Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977514478> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W1977514478 endingPage "S177" @default.
- W1977514478 startingPage "S177" @default.
- W1977514478 abstract "Background: Hypertension (HT) is associated with left ventricular (LV) diastolic dysfunction and increased left atrial (LA) volume. We sought to investigate changes in LA size and function by decade in mild HT patients. Methods: Mild HT patients (31-84 years; n = 115) with blood pressure of >140/90 mm Hg but < 160/100 mmHg were compared to a case controlled normal cohort. Subjects were divided by age deciles. LA maximum, minimum and pre ‘a’ wave volumes were measured using the biplane method of discs. LA passive emptying and active emptying volumes and fractions were calculated. Results: The HT group had higher LA maximum volumes compared to Normals until decade 8. There was no difference between HT and Normal groups for passive emptying volumes, whilst active emptying volumes were higher in all decades in the HT group.Tabled 1Decade 4 (n = 11)Decade 5 (n = 24)Decade 6 (n = 30)Decade 7 (n = 31)Decade 8 (n = 19)LA max vol (ml/m2) Normal20.7 ± 3.422.3 ± 4.921.2 ± 3.922.9 ± 5.025.6 ± 6.1 HT27.3 ± 5.3*p<0.05 compared to normals.26.4 ± 7.1*p<0.05 compared to normals.25.8 ± 7.7*p<0.05 compared to normals.27.7 ± 7.3*p<0.05 compared to normals.29.3 ± 10.9Active emptying vol (ml/ m2) Normal3.9 ± 1.54.7 ± 2.04.8 ± 1.75.6 ± 1.26.5 ± 2.0 HT7.6 ± 4.3*p<0.05 compared to normals.7.0 ± 2.6*p<0.05 compared to normals.7.4 ± 2.8*p<0.05 compared to normals.8.1 ± 4.1 *p<0.05 compared to normals.9.5 ± 3.2*p<0.05 compared to normals.* p < 0.05 compared to normals. Open table in a new tab Conclusion: Even mild HT alters atrial dynamics with resultant LA enlargement and increased active emptying volumes consequent to alterations in LV diastolic function. HT accelerates the normal aging process such that patients as early as decade 4 have similar LA size to normals in decade 8. This persistent LA enlargement may lead to the development of atrial fibrillation at an earlier age even in patients with mild HT." @default.
- W1977514478 created "2016-06-24" @default.
- W1977514478 creator A5014197096 @default.
- W1977514478 creator A5018249444 @default.
- W1977514478 creator A5027348897 @default.
- W1977514478 creator A5032578857 @default.
- W1977514478 creator A5046452701 @default.
- W1977514478 date "2011-01-01" @default.
- W1977514478 modified "2023-10-07" @default.
- W1977514478 title "Hypertension Accelerates Diastolic Changes Associated with Normal Aging with a Consequent Premature Increase in Left Atrial Volumes" @default.
- W1977514478 doi "https://doi.org/10.1016/j.hlc.2011.05.438" @default.
- W1977514478 hasPublicationYear "2011" @default.
- W1977514478 type Work @default.
- W1977514478 sameAs 1977514478 @default.
- W1977514478 citedByCount "0" @default.
- W1977514478 crossrefType "journal-article" @default.
- W1977514478 hasAuthorship W1977514478A5014197096 @default.
- W1977514478 hasAuthorship W1977514478A5018249444 @default.
- W1977514478 hasAuthorship W1977514478A5027348897 @default.
- W1977514478 hasAuthorship W1977514478A5032578857 @default.
- W1977514478 hasAuthorship W1977514478A5046452701 @default.
- W1977514478 hasBestOaLocation W19775144781 @default.
- W1977514478 hasConcept C126322002 @default.
- W1977514478 hasConcept C164705383 @default.
- W1977514478 hasConcept C2778198053 @default.
- W1977514478 hasConcept C2780829959 @default.
- W1977514478 hasConcept C57900726 @default.
- W1977514478 hasConcept C71924100 @default.
- W1977514478 hasConcept C78085059 @default.
- W1977514478 hasConcept C84393581 @default.
- W1977514478 hasConceptScore W1977514478C126322002 @default.
- W1977514478 hasConceptScore W1977514478C164705383 @default.
- W1977514478 hasConceptScore W1977514478C2778198053 @default.
- W1977514478 hasConceptScore W1977514478C2780829959 @default.
- W1977514478 hasConceptScore W1977514478C57900726 @default.
- W1977514478 hasConceptScore W1977514478C71924100 @default.
- W1977514478 hasConceptScore W1977514478C78085059 @default.
- W1977514478 hasConceptScore W1977514478C84393581 @default.
- W1977514478 hasLocation W19775144781 @default.
- W1977514478 hasOpenAccess W1977514478 @default.
- W1977514478 hasPrimaryLocation W19775144781 @default.
- W1977514478 hasRelatedWork W1996893369 @default.
- W1977514478 hasRelatedWork W2001193232 @default.
- W1977514478 hasRelatedWork W2035804460 @default.
- W1977514478 hasRelatedWork W2059312764 @default.
- W1977514478 hasRelatedWork W2094197268 @default.
- W1977514478 hasRelatedWork W2471839445 @default.
- W1977514478 hasRelatedWork W2603456456 @default.
- W1977514478 hasRelatedWork W2996098296 @default.
- W1977514478 hasRelatedWork W4210909522 @default.
- W1977514478 hasRelatedWork W4361763982 @default.
- W1977514478 hasVolume "20" @default.
- W1977514478 isParatext "false" @default.
- W1977514478 isRetracted "false" @default.
- W1977514478 magId "1977514478" @default.
- W1977514478 workType "article" @default.