FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977541353> ?p ?o ?g. }

• W1977541353 endingPage "396" @default.
• W1977541353 startingPage "387" @default.
• W1977541353 abstract "Cystic fibrosis transmembrane conductance regulator gene (CFTR) expression in human airway epithelial cells involves the recruitment of distal cis-regulatory elements, which are associated with airway-selective DNase hypersensitive sites at -44 kb and -35 kb from the gene. The -35-kb site encompasses an enhancer that is regulated by the immune mediators interferon regulatory factor 1 and 2 and by nuclear factor Y. Here we investigate the -44-kb element, which also has enhancer activity in vitro in airway epithelial cells but is inactive in intestinal epithelial cells. This site contains an antioxidant response element (ARE) that plays a critical role in its function in airway cell lines and primary human bronchial epithelial cells. The natural antioxidant sulforaphane (SFN) induces nuclear translocation of nuclear factor, erythroid 2-like 2 (Nrf2), a transcription factor that regulates genes with AREs in their promoters, many of which are involved in response to injury. Under normal conditions, the -44-kb ARE is occupied by the repressor BTB and CNC homology 1, basic leucine zipper transcription factor (Bach1), and v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MafK) heterodimers. After 2 hours of SFN treatment, Nrf2 displaces these repressive factors and activates CFTR expression. Site-directed mutagenesis shows that both the ARE and an adjacent NF-κB binding site are required for activation of the -44-kb element in airway epithelial cells. Moreover, this element is functionally linked to the -35-kb enhancer in modulating CFTR expression in response to environmental stresses in the airway." @default.
• W1977541353 created "2016-06-24" @default.
• W1977541353 creator A5003428139 @default.
• W1977541353 creator A5058375111 @default.
• W1977541353 creator A5085606046 @default.
• W1977541353 date "2015-03-01" @default.
• W1977541353 modified "2023-10-01" @default.
• W1977541353 title "Oxidative Stress Regulates <i>CFTR</i> Gene Expression in Human Airway Epithelial Cells through a Distal Antioxidant Response Element" @default.
• W1977541353 cites W1550521303 @default.
• W1977541353 cites W1574938804 @default.
• W1977541353 cites W1597544092 @default.
• W1977541353 cites W1949252567 @default.
• W1977541353 cites W1963590211 @default.
• W1977541353 cites W1978094617 @default.
• W1977541353 cites W1986099314 @default.
• W1977541353 cites W2003011230 @default.
• W1977541353 cites W2005644246 @default.
• W1977541353 cites W2015659378 @default.
• W1977541353 cites W2018219462 @default.
• W1977541353 cites W2025222765 @default.
• W1977541353 cites W2028130907 @default.
• W1977541353 cites W2030081449 @default.
• W1977541353 cites W2037983934 @default.
• W1977541353 cites W2042439512 @default.
• W1977541353 cites W2064113924 @default.
• W1977541353 cites W2064879068 @default.
• W1977541353 cites W2065661936 @default.
• W1977541353 cites W2070840393 @default.
• W1977541353 cites W2071677331 @default.
• W1977541353 cites W2077170717 @default.
• W1977541353 cites W2077447884 @default.
• W1977541353 cites W2079231943 @default.
• W1977541353 cites W2084519397 @default.
• W1977541353 cites W2087765393 @default.
• W1977541353 cites W2090554418 @default.
• W1977541353 cites W2093009907 @default.
• W1977541353 cites W2093507774 @default.
• W1977541353 cites W2096000363 @default.
• W1977541353 cites W2099875487 @default.
• W1977541353 cites W2100186169 @default.
• W1977541353 cites W2106237569 @default.
• W1977541353 cites W2106931266 @default.
• W1977541353 cites W2115272837 @default.
• W1977541353 cites W2118608526 @default.
• W1977541353 cites W2140422307 @default.
• W1977541353 cites W2140932443 @default.
• W1977541353 cites W2141008053 @default.
• W1977541353 cites W2146232554 @default.
• W1977541353 cites W2148970730 @default.
• W1977541353 cites W2152100400 @default.
• W1977541353 cites W2152706494 @default.
• W1977541353 cites W2154454863 @default.
• W1977541353 cites W2167852161 @default.
• W1977541353 cites W2255703111 @default.
• W1977541353 cites W4236860921 @default.
• W1977541353 doi "https://doi.org/10.1165/rcmb.2014-0263oc" @default.
• W1977541353 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4370264" @default.
• W1977541353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25259561" @default.
• W1977541353 hasPublicationYear "2015" @default.
• W1977541353 type Work @default.
• W1977541353 sameAs 1977541353 @default.
• W1977541353 citedByCount "40" @default.
• W1977541353 countsByYear W19775413532015 @default.
• W1977541353 countsByYear W19775413532016 @default.
• W1977541353 countsByYear W19775413532017 @default.
• W1977541353 countsByYear W19775413532018 @default.
• W1977541353 countsByYear W19775413532019 @default.
• W1977541353 countsByYear W19775413532020 @default.
• W1977541353 countsByYear W19775413532021 @default.
• W1977541353 countsByYear W19775413532022 @default.
• W1977541353 countsByYear W19775413532023 @default.
• W1977541353 crossrefType "journal-article" @default.
• W1977541353 hasAuthorship W1977541353A5003428139 @default.
• W1977541353 hasAuthorship W1977541353A5058375111 @default.
• W1977541353 hasAuthorship W1977541353A5085606046 @default.
• W1977541353 hasBestOaLocation W19775413532 @default.
• W1977541353 hasConcept C104317684 @default.
• W1977541353 hasConcept C111936080 @default.
• W1977541353 hasConcept C153911025 @default.
• W1977541353 hasConcept C185592680 @default.
• W1977541353 hasConcept C2778428886 @default.
• W1977541353 hasConcept C529295009 @default.
• W1977541353 hasConcept C54355233 @default.
• W1977541353 hasConcept C55493867 @default.
• W1977541353 hasConcept C86339819 @default.
• W1977541353 hasConcept C86803240 @default.
• W1977541353 hasConcept C87568996 @default.
• W1977541353 hasConcept C95444343 @default.
• W1977541353 hasConceptScore W1977541353C104317684 @default.
• W1977541353 hasConceptScore W1977541353C111936080 @default.
• W1977541353 hasConceptScore W1977541353C153911025 @default.
• W1977541353 hasConceptScore W1977541353C185592680 @default.
• W1977541353 hasConceptScore W1977541353C2778428886 @default.
• W1977541353 hasConceptScore W1977541353C529295009 @default.
• W1977541353 hasConceptScore W1977541353C54355233 @default.
• W1977541353 hasConceptScore W1977541353C55493867 @default.
• W1977541353 hasConceptScore W1977541353C86339819 @default.
• W1977541353 hasConceptScore W1977541353C86803240 @default.

• next