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• W1977521210 abstract "No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Dec 1999CHROMOSOME 9 MONOSOMY BY FLUORESCENCE IN SITU HYBRIDIZATION OF BLADDER IRRIGATION SPECIMENS IS PREDICTIVE OF TUMOR RECURRENCE ICHABOD JUNG, JAY E. REEDER, CHRISTOPHER COX, JOSEPHINE F.M. SIDDIQUI, MARY J. O’CONNELL, LORETTA COLLINS, ZHIHONG YANG, EDWARD M. MESSING, and LEON L. WHEELESS ICHABOD JUNGICHABOD JUNG More articles by this author , JAY E. REEDERJAY E. REEDER More articles by this author , CHRISTOPHER COXCHRISTOPHER COX More articles by this author , JOSEPHINE F.M. SIDDIQUIJOSEPHINE F.M. SIDDIQUI More articles by this author , MARY J. O’CONNELLMARY J. O’CONNELL More articles by this author , LORETTA COLLINSLORETTA COLLINS More articles by this author , ZHIHONG YANGZHIHONG YANG More articles by this author , EDWARD M. MESSINGEDWARD M. MESSING More articles by this author , and LEON L. WHEELESSLEON L. WHEELESS More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)68064-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Bladder irrigation specimens are effective for sampling the urothelium for detection of recurrent bladder cancer. These specimens can be evaluated by cytology or quantitative techniques. Proliferation and ploidy changes are readily detected using deoxyribonucleic acid (DNA) cytometry. Tumor associated chromosomal aberrations can be assayed using fluorescence in situ hybridization (FISH). The prognostic values of DNA cytometry, and chromosome 9 and 9p21 FISH on exfoliated cells from bladder irrigation specimens from 61 bladder cancer patients were evaluated. Materials and Methods: A total of 61 consecutive bladder irrigation specimens were obtained during cystoscopy. DNA cytometry was performed by image analysis. FISH was performed using a centromeric chromosome 9 probe and a cosmid contig (COSp16) probe to the CDKN2A/p16 tumor suppressor region of 9p21. Proportional hazards regression analysis was performed with statistical software to test the predictor variables of initial patient status (presence of tumor), COSp16 fraction (the proportion of COSp16 signals relative to centromeric probe signals), monosomic and hyperdisomic fractions of the chromosome 9 probe, and hyperdiploid fraction from DNA cytometry. Median time to recurrence was calculated using statistical software survival analysis. Results: Initial patient status and monosomy of chromosome 9 were predictive of bladder cancer recurrence (p <0.0001 and p = 0.0073, respectively). The 11 patients with chromosome 9 monosomy fractions greater than 15% and a visible tumor had a median time to recurrence of 105 days. In contrast, only 8 of the 25 patients with chromosome 9 monosomy fractions less than 15% and no visible tumor had recurrence within 560 days. Median time to recurrence was 185 days for 6 patients with chromosome 9 monosomy fractions greater than 15% and no visible tumor, and225 for 19 with chromosome 9 monosomy fractions less than 15% and a visible tumor. Hyperdiploid fraction was suggestive but not predictive of bladder cancer recurrence (p = 0.078). COSp16 and hyperdisomic fractions were not predictive of bladder tumor recurrence (p = 0.11 and p = 0.30, respectively). Conclusions: Chromosome 9 monosomy by FISH was predictive of bladder tumor recurrence. Furthermore, our findings support the hypothesis that losses of tumor suppressor genes on chromosome 9 are critical, perhaps initiating genetic events in bladder cancer. References 1 : Bladder and kidney cancers. Cancer Surv.1994; 19–20: 343. 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Google Scholar 10 : Preliminary mapping of the deleted region of chromosome 9 in bladder cancer. Cancer Res.1993; 53: 1230. Google Scholar 11 : Structure and methylation based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32–q33. Genomics1998; 48: 277. Google Scholar 12 : Definition of two regions of deletion on chromosome 9 in carcinoma of the bladder. Oncogene1994; 9: 2083. Google Scholar 13 : A cell cycle regulator potentially involved in genesis of many tumour types. Science1994; 264: 436. Google Scholar 14 : A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature1993; 366: 704. Google Scholar 15 : Bladder irrigation specimens assayed by fluorescence in situ hybridization to interphase nuclei. Cytometry1994; 17: 319. Google Scholar 16 : DNA cytometry and chromosome 9 aberrations by fluorescence in situ hybridization of irrigation specimens from bladder cancer patients. Urology1998; 51: 58. Google Scholar 17 : Loss of the CDKN2A/p16 locus detected in bladder irrigation specimens by fluorescence in situ hybridization. J. Urol.1997; 158: 1717. Link, Google Scholar 18 : Detection of CDKN2 deletions in tumor cell lines and primary glioma by interphase fluorescence in situ hybridization. Cancer Res.1995; 55: 984. Google Scholar 19 : Deoxyribonucleic acid ploidy enhances the cytological prediction of recurrent transitional cell carcinoma of the bladder. J. Urol.1997; 158: 806. Link, Google Scholar From the Departments of Urology, Pathology and Laboratory Medicine, and Biostatistics, University of Rochester, Rochester, New York© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBORHAN A, REEDER J, O’CONNELL M, WRIGHT K, WHEELESS L, di SANT’AGNESE P, McNALLY M and MESSING E (2018) Grade Progression and Regression in Recurrent Urothelial CancerJournal of Urology, VOL. 169, NO. 6, (2106-2109), Online publication date: 1-Jun-2003.WRIGHT K, MESSING E and REEDER J (2018) Increased Expression of the Acid Sphingomyelinase-Like Protein ASML3a in Bladder TumorsJournal of Urology, VOL. 168, NO. 6, (2645-2649), Online publication date: 1-Dec-2002.SHIGYO M, SUGANO K, TOBISU K, TSUKAMOTO T, SEKIYA T and KAKIZOE T (2018) MOLECULAR FOLLOWUP OF NEWLY DIAGNOSED BLADDER CANCER USING URINE SAMPLESJournal of Urology, VOL. 166, NO. 4, (1280-1285), Online publication date: 1-Oct-2001.SOURVINOS G, KAZANIS I, DELAKAS D, CRANIDIS A and SPANDIDOS D (2018) GENETIC DETECTION OF BLADDER CANCER BY MICROSATELLITE ANALYSIS OF p16, RB1 AND p53 TUMOR SUPPRESSOR GENESJournal of Urology, VOL. 165, NO. 1, (249-252), Online publication date: 1-Jan-2001. Volume 162Issue 6December 1999Page: 1900-1903 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.Keywordsfluorescencegenetic markerschromosomes, humanin situ hybridizationpair 9DNAbladderMetricsAuthor Information ICHABOD JUNG More articles by this author JAY E. REEDER More articles by this author CHRISTOPHER COX More articles by this author JOSEPHINE F.M. SIDDIQUI More articles by this author MARY J. O’CONNELL More articles by this author LORETTA COLLINS More articles by this author ZHIHONG YANG More articles by this author EDWARD M. MESSING More articles by this author LEON L. WHEELESS More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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