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- W1977583742 abstract "The effect of baclofen on static γ-activity enhanced by pinna pinching was compared with some of centrally acting muscle relaxants (chlorpromazine, mephenesin and diazepam) in the anesthetized rat. Baclofen (0.5-2 mg/kg, i.v.) showed only a little effect on the static γ-activity. At a higher dose of 5 mg/kg, the drug showed a marked depressant effect on the static γ-activity, although this dose was much higher than that required to depress spinal reflex activity. On the other hand, chlorpromazine, mephenesin and diazepam depressed the static γ-activity at lower doses than those required to depress spinal reflex activity. From these results, it is concluded that the depressant action of baclofen on the static γ-activity has only a little contribution to the muscle relaxant action and therapeutic effectiveness of the drug." @default.
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- W1977583742 date "1979-01-01" @default.
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- W1977583742 title "Effect of baclofen on the .GAMMA.-motor activity in the rat." @default.
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- W1977583742 doi "https://doi.org/10.1248/bpb1978.2.60" @default.
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