FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977587295> ?p ?o ?g. }

• W1977587295 endingPage "629" @default.
• W1977587295 startingPage "622" @default.
• W1977587295 abstract "Cobalt−alkyne complexes are drugs with remarkable cytotoxicity. From the complexes tested up to now we selected the aspirin derivative [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt (Co-ASS) as the lead compound. To get more insight into the mode of action, we systematically modified the alkyne ligand and determined the cytotoxic properties of the resulting cobalt complexes. Further investigations were performed on the drug lipophilicity, the cellular uptake into MCF-7 and MDA-MB 231 breast cancer cells, the DNA-binding efficacy, and the nuclear drug content. The ability to inhibit glutathione reductase and cyclooxygenase (COX) enzymes, the binding to the estrogen receptor, and the induction of apoptotic processes were examined for selected compounds. Interestingly, the most antitumor active compounds were potent COX inhibitors (COX-1 and COX-2). The presented results indicate that cobalt−alkyne complexes of the Co-ASS type, represent a new class of organometallic cytostatics with a mode of drug action in which COX inhibition probably plays a major role." @default.
• W1977587295 created "2016-06-24" @default.
• W1977587295 creator A5042277242 @default.
• W1977587295 creator A5052486824 @default.
• W1977587295 creator A5057876555 @default.
• W1977587295 creator A5068338253 @default.
• W1977587295 creator A5070842135 @default.
• W1977587295 creator A5077948100 @default.
• W1977587295 date "2004-12-30" @default.
• W1977587295 modified "2023-10-14" @default.
• W1977587295 title "Antitumor-Active Cobalt−Alkyne Complexes Derived from Acetylsalicylic Acid: Studies on the Mode of Drug Action" @default.
• W1977587295 cites W1271509714 @default.
• W1977587295 cites W1849061857 @default.
• W1977587295 cites W1965037168 @default.
• W1977587295 cites W1970052699 @default.
• W1977587295 cites W1972016476 @default.
• W1977587295 cites W1974726848 @default.
• W1977587295 cites W1982239348 @default.
• W1977587295 cites W2000724113 @default.
• W1977587295 cites W2008820074 @default.
• W1977587295 cites W2009132110 @default.
• W1977587295 cites W2022357672 @default.
• W1977587295 cites W2024001803 @default.
• W1977587295 cites W2028128713 @default.
• W1977587295 cites W2041778777 @default.
• W1977587295 cites W2044311286 @default.
• W1977587295 cites W2046097532 @default.
• W1977587295 cites W2052736304 @default.
• W1977587295 cites W2063828804 @default.
• W1977587295 cites W2076494430 @default.
• W1977587295 cites W2076590791 @default.
• W1977587295 cites W2081863781 @default.
• W1977587295 cites W2130460967 @default.
• W1977587295 cites W2133497268 @default.
• W1977587295 cites W2149083834 @default.
• W1977587295 cites W2159330401 @default.
• W1977587295 cites W4293247451 @default.
• W1977587295 doi "https://doi.org/10.1021/jm049326z" @default.
• W1977587295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15658875" @default.
• W1977587295 hasPublicationYear "2004" @default.
• W1977587295 type Work @default.
• W1977587295 sameAs 1977587295 @default.
• W1977587295 citedByCount "193" @default.
• W1977587295 countsByYear W19775872952012 @default.
• W1977587295 countsByYear W19775872952013 @default.
• W1977587295 countsByYear W19775872952014 @default.
• W1977587295 countsByYear W19775872952015 @default.
• W1977587295 countsByYear W19775872952016 @default.
• W1977587295 countsByYear W19775872952017 @default.
• W1977587295 countsByYear W19775872952018 @default.
• W1977587295 countsByYear W19775872952019 @default.
• W1977587295 countsByYear W19775872952020 @default.
• W1977587295 countsByYear W19775872952021 @default.
• W1977587295 countsByYear W19775872952022 @default.
• W1977587295 countsByYear W19775872952023 @default.
• W1977587295 crossrefType "journal-article" @default.
• W1977587295 hasAuthorship W1977587295A5042277242 @default.
• W1977587295 hasAuthorship W1977587295A5052486824 @default.
• W1977587295 hasAuthorship W1977587295A5057876555 @default.
• W1977587295 hasAuthorship W1977587295A5068338253 @default.
• W1977587295 hasAuthorship W1977587295A5070842135 @default.
• W1977587295 hasAuthorship W1977587295A5077948100 @default.
• W1977587295 hasConcept C109316439 @default.
• W1977587295 hasConcept C121587506 @default.
• W1977587295 hasConcept C121608353 @default.
• W1977587295 hasConcept C126322002 @default.
• W1977587295 hasConcept C161790260 @default.
• W1977587295 hasConcept C178790620 @default.
• W1977587295 hasConcept C181199279 @default.
• W1977587295 hasConcept C185592680 @default.
• W1977587295 hasConcept C201399114 @default.
• W1977587295 hasConcept C202751555 @default.
• W1977587295 hasConcept C21951064 @default.
• W1977587295 hasConcept C2776120743 @default.
• W1977587295 hasConcept C2779012754 @default.
• W1977587295 hasConcept C2780035454 @default.
• W1977587295 hasConcept C515602321 @default.
• W1977587295 hasConcept C530470458 @default.
• W1977587295 hasConcept C55493867 @default.
• W1977587295 hasConcept C71240020 @default.
• W1977587295 hasConcept C71924100 @default.
• W1977587295 hasConcept C84606932 @default.
• W1977587295 hasConcept C98274493 @default.
• W1977587295 hasConceptScore W1977587295C109316439 @default.
• W1977587295 hasConceptScore W1977587295C121587506 @default.
• W1977587295 hasConceptScore W1977587295C121608353 @default.
• W1977587295 hasConceptScore W1977587295C126322002 @default.
• W1977587295 hasConceptScore W1977587295C161790260 @default.
• W1977587295 hasConceptScore W1977587295C178790620 @default.
• W1977587295 hasConceptScore W1977587295C181199279 @default.
• W1977587295 hasConceptScore W1977587295C185592680 @default.
• W1977587295 hasConceptScore W1977587295C201399114 @default.
• W1977587295 hasConceptScore W1977587295C202751555 @default.
• W1977587295 hasConceptScore W1977587295C21951064 @default.
• W1977587295 hasConceptScore W1977587295C2776120743 @default.
• W1977587295 hasConceptScore W1977587295C2779012754 @default.
• W1977587295 hasConceptScore W1977587295C2780035454 @default.
• W1977587295 hasConceptScore W1977587295C515602321 @default.

• next