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- W1977611628 endingPage "160" @default.
- W1977611628 startingPage "151" @default.
- W1977611628 abstract "The protein cargo transported by specific types of vesicles largely defines the different secretory trafficking pathways operating within cells. However, mole per mole the most abundant cargo contained within transport vesicles is not protein, but lipid. Taking a lipid-centric point-of-view, we examine the importance of lipid signaling, membrane lipid organization and lipid metabolism for vesicle transport during exocytosis in budding yeast. In fact, the essential requirement for some exocytosis regulatory proteins can be bypassed by making simple manipulations of the lipids involved. During polarized exocytosis the sequential steps required to generate post-Golgi vesicles and target them to the plasma membrane (PM) involves the interplay of several types of lipids that are coordinately linked through PI4P metabolism and signaling. In turn, PI4P levels are regulated by PI4P kinases, the Sac1p PI4P phosphatase and the yeast Osh proteins, which are homologs of mammalian oxysterol-binding protein (OSBP). Together these regulators integrate the transitional steps required for vesicle maturation directly through changes in lipid composition and organization." @default.
- W1977611628 created "2016-06-24" @default.
- W1977611628 creator A5012256170 @default.
- W1977611628 creator A5037259685 @default.
- W1977611628 creator A5060113602 @default.
- W1977611628 date "2012-07-01" @default.
- W1977611628 modified "2023-10-01" @default.
- W1977611628 title "Vesicle trafficking from a lipid perspective" @default.
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