FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977516874> ?p ?o ?g. }

• W1977516874 endingPage "1191" @default.
• W1977516874 startingPage "1179" @default.
• W1977516874 abstract "gamma-Aminobutyric acid type A (GABA(A)) receptor alpha5 subunits, which are heavily expressed in the hippocampus, are potential drug targets for improving cognitive function. They are found at synaptic and extrasynaptic sites and have been shown to mediate tonic inhibition in pyramidal neurons. We tested the hypothesis that alpha5 subunits also contribute to synaptic inhibition by measuring the effect of diazepam (DZ) on spontaneous and stimulus-evoked inhibitory postsynaptic currents (IPSCs) in genetically modified mice carrying a point mutation in the alpha5 subunit (alpha5-H105R) that renders those receptors insensitive to benzodiazepines. In wild type mice, DZ (1 microM) increased the amplitude of spontaneous IPSCs (sIPSCs) and stimulus-evoked GABA(A,slow) IPSCs (eIPSCs) and prolonged the decay of GABA(A,fast) sIPSCs. In alpha5-mutant mice, DZ increased the amplitude of a small-amplitude subset of sIPSCs (<50 pA) and eIPSCs (<300 pA) GABA(A,slow) and prolonged the decay of GABA(A,fast) sIPSCs, but failed to increase the amplitude of larger sIPSCs and eIPSCs GABA(A,slow). These results indicate that alpha5 subunits contribute to a large-amplitude subset of GABA(A,slow) synapses and implicate these synapses in modulation of cognitive function by drugs that target alpha5 subunits." @default.
• W1977516874 created "2016-06-24" @default.
• W1977516874 creator A5028902971 @default.
• W1977516874 creator A5036255755 @default.
• W1977516874 creator A5045174992 @default.
• W1977516874 creator A5087838557 @default.
• W1977516874 date "2009-03-01" @default.
• W1977516874 modified "2023-09-28" @default.
• W1977516874 title "GABA_A Receptor α5 Subunits Contribute to GABA_A,slow Synaptic Inhibition in Mouse Hippocampus" @default.
• W1977516874 cites W1516995431 @default.
• W1977516874 cites W1533152672 @default.
• W1977516874 cites W1973967768 @default.
• W1977516874 cites W1975888261 @default.
• W1977516874 cites W1976437022 @default.
• W1977516874 cites W1978342290 @default.
• W1977516874 cites W1979560116 @default.
• W1977516874 cites W1981732185 @default.
• W1977516874 cites W1985024007 @default.
• W1977516874 cites W1985220401 @default.
• W1977516874 cites W1985881933 @default.
• W1977516874 cites W1998240840 @default.
• W1977516874 cites W1999610563 @default.
• W1977516874 cites W2001619275 @default.
• W1977516874 cites W2004000308 @default.
• W1977516874 cites W2004937932 @default.
• W1977516874 cites W2009074192 @default.
• W1977516874 cites W2009667219 @default.
• W1977516874 cites W2010331856 @default.
• W1977516874 cites W2014438459 @default.
• W1977516874 cites W2017160535 @default.
• W1977516874 cites W2017195170 @default.
• W1977516874 cites W2024561575 @default.
• W1977516874 cites W2027782326 @default.
• W1977516874 cites W2031872972 @default.
• W1977516874 cites W2036337401 @default.
• W1977516874 cites W2037184237 @default.
• W1977516874 cites W2039369655 @default.
• W1977516874 cites W2039738625 @default.
• W1977516874 cites W2042887680 @default.
• W1977516874 cites W2043385322 @default.
• W1977516874 cites W2050658671 @default.
• W1977516874 cites W2050947120 @default.
• W1977516874 cites W2053290774 @default.
• W1977516874 cites W2056042967 @default.
• W1977516874 cites W2057106376 @default.
• W1977516874 cites W2059864318 @default.
• W1977516874 cites W2061366613 @default.
• W1977516874 cites W2062186332 @default.
• W1977516874 cites W2069498644 @default.
• W1977516874 cites W2074990246 @default.
• W1977516874 cites W2083547018 @default.
• W1977516874 cites W2083623577 @default.
• W1977516874 cites W2092102996 @default.
• W1977516874 cites W2097750478 @default.
• W1977516874 cites W2103860306 @default.
• W1977516874 cites W2106001183 @default.
• W1977516874 cites W2121237571 @default.
• W1977516874 cites W2124763074 @default.
• W1977516874 cites W2127725235 @default.
• W1977516874 cites W2130177841 @default.
• W1977516874 cites W2136115516 @default.
• W1977516874 cites W2138788537 @default.
• W1977516874 cites W2143086898 @default.
• W1977516874 cites W2143252669 @default.
• W1977516874 cites W2148169002 @default.
• W1977516874 cites W2152913045 @default.
• W1977516874 cites W2157852024 @default.
• W1977516874 cites W2165223719 @default.
• W1977516874 cites W2168245434 @default.
• W1977516874 cites W2171788395 @default.
• W1977516874 cites W2172091985 @default.
• W1977516874 cites W2203342607 @default.
• W1977516874 cites W2294136588 @default.
• W1977516874 cites W2299687596 @default.
• W1977516874 cites W4293254491 @default.
• W1977516874 cites W4296759754 @default.
• W1977516874 doi "https://doi.org/10.1152/jn.91203.2008" @default.
• W1977516874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2666407" @default.
• W1977516874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19073796" @default.
• W1977516874 hasPublicationYear "2009" @default.
• W1977516874 type Work @default.
• W1977516874 sameAs 1977516874 @default.
• W1977516874 citedByCount "91" @default.
• W1977516874 countsByYear W19775168742012 @default.
• W1977516874 countsByYear W19775168742013 @default.
• W1977516874 countsByYear W19775168742014 @default.
• W1977516874 countsByYear W19775168742015 @default.
• W1977516874 countsByYear W19775168742016 @default.
• W1977516874 countsByYear W19775168742017 @default.
• W1977516874 countsByYear W19775168742018 @default.
• W1977516874 countsByYear W19775168742019 @default.
• W1977516874 countsByYear W19775168742020 @default.
• W1977516874 countsByYear W19775168742021 @default.
• W1977516874 countsByYear W19775168742022 @default.
• W1977516874 countsByYear W19775168742023 @default.
• W1977516874 crossrefType "journal-article" @default.
• W1977516874 hasAuthorship W1977516874A5028902971 @default.
• W1977516874 hasAuthorship W1977516874A5036255755 @default.

• next