FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977565769> ?p ?o ?g. }

• W1977565769 endingPage "6534" @default.
• W1977565769 startingPage "6525" @default.
• W1977565769 abstract "Cellular metallothionein (MT) protects against Cd(2+) exposure through direct binding of the metal ion. The model reaction between rabbit liver Zn(7)-MT-2 with Cd(2+) was studied with stopped flow kinetics. Four kinetic steps were observable. Comparison of this reaction with an analog utilizing the MT Zn(4)-alpha domain revealed that only the fastest step involved the Zn(3)-beta domain. Each step of the Zn(4)-alpha domain reaction with Cd(2+) displayed hyperbolic dependence of the observed rate constant on Cd(2+) concentration, with the first step comprising 50% of the total reaction and each of the other two, 25%. The two constants extracted from each of these relationships were interpreted as the equilibrium constant for the initial binding of Cd(2+) to the Zn((4-n)),Cd(n)-thiolate cluster (n = 0-3) of the alpha domain and the first order rate constant for the exchange of Cd(2+) for Zn(2+) in the cluster. Activation enthalpies and entropies were determined for each constant. A suite of Zn((4-n)),Cd(n)-thiolate clusters (n = 0-3) was prepared by titration of the Zn(4)-alpha domain with (113)Cd(2+). The products were analyzed by one-dimensional (113)Cd(2+) NMR spectroscopy to define the distribution of (113)Cd(2+) among the four cluster binding sites. Each of these species was also reacted with Cd(2+). The properties of these reactions were similar to those extracted from the reaction of Cd(2+) with the overall domain. Thus, the kinetic results were linked to (113)Cd(2+) occupancy among the cluster metal binding sites. In turn, this linkage permitted the interpretation of the various constants determined for the reaction of Cd(2+) with the Zn(4)-alpha domain in relation to the alpha domain cluster structure." @default.
• W1977565769 created "2016-06-24" @default.
• W1977565769 creator A5008004363 @default.
• W1977565769 creator A5073602210 @default.
• W1977565769 creator A5087558821 @default.
• W1977565769 date "2010-06-18" @default.
• W1977565769 modified "2023-10-09" @default.
• W1977565769 title "Mechanism of Cadmium Ion Substitution in Mammalian Zinc Metallothionein and Metallothionein α Domain: Kinetic and Structural Studies" @default.
• W1977565769 cites W1482087249 @default.
• W1977565769 cites W1507671215 @default.
• W1977565769 cites W1604713610 @default.
• W1977565769 cites W1607127186 @default.
• W1977565769 cites W1615397418 @default.
• W1977565769 cites W1988528676 @default.
• W1977565769 cites W1992086776 @default.
• W1977565769 cites W1992706834 @default.
• W1977565769 cites W2012190775 @default.
• W1977565769 cites W2012985199 @default.
• W1977565769 cites W2032957963 @default.
• W1977565769 cites W2038844755 @default.
• W1977565769 cites W2050615089 @default.
• W1977565769 cites W2071026938 @default.
• W1977565769 cites W2073932673 @default.
• W1977565769 cites W2157810907 @default.
• W1977565769 cites W2394401629 @default.
• W1977565769 cites W2403293081 @default.
• W1977565769 cites W618157826 @default.
• W1977565769 doi "https://doi.org/10.1021/ic1003148" @default.
• W1977565769 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2935266" @default.
• W1977565769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20560649" @default.
• W1977565769 hasPublicationYear "2010" @default.
• W1977565769 type Work @default.
• W1977565769 sameAs 1977565769 @default.
• W1977565769 citedByCount "26" @default.
• W1977565769 countsByYear W19775657692012 @default.
• W1977565769 countsByYear W19775657692013 @default.
• W1977565769 countsByYear W19775657692014 @default.
• W1977565769 countsByYear W19775657692015 @default.
• W1977565769 countsByYear W19775657692016 @default.
• W1977565769 countsByYear W19775657692018 @default.
• W1977565769 countsByYear W19775657692019 @default.
• W1977565769 countsByYear W19775657692020 @default.
• W1977565769 countsByYear W19775657692021 @default.
• W1977565769 countsByYear W19775657692023 @default.
• W1977565769 crossrefType "journal-article" @default.
• W1977565769 hasAuthorship W1977565769A5008004363 @default.
• W1977565769 hasAuthorship W1977565769A5073602210 @default.
• W1977565769 hasAuthorship W1977565769A5087558821 @default.
• W1977565769 hasBestOaLocation W19775657692 @default.
• W1977565769 hasConcept C10710636 @default.
• W1977565769 hasConcept C121332964 @default.
• W1977565769 hasConcept C148898269 @default.
• W1977565769 hasConcept C178790620 @default.
• W1977565769 hasConcept C179104552 @default.
• W1977565769 hasConcept C184866935 @default.
• W1977565769 hasConcept C185592680 @default.
• W1977565769 hasConcept C199164860 @default.
• W1977565769 hasConcept C20719415 @default.
• W1977565769 hasConcept C535196362 @default.
• W1977565769 hasConcept C544153396 @default.
• W1977565769 hasConcept C544657597 @default.
• W1977565769 hasConcept C62520636 @default.
• W1977565769 hasConcept C71240020 @default.
• W1977565769 hasConcept C8010536 @default.
• W1977565769 hasConcept C93391505 @default.
• W1977565769 hasConceptScore W1977565769C10710636 @default.
• W1977565769 hasConceptScore W1977565769C121332964 @default.
• W1977565769 hasConceptScore W1977565769C148898269 @default.
• W1977565769 hasConceptScore W1977565769C178790620 @default.
• W1977565769 hasConceptScore W1977565769C179104552 @default.
• W1977565769 hasConceptScore W1977565769C184866935 @default.
• W1977565769 hasConceptScore W1977565769C185592680 @default.
• W1977565769 hasConceptScore W1977565769C199164860 @default.
• W1977565769 hasConceptScore W1977565769C20719415 @default.
• W1977565769 hasConceptScore W1977565769C535196362 @default.
• W1977565769 hasConceptScore W1977565769C544153396 @default.
• W1977565769 hasConceptScore W1977565769C544657597 @default.
• W1977565769 hasConceptScore W1977565769C62520636 @default.
• W1977565769 hasConceptScore W1977565769C71240020 @default.
• W1977565769 hasConceptScore W1977565769C8010536 @default.
• W1977565769 hasConceptScore W1977565769C93391505 @default.
• W1977565769 hasIssue "14" @default.
• W1977565769 hasLocation W19775657691 @default.
• W1977565769 hasLocation W19775657692 @default.
• W1977565769 hasLocation W19775657693 @default.
• W1977565769 hasLocation W19775657694 @default.
• W1977565769 hasOpenAccess W1977565769 @default.
• W1977565769 hasPrimaryLocation W19775657691 @default.
• W1977565769 hasRelatedWork W1976521028 @default.
• W1977565769 hasRelatedWork W2002364579 @default.
• W1977565769 hasRelatedWork W2029195799 @default.
• W1977565769 hasRelatedWork W2030345144 @default.
• W1977565769 hasRelatedWork W2038776007 @default.
• W1977565769 hasRelatedWork W2039094508 @default.
• W1977565769 hasRelatedWork W2069068045 @default.
• W1977565769 hasRelatedWork W2093731513 @default.
• W1977565769 hasRelatedWork W2160787121 @default.
• W1977565769 hasRelatedWork W2323715589 @default.

• next