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- W1977603973 abstract "The functional imaging techniques of positron emission tomography (PET) and single photon emission tomography (SPET) have been used to study regional brain function in Huntington's disease (HD) in vivo. Reduced striatal glucose metabolism and dopamine receptor binding are evident in all symptomatic HD patients and in ∼50% of asymptomatic adult mutation carriers. These characteristics correlate with clinical measures of disease severity. Reduced cortical glucose metabolism and dopamine receptor binding, together with reduced striatal and cortical opioid receptor binding, have also been demonstrated in symptomatic patients with HD. Repeat PET measures of striatal function have been used to monitor the progression of this disease objectively. In the future, functional imaging will provide a valuable way of assessing the efficacy of both fetal striatal cell implants and putative neuroprotective agents, such as nerve growth factors." @default.
- W1977603973 created "2016-06-24" @default.
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- W1977603973 date "1998-12-01" @default.
- W1977603973 modified "2023-09-25" @default.
- W1977603973 title "Advances in the understanding of early Huntington's disease using the functional imaging techniques of PET and SPET" @default.
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- W1977603973 doi "https://doi.org/10.1016/s1357-4310(98)01371-9" @default.
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