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• W1977569713 abstract "Editorials1 September 1967Alcohol and the HeartCARL S. ALEXANDER, M.D.CARL S. ALEXANDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-670 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEarlier in this century much of clinical medicine in large urban hospitals was concerned with the diagnosis and management of syphilis and tuberculosis. Today, heart disease, cancer, and the complications of acute and chronic alcoholism attract our attention. The toxic effects of alcohol on the liver and brain are, of course, well-known, but less common and less well-known are the effects on skeletal and cardiac muscle.While the relationship of chronic alcoholism to heart disease was described by von Bollinger (1) in 1884, this was largely ignored while beriberi, originally described in the Orient (2), held the stage. It soon...References1. BOLLINGER OV: Ueber die Häufigkeit und Ursachen der idiopathischen Herzhypertrophie in München. Deutsch. Med. Wschr. 10: 180, 1884. CrossrefGoogle Scholar2. AALSMEERWENCKEBACH WCKF: Herz und Kreislauf bei der Beri-beri-Krankheit. Wien. Arch. Inn. Med. 16: 193, 1929. Google Scholar3. ALEXANDER CS: T-P phenomenon: an electrocardiographic clue to unsuspected alkalosis. Arch. Intern. Med. (Chicago) 116: 220, 1965. CrossrefMedlineGoogle Scholar4. MCDERMOTTDELANEYEAGANSULLIVAN PHRLJDJF: Myocardiosis and cardiac failure in men. JAMA 198: 253, 1966. CrossrefMedlineGoogle Scholar5. LANGERON L: [Alcoholic myocardia and alcoholic beri-beri. The two stages of alcoholic cardiac insufficiency. The notion of peripheral asystole.] (Fr.) J. Sci. Med. Lille 81: 3, 1963. MedlineGoogle Scholar6. BRIGDENROBINSON WJ: Alcoholic heart disease. Brit. Med. J. 2: 1283, 1964. CrossrefMedlineGoogle Scholar7. KULLERLILIENFELDFISHER LAR: Sudden and unexpected deaths in young adults. An epidemiological study. JAMA 198: 248, 1966. CrossrefMedlineGoogle Scholar8. HIRSTHADLEYGORE AEGGI: The effect of chronic alcoholism and cirrhosis of the liver on atherosclerosis. Amer. J. Med. Sci. 249: 143, 1965. CrossrefMedlineGoogle Scholar9. PINTARWOLANSKYJGUBBAY KBMER: Alcoholic cardiomyopathy. Canad. Med. Ass. J. 93: 103, 1965. MedlineGoogle Scholar10. BENCHIMOLSCHLESINGER ABP: Beriberi heart disease. Amer. Heart J. 46: 245, 1953. CrossrefMedlineGoogle Scholar11. HIBBSFERRANSBLACKWALSHBURCH RGVJWCJJGE: Alcoholic cardiomyopathy. An electron microscopic study. Amer. Heart J. 69: 766, 1965. CrossrefMedlineGoogle Scholar12. ALEXANDER CS: Idiopathic heart disease. II. Electron microscopic examination of myocardial biopsy specimens in alcoholic heart disease. Amer. J. Med. 41: 229, 1966. CrossrefMedlineGoogle Scholar13. ALEXANDER CS: Electron microscopic observations in alcoholic heart disease. Brit. Heart J. 29: 200, 1967. CrossrefMedlineGoogle Scholar14. 