FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977589132> ?p ?o ?g. }

• W1977589132 endingPage "185" @default.
• W1977589132 startingPage "178" @default.
• W1977589132 abstract "New onset diabetes is a major complication after kidney transplantation. However, the incidence, risk factors and clinical relevance of post-transplant diabetes mellitus (PTDM) vary among reports from single-center observational studies and clinical trials. Using data from the United Renal Data System we identified 11 659 Medicare beneficiaries who received their first kidney transplant in 1996–2000. The cumulative incidence of PTDM was 9.1% (95% confidence interval = 8.6–9.7%), 16.0% (15.3–16.7%), and 24.0% (23.1–24.9%) at 3, 12, and 36 months post-transplant, respectively. Using Cox's proportional hazards analysis, risk factors for PTDM included age, African American race (relative risk = 1.68, range: 1.52–1.85, p < 0.0001), Hispanic ethnicity (1.35, range: 1.19–1.54, p < 0.0001), male donor (1.12, range: 1.03–1.21, p = 0.0090), increasing HLA mismatches, hepatitis C infection (1.33, range: 1.15–1.55, p < 0.0001), body mass index ≥30 kg/m2 (1.73, range: 1.57–1.90, p < 0.0001), and the use of tacrolimus as the initial maintenance immunosuppressive medication (1.53, range: 1.29–1.81, p < 0.0001). Factors that reduced the risk for PTDM included the use of mycophenolate mofetil, azathioprine, younger recipient age, glomerulonephritis as a cause of kidney failure, and a college education. As a time-dependent covariate in Cox analyses that also included multiple other risk factors, PTDM was associated with increased graft failure (1.63, 1.46–1.84, p < 0.0001), death-censored graft failure (1.46, 1.25–1.70, p < 0.0001), and mortality (1.87, 1.60–2.18, p < 0.0001). We conclude that high incidences of PTDM are associated with the type of initial maintenance immunosuppression, race, ethnicity, obesity and hepatitis C infection. It is a strong, independent predictor of graft failure and mortality. Efforts should be made to minimize the risk of this important complication. New onset diabetes is a major complication after kidney transplantation. However, the incidence, risk factors and clinical relevance of post-transplant diabetes mellitus (PTDM) vary among reports from single-center observational studies and clinical trials. Using data from the United Renal Data System we identified 11 659 Medicare beneficiaries who received their first kidney transplant in 1996–2000. The cumulative incidence of PTDM was 9.1% (95% confidence interval = 8.6–9.7%), 16.0% (15.3–16.7%), and 24.0% (23.1–24.9%) at 3, 12, and 36 months post-transplant, respectively. Using Cox's proportional hazards analysis, risk factors for PTDM included age, African American race (relative risk = 1.68, range: 1.52–1.85, p < 0.0001), Hispanic ethnicity (1.35, range: 1.19–1.54, p < 0.0001), male donor (1.12, range: 1.03–1.21, p = 0.0090), increasing HLA mismatches, hepatitis C infection (1.33, range: 1.15–1.55, p < 0.0001), body mass index ≥30 kg/m2 (1.73, range: 1.57–1.90, p < 0.0001), and the use of tacrolimus as the initial maintenance immunosuppressive medication (1.53, range: 1.29–1.81, p < 0.0001). Factors that reduced the risk for PTDM included the use of mycophenolate mofetil, azathioprine, younger recipient age, glomerulonephritis as a cause of kidney failure, and a college education. As a time-dependent covariate in Cox analyses that also included multiple other risk factors, PTDM was associated with increased graft failure (1.63, 1.46–1.84, p < 0.0001), death-censored graft failure (1.46, 1.25–1.70, p < 0.0001), and mortality (1.87, 1.60–2.18, p < 0.0001). We conclude that high incidences of PTDM are associated with the type of initial maintenance immunosuppression, race, ethnicity, obesity and hepatitis C infection. It is a strong, independent predictor of graft failure and mortality. Efforts should be made to minimize the risk of this important complication." @default.
• W1977589132 created "2016-06-24" @default.
• W1977589132 creator A5017256940 @default.
• W1977589132 creator A5021274317 @default.
• W1977589132 creator A5029712397 @default.
• W1977589132 creator A5087231272 @default.
• W1977589132 date "2003-02-01" @default.
• W1977589132 modified "2023-10-14" @default.
• W1977589132 title "Diabetes Mellitus after Kidney Transplantation in the United States" @default.
• W1977589132 cites W1977648113 @default.
• W1977589132 cites W1983779046 @default.
• W1977589132 cites W1985498707 @default.
• W1977589132 cites W1990675164 @default.
• W1977589132 cites W2011010559 @default.
• W1977589132 cites W2018953484 @default.
• W1977589132 cites W2027371366 @default.
