FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977605821> ?p ?o ?g. }

• W1977605821 endingPage "98" @default.
• W1977605821 startingPage "89" @default.
• W1977605821 abstract "The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the liver of C57BL/6J mice is a model for clinical sporadic porphyria cutanea tarda (PCT). There is massive uroporphyria, inhibition of uroporphyrinogen decarboxylase (UROD) activity, and hepatocellular damage. A variety of evidence implicates the CYP1A2 enzyme as necessary for mouse uroporphyria. Here we report that, 5 weeks after a single oral dose of TCDD (75 μg/kg), Cyp1a2(+/+) wild-type mice showed severe uroporphyria and greater than 90% decreases in UROD activity; in contrast, despite exposure to this potent agent Cyp1a2(−/−) knockout mice displayed absolutely no increases in hepatic porphyrin levels, even after prior iron overload, and no detectable inhibition of UROD activity. Plasma levels of alanine-aminotransferase (ALT) and aspartate aminotransferase (AST)–although elevated in both genotypes after TCDD exposure–were significantly less in Cyp1a2(−/−) than in Cyp1a2(+/+) mice, suggesting that the absence of CYP1A2 also affords partial protection against TCDD-induced liver toxicity. Histological examination confirmed a decrease in hepatocellular damage in TCDD-treated Cyp1a2(−/−) mice; in particular, there was no bile duct damage or proliferation that in the Cyp1a2(+/+) mice might be caused by uroporphyrin. We conclude that CYP1A2 is both necessary and essential for the potent uroporphyrinogenic effects of TCDD in mice, and that CYP1A2 also plays a role in contributing to TCDD-induced hepatocellular injury. This study has implications for both the toxicity assessment of TCDD and the hepatic injury seen in PCT patients." @default.
• W1977605821 created "2016-06-24" @default.
• W1977605821 creator A5004567313 @default.
• W1977605821 creator A5029237881 @default.
• W1977605821 creator A5032404713 @default.
• W1977605821 creator A5033550773 @default.
• W1977605821 creator A5075999388 @default.
• W1977605821 creator A5078329639 @default.
• W1977605821 creator A5084982528 @default.
• W1977605821 date "2001-06-01" @default.
• W1977605821 modified "2023-10-15" @default.
• W1977605821 title "Protection of the Cyp1a2(−/−) Null Mouse against Uroporphyria and Hepatic Injury Following Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin" @default.
• W1977605821 cites W1269501328 @default.
• W1977605821 cites W1702997048 @default.
• W1977605821 cites W1820908299 @default.
• W1977605821 cites W1858015527 @default.
• W1977605821 cites W1943047487 @default.
• W1977605821 cites W1963155846 @default.
• W1977605821 cites W1974135984 @default.
• W1977605821 cites W1977538957 @default.
• W1977605821 cites W1986928947 @default.
• W1977605821 cites W1993432387 @default.
• W1977605821 cites W1996587450 @default.
• W1977605821 cites W2008082586 @default.
• W1977605821 cites W2017240808 @default.
• W1977605821 cites W2022491680 @default.
• W1977605821 cites W2026550655 @default.
• W1977605821 cites W2026987279 @default.
• W1977605821 cites W2035575097 @default.
• W1977605821 cites W2037008348 @default.
• W1977605821 cites W2038265456 @default.
• W1977605821 cites W2041727071 @default.
• W1977605821 cites W2042711678 @default.
• W1977605821 cites W2043206875 @default.
• W1977605821 cites W2044559083 @default.
• W1977605821 cites W2045931107 @default.
• W1977605821 cites W2048541682 @default.
• W1977605821 cites W2050458591 @default.
• W1977605821 cites W2056096642 @default.
• W1977605821 cites W2056588489 @default.
• W1977605821 cites W2062869817 @default.
• W1977605821 cites W2063373861 @default.
• W1977605821 cites W2069311689 @default.
• W1977605821 cites W2070674364 @default.
• W1977605821 cites W2072095457 @default.
• W1977605821 cites W2073174034 @default.
• W1977605821 cites W2075634723 @default.
• W1977605821 cites W2077218577 @default.
• W1977605821 cites W2079745478 @default.
• W1977605821 cites W2081167845 @default.
• W1977605821 cites W2081912110 @default.
• W1977605821 cites W2083880470 @default.
• W1977605821 cites W2086541189 @default.
• W1977605821 cites W2089206345 @default.
• W1977605821 cites W2089288530 @default.
• W1977605821 cites W2091464815 @default.
• W1977605821 cites W2091699095 @default.
• W1977605821 cites W2092235355 @default.
• W1977605821 cites W2097280446 @default.
• W1977605821 cites W2097694649 @default.
• W1977605821 cites W2108696732 @default.
• W1977605821 cites W2114030946 @default.
• W1977605821 cites W2114629114 @default.
• W1977605821 cites W2127966331 @default.
• W1977605821 cites W2130821715 @default.
• W1977605821 cites W2133972226 @default.
• W1977605821 cites W2134264887 @default.
• W1977605821 cites W2136223951 @default.
• W1977605821 cites W2146909058 @default.
• W1977605821 cites W2155310231 @default.
• W1977605821 cites W2165627850 @default.
• W1977605821 doi "https://doi.org/10.1006/taap.2001.9167" @default.
• W1977605821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11384210" @default.
• W1977605821 hasPublicationYear "2001" @default.
• W1977605821 type Work @default.
• W1977605821 sameAs 1977605821 @default.
• W1977605821 citedByCount "86" @default.
• W1977605821 countsByYear W19776058212012 @default.
• W1977605821 countsByYear W19776058212013 @default.
• W1977605821 countsByYear W19776058212014 @default.
• W1977605821 countsByYear W19776058212017 @default.
• W1977605821 countsByYear W19776058212018 @default.
• W1977605821 countsByYear W19776058212019 @default.
• W1977605821 countsByYear W19776058212020 @default.
• W1977605821 crossrefType "journal-article" @default.
• W1977605821 hasAuthorship W1977605821A5004567313 @default.
• W1977605821 hasAuthorship W1977605821A5029237881 @default.
• W1977605821 hasAuthorship W1977605821A5032404713 @default.
• W1977605821 hasAuthorship W1977605821A5033550773 @default.
• W1977605821 hasAuthorship W1977605821A5075999388 @default.
• W1977605821 hasAuthorship W1977605821A5078329639 @default.
• W1977605821 hasAuthorship W1977605821A5084982528 @default.
• W1977605821 hasConcept C126322002 @default.
• W1977605821 hasConcept C134018914 @default.
• W1977605821 hasConcept C185592680 @default.
• W1977605821 hasConcept C2781223928 @default.
• W1977605821 hasConcept C29730261 @default.
• W1977605821 hasConcept C526171541 @default.

• next