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LASKERSHERRODKILLAM NTRKF: Alcohol on the coronary circulation of the dog. J. Pharmacol. Exp. Ther. 113: 415, 1955. Google Scholar21. UNALWEBBCOOK MWRWA: Alcohol and myocardial metabolism. Surg. Forum 16: 61, 1965. MedlineGoogle Scholar22. WEBBDEGERLICOOKUNAL WRIUWAMO: Alcohol, digitalis and cortisol, and myocardial capacity in dogs. Ann. Surg. 163: 811, 1966. CrossrefMedlineGoogle Scholar23. LINDENEGMELLEMGAARDFABRICIUSLUNDQUIST OKJF: Myocardial utilization of acetate, lactate, and free fatty acids after ingestion of ethanol. Clin. Sci. 27: 427, 1964. MedlineGoogle Scholar24. BING RJ: Cardiac metabolism. Physiol. Rev. 45: 171, 1965. CrossrefMedlineGoogle Scholar25. KITTLEAOKIBROWN CFHEB: The role of pH and CO2 in the distribution of blood flow. Surgery 57: 139, 1965. MedlineGoogle Scholar26. WENDTAJLUNIBRUCEPRASADBING VERTAASRJ: Acute effects of alcohol on the human myocardium. Amer. J. Cardiol. 17: 804, 1966. CrossrefGoogle Scholar27. HARTROFTPORTA WSEA: Experimental alcoholic hepatic injury. Nutr. Rev. 24: 97, 1966. CrossrefMedlineGoogle Scholar28. KLINKERFUSSBLEISCHDIOSOPERKOFF GVMMGT: A spectrum of myopathy associated with alcoholism. II. Light and electron microscopic observations. Ann. Intern. Med. 67: 493, 1967. LinkGoogle Scholar29. SUSINHERDSON MPB: Fine structural changes induced in rat myocardium by sodium L-thyroxine and by magnesium deficiency. Arch. Path. (Chicago) 83: 86, 167. Google Scholar30. WENERPINTARSIMONMOTOLAFRIEDMANMAYMANSCHUCHER JKMARRAR: The effects of prolonged hypomagnesemia on the cardiovascular system in young dogs. Amer. Heart J. 67: 221, 1964. CrossrefMedlineGoogle Scholar31. WENDTWOLFAJLUNIOBERLEASPRASAD VEPLRDAS: The role of zinc in myocardial metabolism, in Zinc Metabolism, edited by PRASAD, A. S. Charles C Thomas, Publisher, Springfield, Ill., 1966, pp. 395-410. Google Scholar32. CHERRICKLEEVY GRCM: The effect of ethanol metabolism on levels of oxidized and reduced nicotinamide-adenine dinucleotide in liver, kidney, and heart. Biochim. Biophys. Acta 10: 729, 1965. Google Scholar33. DAVISBROWNHOFFCASHAW VEHJAJL: The alteration of serotonin metabolism to 5-hydroxytryptophol by ethanol ingestion in man. J. Lab. Clin. Med. 69: 132, 1967. MedlineGoogle Scholar34. DAVISBROWNHOFFCASHAW VEHJAJL: Ethanol-induced alterations of norepinephrine metabolism in man. Ibid., p. 787. Google Scholar35. MCARTHUR WJ: Coronary flow response to hypocapnia induced by hyperventilation. Aerospace Med. 36: 5, 1965. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Minneapolis Veterans Hospital and University of Minnesota Minneapolis, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDictionary of Inorganic CompoundsDer alkoholkranke Patient auf der IntensivstationSome recent advances in cardiac pathologyEffect of ethanol on cardiac function in rats genetically selected for their ethanol preferenceEffect of ethanol infusion on the ultrastructure of human myocardiumHEART PATHOLOGY IN CHRONIC ALCOHOLISMAlcohol and the BloodThe influence of quantity of beer consumed on the myocardium of miceCobalt-beer cardiomyopathyThe effect of ingestion of ethyl alcohol, wine and beer on the myocardium of miceThe Role of Acetaldehyde in the Actions of EthanolAlcoholic Muscle Disease 1 September 1967Volume 67, Issue 3_Part_1Page: 670-674KeywordsAlcoholismAlcoholsBeriberiBrainCardiac musclesCardiovascular therapyHeartHospital medicineLiverSyphilis Issue Published: 1 September 1967 PDF DownloadLoading ..." @default.
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