FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977599327> ?p ?o ?g. }

• W1977599327 endingPage "551" @default.
• W1977599327 startingPage "545" @default.
• W1977599327 abstract "The actions of cholecystokinin octapeptide (CCK) on the membrane properties of mouse spinal neurons grown in monolayer culture were examined using intracellular recording techniques. In a subpopulation of cells, application of CCK (0.2–100 μM) by pressure ejection from micropipettes produced a small (∼2 mV) membrane depolarization that was accompanied by a decrease in membrane conductance (∼11 percent). These effects were associated with an enhanced tendency of the cells to generate action potentials when stimulated with intracellular depolarizing current. The unsulfated analog of CCK, which possesses weak biological activity in the gut, had little or no effect on cultured spinal neurons. A number of differences were noted between the responses to CCK and the excitatory amino acid glutamate. First, the effects of CCK were more delayed in onset (∼17 sec) and prolonged in duration (∼124 sec). Second, the depolarizations produced by glutamate were of larger magnitude and associated with variable effects on membrane conductance. Third, the response to CCK showed tachyphylaxis with repeated applications whereas glutamate remained effective as often as it was applied. It is concluded that CCK facilitates the excitability of spinal neurons in a manner distinct from that of the conventional excitant glutamate." @default.
• W1977599327 created "2016-06-24" @default.
• W1977599327 creator A5004551722 @default.
• W1977599327 date "1982-05-01" @default.
• W1977599327 modified "2023-09-27" @default.
• W1977599327 title "Cholecystokinin octapeptide: Effects on the excitability of cultured spinal neurons" @default.
• W1977599327 cites W164162904 @default.
• W1977599327 cites W1682371140 @default.
• W1977599327 cites W1848946457 @default.
• W1977599327 cites W1890478772 @default.
• W1977599327 cites W1968115871 @default.
• W1977599327 cites W1972416469 @default.
• W1977599327 cites W1974213611 @default.
• W1977599327 cites W1976197643 @default.
• W1977599327 cites W1977442367 @default.
• W1977599327 cites W1984330748 @default.
• W1977599327 cites W1987792073 @default.
• W1977599327 cites W1995499904 @default.
• W1977599327 cites W1997337233 @default.
• W1977599327 cites W2002707645 @default.
• W1977599327 cites W2011697056 @default.
• W1977599327 cites W2018299299 @default.
• W1977599327 cites W2030310376 @default.
• W1977599327 cites W2034080924 @default.
• W1977599327 cites W2035856095 @default.
• W1977599327 cites W2036483598 @default.
• W1977599327 cites W2043181244 @default.
• W1977599327 cites W2049131160 @default.
• W1977599327 cites W2056274920 @default.
• W1977599327 cites W2058423921 @default.
• W1977599327 cites W2063304597 @default.
• W1977599327 cites W2065210810 @default.
• W1977599327 cites W2066462196 @default.
• W1977599327 cites W2069695001 @default.
• W1977599327 cites W2071948811 @default.
• W1977599327 cites W2072210371 @default.
• W1977599327 cites W2072810810 @default.
• W1977599327 cites W2073688867 @default.
• W1977599327 cites W2074909561 @default.
• W1977599327 cites W2077449996 @default.
• W1977599327 cites W2080101710 @default.
• W1977599327 cites W2092207123 @default.
• W1977599327 cites W2126149194 @default.
• W1977599327 cites W2771772891 @default.
• W1977599327 doi "https://doi.org/10.1016/0196-9781(82)90124-3" @default.
• W1977599327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6126867" @default.
• W1977599327 hasPublicationYear "1982" @default.
• W1977599327 type Work @default.
• W1977599327 sameAs 1977599327 @default.
• W1977599327 citedByCount "43" @default.
• W1977599327 crossrefType "journal-article" @default.
• W1977599327 hasAuthorship W1977599327A5004551722 @default.
• W1977599327 hasConcept C112592302 @default.
• W1977599327 hasConcept C12554922 @default.
• W1977599327 hasConcept C126322002 @default.
• W1977599327 hasConcept C134018914 @default.
• W1977599327 hasConcept C168481208 @default.
• W1977599327 hasConcept C170493617 @default.
• W1977599327 hasConcept C17077164 @default.
• W1977599327 hasConcept C181911157 @default.
• W1977599327 hasConcept C185592680 @default.
• W1977599327 hasConcept C2777593968 @default.
• W1977599327 hasConcept C4141045 @default.
• W1977599327 hasConcept C55493867 @default.
• W1977599327 hasConcept C61174792 @default.
• W1977599327 hasConcept C71924100 @default.
• W1977599327 hasConcept C79879829 @default.
• W1977599327 hasConcept C86803240 @default.
• W1977599327 hasConceptScore W1977599327C112592302 @default.
• W1977599327 hasConceptScore W1977599327C12554922 @default.
• W1977599327 hasConceptScore W1977599327C126322002 @default.
• W1977599327 hasConceptScore W1977599327C134018914 @default.
• W1977599327 hasConceptScore W1977599327C168481208 @default.
• W1977599327 hasConceptScore W1977599327C170493617 @default.
• W1977599327 hasConceptScore W1977599327C17077164 @default.
• W1977599327 hasConceptScore W1977599327C181911157 @default.
• W1977599327 hasConceptScore W1977599327C185592680 @default.
• W1977599327 hasConceptScore W1977599327C2777593968 @default.
• W1977599327 hasConceptScore W1977599327C4141045 @default.
• W1977599327 hasConceptScore W1977599327C55493867 @default.
• W1977599327 hasConceptScore W1977599327C61174792 @default.
• W1977599327 hasConceptScore W1977599327C71924100 @default.
• W1977599327 hasConceptScore W1977599327C79879829 @default.
• W1977599327 hasConceptScore W1977599327C86803240 @default.
• W1977599327 hasIssue "3" @default.
• W1977599327 hasLocation W19775993271 @default.
• W1977599327 hasLocation W19775993272 @default.
• W1977599327 hasOpenAccess W1977599327 @default.
• W1977599327 hasPrimaryLocation W19775993271 @default.
• W1977599327 hasRelatedWork W1205520864 @default.
• W1977599327 hasRelatedWork W1977599327 @default.
• W1977599327 hasRelatedWork W1986781281 @default.
• W1977599327 hasRelatedWork W1997308927 @default.
• W1977599327 hasRelatedWork W2004045075 @default.
• W1977599327 hasRelatedWork W2019389360 @default.
• W1977599327 hasRelatedWork W2023367531 @default.
• W1977599327 hasRelatedWork W2045925975 @default.
• W1977599327 hasRelatedWork W2120801278 @default.

• next