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• W1977609099 abstract "Cardiovascular inhibitory effects induced by intrathecal (i.t.) administration of adenosine A1 receptor agonist and its modulation by cyclic AMP was suggested by our previous report. In this experiment, we examined the mediation of cardiovascular effects of adenosine A1 receptor by γ-aminobutyric acid receptors A and B (GABAA and GABAB) in the spinal cord. I.t. administration of 10 nmol of N6-cyclohexyladenosine (CHA), an adenosine A1 receptor agonist, and pretreatment with bicuculline (10 nmol, i.t), a GABAA receptor antagonist, and 5-aminovaleric acid (50 nmol, i.t.), a GABAB receptor antagonist, prior to injection of CHA were performed in anesthetized, artificially ventilated Sprague–Dawley rats. I.t. injection of 50 nmol of 5-aminovaleric acid significantly attenuated the inhibitory cardiovascular effects of CHA but 10 nmol of bicuculline did not alter CHA-induced cardiovascular actions. It is suggested that cardiovascular responses of adenosine A1 receptor is meditated by GABAB receptor in the spinal cord." @default.
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• W1977609099 date "1998-02-01" @default.
• W1977609099 modified "2023-09-25" @default.
• W1977609099 title "Mediation of the cardiovascular response of adenosine A1 receptor through a GABAB receptor in the spinal cord of the rats" @default.
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• W1977609099 doi "https://doi.org/10.1016/s0304-3940(98)00089-5" @default.
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