Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977672191> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1977672191 endingPage "135" @default.
- W1977672191 startingPage "132" @default.
- W1977672191 abstract "Eotaxin is an eosinophil-specific chemokine associated with the recruitment of eosinophils to sites of allergic inflammation. Saiboku-to (Formula magnoliae et bupleuri) is a kampo herbal medicine used for the treatment of bronchial asthma in Japan. In this study, we investigated the effects of Scutellaria Root, a major herb in Saiboku-to and its components such as baicalein and baicalin on eotaxin production by IL-4 plus TNF-alpha-stimulated human fibroblasts. An extract of Scutellaria Root markedly inhibited eotaxin production. Four major flavonoids from Scutellaria Root were found to show inhibitory activity on eotaxin production at a concentration of 10 micrograms/ml in the order of baicalein > oroxylin A > baicalin > skullcapflavon II. The inhibitory effect of baicalein was expressed in a dose-dependent manner, and almost 50% inhibition was observed at 1.8 micrograms/ml. Furthermore, baicalein prevented human eotaxin mRNA expression in IL-4 plus TNF-alpha-stimulated human fibroblasts. These results help explain the pharmacological efficacy of Scutellaria Root in the treatment of bronchial asthma since it would suppress eotaxin associated recruitment of eosinophils." @default.
- W1977672191 created "2016-06-24" @default.
- W1977672191 creator A5009023927 @default.
- W1977672191 creator A5019545541 @default.
- W1977672191 creator A5059336308 @default.
- W1977672191 creator A5064181679 @default.
- W1977672191 creator A5076883896 @default.
- W1977672191 date "2001-03-01" @default.
- W1977672191 modified "2023-10-02" @default.
- W1977672191 title "Inhibitory Effect of Baicalein, a Flavonoid in Scutellaria Root, on Eotaxin Production by Human Dermal Fibroblasts" @default.
- W1977672191 doi "https://doi.org/10.1055/s-2001-11532" @default.
- W1977672191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11301858" @default.
- W1977672191 hasPublicationYear "2001" @default.
- W1977672191 type Work @default.
- W1977672191 sameAs 1977672191 @default.
- W1977672191 citedByCount "56" @default.
- W1977672191 countsByYear W19776721912012 @default.
- W1977672191 countsByYear W19776721912013 @default.
- W1977672191 countsByYear W19776721912014 @default.
- W1977672191 countsByYear W19776721912015 @default.
- W1977672191 countsByYear W19776721912016 @default.
- W1977672191 countsByYear W19776721912017 @default.
- W1977672191 countsByYear W19776721912018 @default.
- W1977672191 countsByYear W19776721912019 @default.
- W1977672191 countsByYear W19776721912020 @default.
- W1977672191 countsByYear W19776721912022 @default.
- W1977672191 countsByYear W19776721912023 @default.
- W1977672191 crossrefType "journal-article" @default.
- W1977672191 hasAuthorship W1977672191A5009023927 @default.
- W1977672191 hasAuthorship W1977672191A5019545541 @default.
- W1977672191 hasAuthorship W1977672191A5059336308 @default.
- W1977672191 hasAuthorship W1977672191A5064181679 @default.
- W1977672191 hasAuthorship W1977672191A5076883896 @default.
- W1977672191 hasConcept C13373296 @default.
- W1977672191 hasConcept C142724271 @default.
- W1977672191 hasConcept C179998833 @default.
- W1977672191 hasConcept C185592680 @default.
- W1977672191 hasConcept C188947578 @default.
- W1977672191 hasConcept C203014093 @default.
- W1977672191 hasConcept C204787440 @default.
- W1977672191 hasConcept C2775897108 @default.
- W1977672191 hasConcept C2776914184 @default.
- W1977672191 hasConcept C2777716647 @default.
- W1977672191 hasConcept C2778153525 @default.
- W1977672191 hasConcept C2780113650 @default.
- W1977672191 hasConcept C2781466915 @default.
- W1977672191 hasConcept C43617362 @default.
- W1977672191 hasConcept C556039675 @default.
- W1977672191 hasConcept C71924100 @default.
- W1977672191 hasConcept C98274493 @default.
- W1977672191 hasConceptScore W1977672191C13373296 @default.
- W1977672191 hasConceptScore W1977672191C142724271 @default.
- W1977672191 hasConceptScore W1977672191C179998833 @default.
- W1977672191 hasConceptScore W1977672191C185592680 @default.
- W1977672191 hasConceptScore W1977672191C188947578 @default.
- W1977672191 hasConceptScore W1977672191C203014093 @default.
- W1977672191 hasConceptScore W1977672191C204787440 @default.
- W1977672191 hasConceptScore W1977672191C2775897108 @default.
- W1977672191 hasConceptScore W1977672191C2776914184 @default.
- W1977672191 hasConceptScore W1977672191C2777716647 @default.
- W1977672191 hasConceptScore W1977672191C2778153525 @default.
- W1977672191 hasConceptScore W1977672191C2780113650 @default.
- W1977672191 hasConceptScore W1977672191C2781466915 @default.
- W1977672191 hasConceptScore W1977672191C43617362 @default.
- W1977672191 hasConceptScore W1977672191C556039675 @default.
- W1977672191 hasConceptScore W1977672191C71924100 @default.
- W1977672191 hasConceptScore W1977672191C98274493 @default.
- W1977672191 hasIssue "2" @default.
- W1977672191 hasLocation W19776721911 @default.
- W1977672191 hasLocation W19776721912 @default.
- W1977672191 hasOpenAccess W1977672191 @default.
- W1977672191 hasPrimaryLocation W19776721911 @default.
- W1977672191 hasRelatedWork W1977672191 @default.
- W1977672191 hasRelatedWork W2000815058 @default.
- W1977672191 hasRelatedWork W2024980041 @default.
- W1977672191 hasRelatedWork W2033056106 @default.
- W1977672191 hasRelatedWork W2050816864 @default.
- W1977672191 hasRelatedWork W2292402720 @default.
- W1977672191 hasRelatedWork W3006895096 @default.
- W1977672191 hasRelatedWork W3116588626 @default.
- W1977672191 hasRelatedWork W3154249688 @default.
- W1977672191 hasRelatedWork W4254383866 @default.
- W1977672191 hasVolume "67" @default.
- W1977672191 isParatext "false" @default.
- W1977672191 isRetracted "false" @default.
- W1977672191 magId "1977672191" @default.
- W1977672191 workType "article" @default.