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• W1977520170 abstract "Scurry J, Vanin K, Ostor A. Comparison of histologicalfeatures of vulvar lichen sclerosis with and without adjacent squamous cellcarcinoma. Int J Gynecol Cancer 1997; 7: 392–399.To compare the histological features of vulvar lichen sclerosis with andwithout adjacent squamous cell carcinoma, sections of 132 consecutive cases ofvulvar squamous cellcarcinoma were examined to determine the characteristics of the epidermisadjacent to the carcinoma. Where lichen sclerosis was observed, its featureswere compared to those ofvulvar lichen sclerosis from 86 women without associated carcinoma. Lichensclerosis was seen in adjacent skin of 63 of 132 (48%) women with vulvarsquamous cell carcinoma. In61 of these 63, the epidermis was also significantly thickened. The changescausing the thickened epidermis could not be distinguished from superimposedlichen simplex chronicus in21 women. In the other 40, the main, but not the only, distinguishing featurewas differentiated vulvar intraepithelial neoplasia (basal atypia), which wasseen in 33. Otherdifferences were alterations in the ratios of hyperkeratosis, granulosis,acanthosis, and irregular prolongation of rete ridges. In lichen sclerosiswithout cancer, 73 women hadassociated epidermal thickening and in 69 of these the changes could not bedistinguished from superimposed lichen simplex chronicus; the other 4 showeddifferentiated andundifferentiated vulvar intraepithelial neoplasia in two women each. Weconclude that epidermal thickening is common in vulvar lichen sclerosis,whether occurring alone or inassociation with squamous cell carcinoma. Superimposed lichen simplex chronicuscannot fully explain the histological features of the epidermal thickening inlichen sclerosis inthe majority of women with carcinoma, but can do so in the majority of womenwithout carcinoma. In individual cases, however, there are no definitehistological criteria to distinguish hyperplasia from superimposed lichensimplex chronicus." @default.
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• W1977520170 date "1997-09-01" @default.
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• W1977520170 title "Comparison of histological features of vulvar lichen sclerosis with and withoutadjacent squamous cell carcinoma" @default.
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• W1977520170 doi "https://doi.org/10.1046/j.1525-1438.1997.00045.x" @default.
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