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• W1977656458 abstract "An analysis of the nucleic acid and protein composition of endometrial tissue was undertaken in normal women and in patients using either steroidal oral contraceptives or intrauterine contraceptive devices (IUCD). In the presence of an IUCD, endometrial RNA/DNA and protein/DNA ratios were elevated in the secretory phase of the menstrual cycle compared to values obtained in normal women. In the oral contraceptive group, endometrial RNA/DNA and protein/DNA ratios were below the normal range in the late proliferative phase of the cycle. Typical electrophoretic profiles in the oral contraceptive group were similar to the control group, although a quantitative analysis revealed that the concentrations of certain characteristic uterine proteins were reduced. In the IUCD group, there was a preferential appearance of two proteins with approximate molecular weights of 36,000 and 26,000 daltons. Another protein with a molecular weight of 48,000 daltons, which demonstrated a cyclic change during the normal menstrual cycle, was reduced in both study groups. The results suggest that both agents studied induce changes in the macromolecular composition of the human endometrium which may relate to their contraceptive effect.Nucleic acid and protein composition of endometrial tissue taken from normal women and patients using either oral contraceptives (OCs) or IUDs was analyzed in this comparative study. Endometrial ribonucleic acid (RNA)/deoxyribonucleic acid (DNA) and protein/DNA ratios were elevated in the presence of IUDs during the secretory phase of the menstrual cycle compared to values obtained in normal women. In OC users, endometrial RNA/DNA and protein/DNA ratios were below the normal range in the late proliferative cycle phase. Electrophoretic profiles of endometria were also performed. Typical electrophoretic profiles in the OC group were similar to controls, although a quantitative analysis revealed that the concentrations of certain characteristic uterine proteins were reduced in OC users. In contrast, there was a preferential appearance of 2 proteins in the IUD group; these proteins had approximate molecular weights of 36,000 and 26,000 daltons, respectively. A 48,000-dalton protein, which demonstrated a cyclic change during the normal menstrual cycle, was reduced in both IUD and OC users. Therefore, it is concluded that both types of contraception induce changes in the macromolecular composition of human endometrium, and that these changes may be related to their contraceptive modes of action." @default.
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• W1977656458 date "1980-10-01" @default.
• W1977656458 modified "2023-09-27" @default.
• W1977656458 title "Effects of contraceptive agents on the biochemical and protein composition of human endometrium" @default.
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• W1977656458 doi "https://doi.org/10.1016/0010-7824(80)90027-x" @default.
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