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- W1977510188 abstract "In the mouse, there are two forms of X chromosome inactivation (XCI), random XCI in the fetus and imprinted paternal XCI, which is limited to the extraembryonic tissues. While the mechanism of random XCI has been studied extensively using the in vitro XX ES cell differentiation system, imprinted XCI during early embryonic development has been less well characterized. Recent studies of early embryos have reported unexpected findings for the paternal X chromosome (Xp). Imprinted XCI may not be linked to meiotic silencing in the male germ line but rather to the imprinted status of the Xist gene. Furthermore, the Xp becomes inactivated in all cells of cleavage-stage embryos and then reactivated in the cells of the inner cell mass (ICM) that form the epiblast, where random XCI ensues." @default.
- W1977510188 created "2016-06-24" @default.
- W1977510188 creator A5018287271 @default.
- W1977510188 creator A5052026543 @default.
- W1977510188 date "2006-01-01" @default.
- W1977510188 modified "2023-09-25" @default.
- W1977510188 title "The dynamics of imprinted X inactivation during preimplantation development in mice" @default.
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- W1977510188 doi "https://doi.org/10.1159/000090848" @default.
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