FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977580387> ?p ?o ?g. }

• W1977580387 endingPage "e47522" @default.
• W1977580387 startingPage "e47522" @default.
• W1977580387 abstract "Toll-like receptors (TLRs) play essential roles in innate immunity and increasing evidence indicates that these receptors are expressed in neurons, astrocytes and microglia in the brain where they mediate responses to infection, stress and injury. Very little is known about the roles of TLRs in cognition. To test the hypothesis that TLR4 has a role in hippocampus-dependent spatial learning and memory, we used mice deficient for TLR4 and mice receiving chronic TLR4 antagonist infusion to the lateral ventricles in the brain. We found that developmental TLR4 deficiency enhances spatial reference memory acquisition and memory retention, impairs contextual fear-learning and enhances motor functions, traits that were correlated with CREB up-regulation in the hippocampus. TLR4 antagonist infusion into the cerebral ventricles of adult mice did not affect cognitive behavior, but instead affected anxiety responses. Our findings indicate a developmental role for TLR4 in shaping spatial reference memory, and fear learning and memory. Moreover, we show that central TLR4 inhibition using a TLR4 antagonist has no discernible physiological role in regulating spatial and contextual hippocampus-dependent cognitive behavior." @default.
• W1977580387 created "2016-06-24" @default.
• W1977580387 creator A5000871493 @default.
• W1977580387 creator A5001397329 @default.
• W1977580387 creator A5017462929 @default.
• W1977580387 creator A5023604377 @default.
• W1977580387 creator A5037892265 @default.
• W1977580387 creator A5048092197 @default.
• W1977580387 creator A5049406054 @default.
• W1977580387 creator A5064651500 @default.
• W1977580387 creator A5073647642 @default.
• W1977580387 creator A5079615522 @default.
• W1977580387 creator A5079636891 @default.
• W1977580387 creator A5083040475 @default.
• W1977580387 date "2012-10-11" @default.
• W1977580387 modified "2023-10-02" @default.
• W1977580387 title "Evidence for a Developmental Role for TLR4 in Learning and Memory" @default.
• W1977580387 cites W1522048223 @default.
• W1977580387 cites W168035116 @default.
• W1977580387 cites W1976010325 @default.
• W1977580387 cites W1979216870 @default.
• W1977580387 cites W1988178045 @default.
• W1977580387 cites W2008326600 @default.
• W1977580387 cites W2011355679 @default.
• W1977580387 cites W2017610018 @default.
• W1977580387 cites W2030877933 @default.
• W1977580387 cites W2041895866 @default.
• W1977580387 cites W2048721710 @default.
• W1977580387 cites W2053544091 @default.
• W1977580387 cites W2054538838 @default.
• W1977580387 cites W2082087376 @default.
• W1977580387 cites W2083579715 @default.
• W1977580387 cites W2094632811 @default.
• W1977580387 cites W2106949373 @default.
• W1977580387 cites W2127550021 @default.
• W1977580387 cites W2141391979 @default.
• W1977580387 cites W2144679012 @default.
• W1977580387 cites W2156414024 @default.
• W1977580387 cites W2163543774 @default.
• W1977580387 cites W92044437 @default.
• W1977580387 doi "https://doi.org/10.1371/journal.pone.0047522" @default.
• W1977580387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3469493" @default.
• W1977580387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23071817" @default.
• W1977580387 hasPublicationYear "2012" @default.
• W1977580387 type Work @default.
• W1977580387 sameAs 1977580387 @default.
• W1977580387 citedByCount "105" @default.
• W1977580387 countsByYear W19775803872013 @default.
• W1977580387 countsByYear W19775803872014 @default.
• W1977580387 countsByYear W19775803872015 @default.
• W1977580387 countsByYear W19775803872016 @default.
• W1977580387 countsByYear W19775803872017 @default.
• W1977580387 countsByYear W19775803872018 @default.
• W1977580387 countsByYear W19775803872019 @default.
• W1977580387 countsByYear W19775803872020 @default.
• W1977580387 countsByYear W19775803872021 @default.
• W1977580387 countsByYear W19775803872022 @default.
• W1977580387 countsByYear W19775803872023 @default.
• W1977580387 crossrefType "journal-article" @default.
• W1977580387 hasAuthorship W1977580387A5000871493 @default.
• W1977580387 hasAuthorship W1977580387A5001397329 @default.
• W1977580387 hasAuthorship W1977580387A5017462929 @default.
• W1977580387 hasAuthorship W1977580387A5023604377 @default.
• W1977580387 hasAuthorship W1977580387A5037892265 @default.
• W1977580387 hasAuthorship W1977580387A5048092197 @default.
• W1977580387 hasAuthorship W1977580387A5049406054 @default.
• W1977580387 hasAuthorship W1977580387A5064651500 @default.
• W1977580387 hasAuthorship W1977580387A5073647642 @default.
• W1977580387 hasAuthorship W1977580387A5079615522 @default.
• W1977580387 hasAuthorship W1977580387A5079636891 @default.
• W1977580387 hasAuthorship W1977580387A5083040475 @default.
• W1977580387 hasBestOaLocation W19775803871 @default.
• W1977580387 hasConcept C126322002 @default.
• W1977580387 hasConcept C15744967 @default.
• W1977580387 hasConcept C169760540 @default.
• W1977580387 hasConcept C169900460 @default.
• W1977580387 hasConcept C170493617 @default.
• W1977580387 hasConcept C203014093 @default.
• W1977580387 hasConcept C21963081 @default.
• W1977580387 hasConcept C2776070231 @default.
• W1977580387 hasConcept C2776914184 @default.
• W1977580387 hasConcept C2779830541 @default.
• W1977580387 hasConcept C2780744974 @default.
• W1977580387 hasConcept C2781161787 @default.
• W1977580387 hasConcept C43729271 @default.
• W1977580387 hasConcept C44752575 @default.
• W1977580387 hasConcept C71924100 @default.
• W1977580387 hasConcept C86803240 @default.
• W1977580387 hasConceptScore W1977580387C126322002 @default.
• W1977580387 hasConceptScore W1977580387C15744967 @default.
• W1977580387 hasConceptScore W1977580387C169760540 @default.
• W1977580387 hasConceptScore W1977580387C169900460 @default.
• W1977580387 hasConceptScore W1977580387C170493617 @default.
• W1977580387 hasConceptScore W1977580387C203014093 @default.
• W1977580387 hasConceptScore W1977580387C21963081 @default.
• W1977580387 hasConceptScore W1977580387C2776070231 @default.
• W1977580387 hasConceptScore W1977580387C2776914184 @default.
• W1977580387 hasConceptScore W1977580387C2779830541 @default.

• next