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- W1977605220 abstract "An infant with recurrent purpura fulminans in the first year of life was found to have severe homozygous deficiency of protein C (<1% of normal levels). The episodes of purpura fulminans were controlled by infusions of fresh frozen plasma containing protein C. The requirement of frequent plasma infusions, however, eventually resulted in several complications secondary to hyperproteinemia. Factor IX concentrates rich in protein C were then given to maintain adequate levels of the factor while minimizing the amount of extraneous proteins. The patient has remained asymptomatic and free of complications for > 10 months while receiving these concentrates every 48 hours. An infant with recurrent purpura fulminans in the first year of life was found to have severe homozygous deficiency of protein C (<1% of normal levels). The episodes of purpura fulminans were controlled by infusions of fresh frozen plasma containing protein C. The requirement of frequent plasma infusions, however, eventually resulted in several complications secondary to hyperproteinemia. Factor IX concentrates rich in protein C were then given to maintain adequate levels of the factor while minimizing the amount of extraneous proteins. The patient has remained asymptomatic and free of complications for > 10 months while receiving these concentrates every 48 hours." @default.
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- W1977605220 date "1984-09-01" @default.
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- W1977605220 title "Severe homozygous protein C deficiency" @default.
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- W1977605220 doi "https://doi.org/10.1016/s0022-3476(84)80013-x" @default.
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