.
- W1977493485 cites W1983666239 @default.
- W1977493485 cites W1987078011 @default.
- W1977493485 cites W1987910700 @default.
- W1977493485 cites W1989046922 @default.
- W1977493485 cites W1990085166 @default.
- W1977493485 cites W1991923018 @default.
- W1977493485 cites W1993394316 @default.
- W1977493485 cites W1993872975 @default.
- W1977493485 cites W1994774399 @default.
- W1977493485 cites W1995165799 @default.
- W1977493485 cites W1995953387 @default.
- W1977493485 cites W1996726904 @default.
- W1977493485 cites W1999171416 @default.
- W1977493485 cites W2004011563 @default.
- W1977493485 cites W2006934277 @default.
- W1977493485 cites W2007541776 @default.
- W1977493485 cites W2014231500 @default.
- W1977493485 cites W2016932647 @default.
- W1977493485 cites W2017399460 @default.
- W1977493485 cites W2020185899 @default.
- W1977493485 cites W2020516012 @default.
- W1977493485 cites W2022252518 @default.
- W1977493485 cites W2023787894 @default.
- W1977493485 cites W2024771461 @default.
- W1977493485 cites W2035221162 @default.
- W1977493485 cites W2035376430 @default.
- W1977493485 cites W2038055643 @default.
- W1977493485 cites W2039106480 @default.
- W1977493485 cites W2040334073 @default.
- W1977493485 cites W2041272135 @default.
- W1977493485 cites W2044788277 @default.
- W1977493485 cites W2044813834 @default.
- W1977493485 cites W2045720272 @default.
- W1977493485 cites W2047451833 @default.
- W1977493485 cites W2048406598 @default.
- W1977493485 cites W2051340649 @default.
- W1977493485 cites W2051981755 @default.
- W1977493485 cites W2054073593 @default.
- W1977493485 cites W2054359635 @default.
- W1977493485 cites W2054995552 @default.
- W1977493485 cites W2055269309 @default.
- W1977493485 cites W2055498548 @default.
- W1977493485 cites W2056174483 @default.
- W1977493485 cites W2057127647 @default.
- W1977493485 cites W2057487881 @default.
- W1977493485 cites W2057646264 @default.
- W1977493485 cites W2058920539 @default.
- W1977493485 cites W2059031250 @default.
- W1977493485 cites W2065308337 @default.
- W1977493485 cites W2069289373 @default.
- W1977493485 cites W2069529460 @default.
- W1977493485 cites W2069582574 @default.
- W1977493485 cites W2069684011 @default.
- W1977493485 cites W2070892016 @default.
- W1977493485 cites W2072619323 @default.
- W1977493485 cites W2072790997 @default.
- W1977493485 cites W2073130928 @default.
- W1977493485 cites W2074127662 @default.
- W1977493485 cites W2079923974 @default.
- W1977493485 cites W2080344375 @default.
- W1977493485 cites W2085235189 @default.
- W1977493485 cites W2085811948 @default.
- W1977493485 cites W2086720703 @default.
- W1977493485 cites W2092817515 @default.
- W1977493485 cites W2096759707 @default.
- W1977493485 cites W2096926851 @default.