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- W1977658352 abstract "Previous studies have demonstrated that human alveolar and bone marrow macrophages when activated in vitro can metabolize 25-hydroxyvitamin[3H]D3 to 1α,25-dihydroxyvitamin[3H]D3; however, to date no animal models to study this system have been available. In the present study, cultured porcine pulmonary alveolar macrophages from two animals were assayed for their capability for metabolism of 25-hydroxy-vitamin[3H]D3. The porcine alveolar macrophages constitutively produced a metabolite of 25-hydroxy-vitamin[3H]D3 which was identified as 1α,25-dihydroxyvitamin[3H]D3 by high performance liquid chromatography. The apparent KM was in the range of 300 nM. Unlike human macrophages, treatment of porcine alveolar macrophages with lipopolysaccharide did not stimulate lα,25-dihydroxyvitamin[3H]D3 production. Addition of 1α,25-dihydroxyvitamin-D3 to macrophages cultures led to a sensitive proportional inhibition of 1α,25-dihydroxyvitamin[3H]D3 synthesis." @default.
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- W1977658352 date "1991-02-01" @default.
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- W1977658352 title "Evidence for 1,25-dihydroxyvitamin D3 production by cultured porcine alveolar macrophages" @default.
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- W1977658352 doi "https://doi.org/10.1016/0303-7207(91)90231-g" @default.
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