FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977623445> ?p ?o ?g. }

• W1977623445 endingPage "3190" @default.
• W1977623445 startingPage "3181" @default.
• W1977623445 abstract "1 The role of the central renin-angiotensin system in the pathogenesis of hypertension in spontaneously hypertensive rats (SHR) was examined following acute and chronic intracerebroventricular (i.c.v.) infusions of angiotensin1 (AT1) receptor antagonists. 2 Groups of SHR were chronically instrumented for acute i.c.v. administration of the AT1 receptor antagonists, losartan and CV-11974, on mean arterial blood pressure (MAP) and heart rate (HR). Other groups of SHR also had mini-osmotic pumps implanted for chronic i.c.v. infusion of CV-11974. 3 Initially both young (15–18 weeks, n = 8) and old (25–29 weeks, n = 9) SHR received acute i.c.v. injections of losartan (10 μg) while a third group of young SHR received CV-11974 (1 μg, n = 6). In all three groups of SHR, MAP and HR did not change up to 24 h after antagonist injection. However, changes in MAP and HR in response to i.c.v. angiotensin II (AII, 100 ng) were abolished 15 min after administration of the AT1 receptor antagonists. These responses had returned to control levels after 3 h in both groups given losartan but were still significantly depressed at 24 h in the CV-11974-treated group. By contrast, responses to i.v. AII (25 ng) before and 1 h after administration of AT1 receptor antagonists were not significantly different.4 For chronic studies, four groups of SHR received chronic i.c.v. infusion of either vehicle (n = 9) or CV-11974 (1, 5 and 100 μg kg−1 day−1) (n = 4, 7 and 8 respectively) for 4 days. Baseline cardiovascular parameters were monitored daily together with changes in MAP and HR in response to both i.c.v. and i.v. AII (100 ng and 50 ng respectively) and i.v. phenylephrine (3 μg). Responses to i.c.v. carbachol (5 μg) were also recorded on day 4 while barorefiex function was assessed between days 1–3. In SHR treated chronically with i.c.v. vehicle or CV-11974, at 1 or 5 μg kg−1 day−1, resting MAP and HR did not vary over the four day infusion period. However, SHR treated with 100 μg kg−1 day−1 CV-11974 had significantly lower MAP compared to vehicle-treated SHR. While there was some variation in resting HR, there were no differences between the drug-treated and vehicle-treated groups. Pressor responses following i.c.v. AII administration were slightly, but significantly, inhibited on days 3 and 4 in the low dose CV-11974-treated (1 μg kg−1 day−1) SHR. However, these responses were abolished on all 4 days in the 5 and 100 μg kg−1 day−1 CV-11974-treated groups. By contrast, changes in MAP and HR following i.v. AII injection did not vary over the 4 day infusion between SHR treated with the 2 lowest doses of CV-11974 and the vehicle-treated group. However, in the high dose CV-11974-treated SHR (100 μg kg−1 day−1), the cardiovascular effects of AII were abolished. In addition, phenylephrine (i.v.) and carbachol (i.c.v.) induced changes in MAP and HR were not significantly different in all four treatment groups. Similarly, baroreflex function was unaffected by i.c.v. infusion of 100 μg kg−1 day−1 CV-11974, except for a significant fall in BP50 which paralleled the fall in resting MAP. 5 Collectively, these results indicate that acute and chronic central AT1 receptor antagonism does not lower MAP in conscious SHR in doses which only block central AII-induced pressor activity. Chronic central infusion of CV-11974 at sufficiently high doses will lower MAP, as has been reported by others, but not without the abolition of the peripheral effects of AII Therefore it is most likely that peripheral AT1 receptor blockade contributes to the hypotensive action of CV-11974 under these conditions." @default.
• W1977623445 created "2016-06-24" @default.
• W1977623445 creator A5001574774 @default.
• W1977623445 creator A5070440854 @default.
• W1977623445 date "1995-12-01" @default.
• W1977623445 modified "2023-09-29" @default.
• W1977623445 title "Lack of a centrally-mediated antihypertensive effect following acute or chronic central treatment with AT1-receptor antagonists in spontaneously hypertensive rats" @default.
• W1977623445 cites W1891400372 @default.
• W1977623445 cites W1964816832 @default.
• W1977623445 cites W1966421966 @default.
• W1977623445 cites W1974072853 @default.
• W1977623445 cites W1974981394 @default.
• W1977623445 cites W1983904334 @default.
• W1977623445 cites W1987168691 @default.
• W1977623445 cites W1994003684 @default.
• W1977623445 cites W1997057063 @default.
• W1977623445 cites W2009843354 @default.
