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• W1977583809 endingPage "406" @default.
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• W1977583809 abstract "Abstract Retinoic acid (RA) and 1,25-(OH)2-vitamin D3 (1,25-D3) induced U937 cell maturation into distinct monocytic phenotypes, as demonstrated by up-regulation of CD23 by RA and CD14 by 1,25-D3. Differentiation by RA but not by 1,25-D3 was associated with reduction of basal and complete suppression of interferon-γ (IFN-γ)–stimulated intercellular adhesion molecule 1 (ICAM-1) expression. Induction of cyclooxygenase activity by RA and attenuation of basal ICAM-1 expression exhibited similar kinetics. Treatment with indomethacin prevented and prostaglandin E2 (PGE2), dibutyryl-cAMP, or forskolin mimicked reduction of basal ICAM-1 expression by RA, indicating that this effect of RA is mediated by PGE2 synthesis and subsequent cAMP elevation. In contrast, suppression of IFN-γ-induced ICAM-1 expression by RA was only partly reversible by indomethacin, suggesting that inhibition of IFN-γ stimulation was not completely due to cyclooxygenase induction. RA did not always counteract IFN-γ, as it cooperated with IFN-γ in down-regulating very late activation antigen 4. Specific polymerase chain reaction and Northern blotting of ICAM-1 mRNA revealed that RA suppressed ICAM-1 induction by IFN-γ at the transcriptional level. RA also blocked ICAM-1 induction by IFN-γ in isolated human blood monocytes. In conclusion, inhibition of basal and stimulated ICAM-1 expression in monocytic cells may provide a mechanism for beneficial anti-inflammatory effects of retinoids. J. Leukoc. Biol. 57: 401–406; 1995." @default.
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• W1977583809 date "1995-03-01" @default.
• W1977583809 modified "2023-09-27" @default.
• W1977583809 title "Retinoic acid inhibits basal and interferon-γ-induced expression of intercellular adhesion molecule 1 in monocytic cells" @default.
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• W1977583809 doi "https://doi.org/10.1002/jlb.57.3.401" @default.
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