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- W1977576572 abstract "The product inhibition of aminopyrine (AM) N-demethylation by 4-monomethylaminoantipyrine (MAA) was examined in vitro in preparations of isolated rat hepatocytes using gas chromatograph-mass spectrometer (GC-MS). the kinetic study of AM N-demethylation, which was determined by MAA formation, was studied at concentrations from 0.2 to 4.0 mM with or without various concentrations of D3-MAA.D3-MAA inhibited AM N-demethylation non-competitively at concentrations of 0.2 to 1.0 mM of AM (ki=1.81 mM), though it did competitively at concentations of 1.0 to 4.0 mM of AM (Ki=0.81 mM). From the present observation, it was suggested that the inhibition type of AM N-demethylation by D3-MAA was dependent on the substrate (AM) concentration." @default.
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- W1977576572 title "Product inhibition of aminopyrine N-demethylation in isolated hepatocytes." @default.
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- W1977576572 doi "https://doi.org/10.1248/bpb1978.8.193" @default.
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