Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977507384> ?p ?o ?g. }
- W1977507384 endingPage "23" @default.
- W1977507384 startingPage "11" @default.
- W1977507384 abstract "Hanahan and Weinberg have proposed the ‘hallmarks of cancer’ to cover the biological changes required for the development and persistence of tumours [Hanahan and Weinberg (2011) Cell 144, 646–674]. We have noted that many of these cancer hallmarks are facilitated by the multifunctional protein YB-1 (Y-box-binding protein 1). In the present review we evaluate the literature and show how YB-1 modulates/regulates cellular signalling pathways within each of these hallmarks. For example, we describe how YB-1 regulates multiple proliferation pathways, overrides cell-cycle check points, promotes replicative immortality and genomic instability, may regulate angiogenesis, has a role in invasion and metastasis, and promotes inflammation. We also argue that there is strong and sufficient evidence to suggest that YB-1 is an excellent molecular marker of cancer progression that could be used in the clinic, and that YB-1 could be a useful target for cancer therapy." @default.
- W1977507384 created "2016-06-24" @default.
- W1977507384 creator A5029629862 @default.
- W1977507384 creator A5052250296 @default.
- W1977507384 creator A5073718839 @default.
- W1977507384 creator A5078502555 @default.
- W1977507384 creator A5079814428 @default.
- W1977507384 date "2012-12-07" @default.
- W1977507384 modified "2023-10-02" @default.
- W1977507384 title "YB-1: oncoprotein, prognostic marker and therapeutic target?" @default.
- W1977507384 cites W1484020898 @default.
- W1977507384 cites W1533021978 @default.
- W1977507384 cites W1538419182 @default.
- W1977507384 cites W1545398558 @default.
- W1977507384 cites W1556824391 @default.
- W1977507384 cites W1582325190 @default.
- W1977507384 cites W1615956160 @default.
- W1977507384 cites W1964212105 @default.
- W1977507384 cites W1965232244 @default.
- W1977507384 cites W1965301111 @default.
- W1977507384 cites W1965420893 @default.
- W1977507384 cites W1966629425 @default.
- W1977507384 cites W1967980682 @default.
- W1977507384 cites W1969964320 @default.
- W1977507384 cites W1973585083 @default.
- W1977507384 cites W1974794868 @default.
- W1977507384 cites W1980396381 @default.
- W1977507384 cites W1980794648 @default.
- W1977507384 cites W1982166284 @default.
- W1977507384 cites W1982219839 @default.
- W1977507384 cites W1983123225 @default.
- W1977507384 cites W1984692764 @default.
- W1977507384 cites W1986076152 @default.
- W1977507384 cites W1988723429 @default.
- W1977507384 cites W1990893634 @default.
- W1977507384 cites W1992112921 @default.
- W1977507384 cites W1992519649 @default.
- W1977507384 cites W1992782721 @default.
- W1977507384 cites W1992885568 @default.
- W1977507384 cites W1994855284 @default.
- W1977507384 cites W1995480433 @default.
- W1977507384 cites W1996494247 @default.
- W1977507384 cites W1998462518 @default.
- W1977507384 cites W1999245993 @default.
- W1977507384 cites W2000608709 @default.
- W1977507384 cites W2002143651 @default.
- W1977507384 cites W2002277974 @default.
- W1977507384 cites W2003171179 @default.
- W1977507384 cites W2003239757 @default.
- W1977507384 cites W2003409252 @default.
- W1977507384 cites W2005113904 @default.
- W1977507384 cites W2005260875 @default.
- W1977507384 cites W2006499430 @default.
- W1977507384 cites W2007951687 @default.
- W1977507384 cites W2009886463 @default.
- W1977507384 cites W2011813310 @default.
- W1977507384 cites W2013829707 @default.
- W1977507384 cites W2019675345 @default.
- W1977507384 cites W2020547407 @default.
- W1977507384 cites W2020914260 @default.
- W1977507384 cites W2021701297 @default.
- W1977507384 cites W2021981738 @default.
- W1977507384 cites W2024105041 @default.
- W1977507384 cites W2026690365 @default.
- W1977507384 cites W2027509505 @default.
- W1977507384 cites W2028897202 @default.
- W1977507384 cites W2029035269 @default.
- W1977507384 cites W2029231027 @default.
- W1977507384 cites W2030902700 @default.
- W1977507384 cites W2034269086 @default.
- W1977507384 cites W2035731426 @default.
- W1977507384 cites W2036008499 @default.
- W1977507384 cites W2036638105 @default.
- W1977507384 cites W2040655748 @default.
- W1977507384 cites W2040988771 @default.
- W1977507384 cites W2041115282 @default.
- W1977507384 cites W2042965279 @default.
- W1977507384 cites W2045432750 @default.
- W1977507384 cites W2046821312 @default.
- W1977507384 cites W2047446484 @default.
- W1977507384 cites W2048255587 @default.
- W1977507384 cites W2048372727 @default.
- W1977507384 cites W2049087499 @default.
- W1977507384 cites W2051233997 @default.
- W1977507384 cites W2052660171 @default.
- W1977507384 cites W2053178768 @default.
- W1977507384 cites W2054557456 @default.
- W1977507384 cites W2055802531 @default.
- W1977507384 cites W2056530510 @default.
- W1977507384 cites W2057597572 @default.
- W1977507384 cites W2059763273 @default.
- W1977507384 cites W2060683243 @default.
- W1977507384 cites W2061780077 @default.
- W1977507384 cites W2063107060 @default.
- W1977507384 cites W2063845207 @default.
- W1977507384 cites W2064854415 @default.
- W1977507384 cites W2065716393 @default.
- W1977507384 cites W2066783138 @default.