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- W1977533863 abstract "In comparisons of human burn conditions and mouse models of infection, we found that 1,608 genes, roughly 12% of the genes that changed in humans, changed in the same direction in mice, as indicated by Warren et al. (1). However, we argue that this fact does not indicate that mice are a poor animal model for the following reasons. First, at present, we do not understand 12% of the entire picture of a complex biological phenomenon such as inflammation, do we? If not, the shared changes of 1,608 genes may not be negligible and would be useful for understanding the mechanisms shared by humans and mice. Second, these genes involved 185 commonly and significantly changed molecular pathways/biogroups (dataset S1 in ref. 2), which could serve as potential targets for preclinical studies. Third, the statistical significance represented by the overlap P value estimated using NextBio characterizes not only the direction of the changes but also the extent (ranking) of the fold-changes (FCs). The P value (3.4 × 10−35) indicates an extraordinarily significant overlap, which motivated the use of the word “greatly” in the title of our paper. Furthermore, the similarity of gene expression patterns between human and mice was possibly underestimated. As Shay et al. (3) and we (2) point out, the datasets compared in Seok et al. have not been optimized for comparisons regarding matching of time courses/frames between human and mouse datasets, treatment effects, heterogeneity in human datasets, etc. As suggested by Shay et al., with more optimized datasets, the extent of similarity between human diseases and mouse models would become even stronger." @default.
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- W1977533863 date "2014-12-24" @default.
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- W1977533863 title "Reply to Warren et al. and Shay et al.: Commonalities across species do exist and are potentially important" @default.
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- W1977533863 doi "https://doi.org/10.1073/pnas.1417369111" @default.
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