• W1977623445 cites W2020680347 @default.
• W1977623445 cites W2032728512 @default.
• W1977623445 cites W2037155741 @default.
• W1977623445 cites W2037524930 @default.
• W1977623445 cites W2043032068 @default.
• W1977623445 cites W2045000221 @default.
• W1977623445 cites W2058710601 @default.
• W1977623445 cites W2060381190 @default.
• W1977623445 cites W2064654672 @default.
• W1977623445 cites W2070534059 @default.
• W1977623445 cites W2076030580 @default.
• W1977623445 cites W2079132953 @default.
• W1977623445 cites W2088731167 @default.
• W1977623445 cites W2101601744 @default.
• W1977623445 cites W2116781041 @default.
• W1977623445 cites W2133601979 @default.
• W1977623445 cites W2145879452 @default.
• W1977623445 cites W2148681534 @default.
• W1977623445 cites W2154885779 @default.
• W1977623445 cites W2155369856 @default.
• W1977623445 cites W2181173018 @default.
• W1977623445 cites W2203435655 @default.
• W1977623445 cites W2264834865 @default.
• W1977623445 cites W2332965800 @default.
• W1977623445 cites W2411873856 @default.
• W1977623445 cites W2467998847 @default.
• W1977623445 cites W2474103501 @default.
• W1977623445 doi "https://doi.org/10.1111/j.1476-5381.1995.tb15122.x" @default.
• W1977623445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1909159" @default.
• W1977623445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8719794" @default.
• W1977623445 hasPublicationYear "1995" @default.
• W1977623445 type Work @default.
• W1977623445 sameAs 1977623445 @default.
• W1977623445 citedByCount "21" @default.
• W1977623445 countsByYear W19776234452013 @default.
• W1977623445 countsByYear W19776234452014 @default.
• W1977623445 countsByYear W19776234452015 @default.
• W1977623445 countsByYear W19776234452016 @default.
• W1977623445 countsByYear W19776234452018 @default.
• W1977623445 countsByYear W19776234452020 @default.
• W1977623445 crossrefType "journal-article" @default.
• W1977623445 hasAuthorship W1977623445A5001574774 @default.
• W1977623445 hasAuthorship W1977623445A5070440854 @default.
• W1977623445 hasBestOaLocation W19776234452 @default.
• W1977623445 hasConcept C123915805 @default.
• W1977623445 hasConcept C126322002 @default.
• W1977623445 hasConcept C134018914 @default.
• W1977623445 hasConcept C170493617 @default.
• W1977623445 hasConcept C198710026 @default.
• W1977623445 hasConcept C2776885963 @default.
• W1977623445 hasConcept C2778122271 @default.
• W1977623445 hasConcept C2780288358 @default.
• W1977623445 hasConcept C2780708007 @default.
• W1977623445 hasConcept C2908929049 @default.
• W1977623445 hasConcept C71924100 @default.
• W1977623445 hasConcept C84393581 @default.
• W1977623445 hasConceptScore W1977623445C123915805 @default.
• W1977623445 hasConceptScore W1977623445C126322002 @default.
• W1977623445 hasConceptScore W1977623445C134018914 @default.
• W1977623445 hasConceptScore W1977623445C170493617 @default.
• W1977623445 hasConceptScore W1977623445C198710026 @default.
• W1977623445 hasConceptScore W1977623445C2776885963 @default.
• W1977623445 hasConceptScore W1977623445C2778122271 @default.
• W1977623445 hasConceptScore W1977623445C2780288358 @default.
• W1977623445 hasConceptScore W1977623445C2780708007 @default.
• W1977623445 hasConceptScore W1977623445C2908929049 @default.
• W1977623445 hasConceptScore W1977623445C71924100 @default.
• W1977623445 hasConceptScore W1977623445C84393581 @default.
• W1977623445 hasIssue "8" @default.
• W1977623445 hasLocation W19776234451 @default.
• W1977623445 hasLocation W19776234452 @default.
• W1977623445 hasLocation W19776234453 @default.
• W1977623445 hasLocation W19776234454 @default.
• W1977623445 hasOpenAccess W1977623445 @default.
• W1977623445 hasPrimaryLocation W19776234451 @default.
• W1977623445 hasRelatedWork W1993740987 @default.
• W1977623445 hasRelatedWork W2031648463 @default.
• W1977623445 hasRelatedWork W2035737952 @default.
• W1977623445 hasRelatedWork W2038571733 @default.
• W1977623445 hasRelatedWork W2043032068 @default.
• W1977623445 hasRelatedWork W2060187831 @default.

• next