• W1977589132 cites W2032753565 @default.
• W1977589132 cites W2033692936 @default.
• W1977589132 cites W2039764712 @default.
• W1977589132 cites W2044600432 @default.
• W1977589132 cites W2047022313 @default.
• W1977589132 cites W2050503581 @default.
• W1977589132 cites W2051932458 @default.
• W1977589132 cites W2059953949 @default.
• W1977589132 cites W2073233631 @default.
• W1977589132 cites W2076597593 @default.
• W1977589132 cites W2078718522 @default.
• W1977589132 cites W2084740518 @default.
• W1977589132 cites W2088756929 @default.
• W1977589132 cites W2092983614 @default.
• W1977589132 cites W2150121546 @default.
• W1977589132 cites W2154981317 @default.
• W1977589132 cites W2158798330 @default.
• W1977589132 cites W2158822657 @default.
• W1977589132 cites W2312949204 @default.
• W1977589132 cites W32301231 @default.
• W1977589132 doi "https://doi.org/10.1034/j.1600-6143.2003.00010.x" @default.
• W1977589132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12603213" @default.
• W1977589132 hasPublicationYear "2003" @default.
• W1977589132 type Work @default.
• W1977589132 sameAs 1977589132 @default.
• W1977589132 citedByCount "1163" @default.
• W1977589132 countsByYear W19775891322012 @default.
• W1977589132 countsByYear W19775891322013 @default.
• W1977589132 countsByYear W19775891322014 @default.
• W1977589132 countsByYear W19775891322015 @default.
• W1977589132 countsByYear W19775891322016 @default.
• W1977589132 countsByYear W19775891322017 @default.
• W1977589132 countsByYear W19775891322018 @default.
• W1977589132 countsByYear W19775891322019 @default.
• W1977589132 countsByYear W19775891322020 @default.
• W1977589132 countsByYear W19775891322021 @default.
• W1977589132 countsByYear W19775891322022 @default.
• W1977589132 countsByYear W19775891322023 @default.
• W1977589132 crossrefType "journal-article" @default.
• W1977589132 hasAuthorship W1977589132A5017256940 @default.
• W1977589132 hasAuthorship W1977589132A5021274317 @default.
• W1977589132 hasAuthorship W1977589132A5029712397 @default.
• W1977589132 hasAuthorship W1977589132A5087231272 @default.
• W1977589132 hasBestOaLocation W19775891321 @default.
• W1977589132 hasConcept C120665830 @default.
• W1977589132 hasConcept C121332964 @default.
• W1977589132 hasConcept C126322002 @default.
• W1977589132 hasConcept C134018914 @default.
• W1977589132 hasConcept C141071460 @default.
• W1977589132 hasConcept C207103383 @default.
• W1977589132 hasConcept C2776760755 @default.
• W1977589132 hasConcept C2779134260 @default.
• W1977589132 hasConcept C2780221984 @default.
• W1977589132 hasConcept C2780303639 @default.
• W1977589132 hasConcept C2909675724 @default.
• W1977589132 hasConcept C2911091166 @default.
• W1977589132 hasConcept C44249647 @default.
• W1977589132 hasConcept C50382708 @default.
• W1977589132 hasConcept C50440223 @default.
• W1977589132 hasConcept C555293320 @default.
• W1977589132 hasConcept C61511704 @default.
• W1977589132 hasConcept C71924100 @default.
• W1977589132 hasConcept C82789193 @default.
• W1977589132 hasConcept C88879693 @default.
• W1977589132 hasConcept C90924648 @default.
• W1977589132 hasConceptScore W1977589132C120665830 @default.
• W1977589132 hasConceptScore W1977589132C121332964 @default.
• W1977589132 hasConceptScore W1977589132C126322002 @default.
• W1977589132 hasConceptScore W1977589132C134018914 @default.
• W1977589132 hasConceptScore W1977589132C141071460 @default.
• W1977589132 hasConceptScore W1977589132C207103383 @default.
• W1977589132 hasConceptScore W1977589132C2776760755 @default.
• W1977589132 hasConceptScore W1977589132C2779134260 @default.
• W1977589132 hasConceptScore W1977589132C2780221984 @default.
• W1977589132 hasConceptScore W1977589132C2780303639 @default.
• W1977589132 hasConceptScore W1977589132C2909675724 @default.
• W1977589132 hasConceptScore W1977589132C2911091166 @default.
• W1977589132 hasConceptScore W1977589132C44249647 @default.
• W1977589132 hasConceptScore W1977589132C50382708 @default.
• W1977589132 hasConceptScore W1977589132C50440223 @default.
• W1977589132 hasConceptScore W1977589132C555293320 @default.
• W1977589132 hasConceptScore W1977589132C61511704 @default.

• next