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- W1977663635 abstract "Guinea pigs were fed a diet containing cholesterol-4-C14 for several weeks in order to establish isotopic equilibrium with respect to (a) labeled cholesterol in the adrenal glands and other tissues and (b) labeled cortisol in the urine. In the guinea pig, about 60% of adrenal gland cholesterol was derived from plasma. In this respect the guinea pig differs from the rat, in which practically all adrenal gland cholesterol is derived from plasma. Only 13% of testicular cholesterol was derived from plasma. Evidence compatible with the view that adrenal gland cholesterol is the principal precursor of urinary cortisol in the guinea pig is presented. ACTH treatments that increased the daily excretion of cortisol in urine about threefold failed to alter the values for (a) the ratio of the specific activitiy of adrenal cholesterol to that of blood cholesterol and (b) the ratio of the specific activity of urinary cortisol to that of adrenal cholesterol. These findings are consistent with the view that ACTH administration does not induce a new pathway of synthesis of urinary cortisol but, rather, speeds up an existing pathway from adrenal gland cholesterol." @default.
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- W1977663635 date "1961-06-01" @default.
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- W1977663635 title "Utilization of adrenal gland cholesterol for synthesis of cortisol by the intact normal and the ACTH-treated guinea pig" @default.
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- W1977663635 doi "https://doi.org/10.1016/s0003-9861(61)80039-8" @default.
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