FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977674519> ?p ?o ?g. }

• W1977674519 endingPage "1352" @default.
• W1977674519 startingPage "1346" @default.
• W1977674519 abstract "Thyroid hormone exerts its biological effect by binding to a TR. Both liganded and unliganded TRs regulate the transcription of T(3)-responsive genes. Cofactors with activating or repressing function modulate the transcriptional regulation by TRs. We showed that steroid receptor coactivator 1 (SRC-1)-deficient mice (SRC-1(-/-)) exhibit partial resistance to thyroid hormone at the level of the pituitary thyrotrophs. To determine whether SRC-1 deficiency affects globally T(3)-dependent transcriptional regulation, we studied the effects of thyroid hormone deprivation and replacement on the expression of several genes in different tissues of SRC-1(-/-) and wild-type mice (SRC-1(+/+)). Thyroid hormone deficiency was induced by a low iodine diet (LoI) supplemented with propylthiouracil (PTU) for 2 wk. L-T(3) was injected ip for the last 4 d in one group (PTU+T(3) group), and another group (PTU group) received only vehicle. Levels of mRNAs for T(3)-responsive genes were determined by Northern blotting: GH and TSH beta in pituitary; type 1 iodothyronine 5'-deiodinase, spot 14 (S14), and malic enzyme in liver; and sarcoplasmic reticulum calcium adenosine triphosphatase 2 and myosin heavy chain alpha and beta in heart. Serum parameters, TSH, total cholesterol, creatine kinase, and alkaline phosphatase (AP), were also measured. Hypothyroidism produced a comparable increase in TSH beta mRNA in both genotypes, but its suppression by L-T(3) was attenuated in SRC-1(-/-) mice. In contrast, hypothyroidism failed to reduce S14 mRNA levels in SRC-1(-/-) mice. As a consequence, the response to L-T(3) was not observed in these mice. SRC-1 deficiency had no effect on the expression of the rest of the T(3)-responsive genes examined. Of the four serum parameters, the T(3)-mediated decrease in TSH and changes in AP were attenuated in SRC-1(-/-) mice. We conclude that SRC-1 deficiency altered the expression of only some of the T(3)-responsive genes. SRC-1 appears to be involved not only in transcriptional activation by liganded TRs, but also in the suppression by liganded or unliganded TRs. Some of the effects of SRC-1 may be TR isoform specific." @default.
• W1977674519 created "2016-06-24" @default.
• W1977674519 creator A5009652523 @default.
• W1977674519 creator A5030162924 @default.
• W1977674519 creator A5038183050 @default.
• W1977674519 creator A5041163845 @default.
• W1977674519 creator A5045436318 @default.
• W1977674519 creator A5052751245 @default.
• W1977674519 creator A5057978718 @default.
• W1977674519 creator A5072590785 @default.
• W1977674519 creator A5073334494 @default.
• W1977674519 date "2002-04-01" @default.
• W1977674519 modified "2023-10-10" @default.
• W1977674519 title "Steroid Receptor Coactivator-1 Deficiency Causes Variable Alterations in the Modulation of T₃-Regulated Transcription of Genes<i>in Vivo</i>" @default.
• W1977674519 cites W1483275313 @default.
• W1977674519 cites W1493268813 @default.
• W1977674519 cites W1498239088 @default.
• W1977674519 cites W1517725951 @default.
• W1977674519 cites W1521699044 @default.
• W1977674519 cites W1570814048 @default.
• W1977674519 cites W1573975307 @default.
• W1977674519 cites W1593924964 @default.
• W1977674519 cites W1613446635 @default.
• W1977674519 cites W1628693640 @default.
• W1977674519 cites W1646199134 @default.
• W1977674519 cites W1826361194 @default.
• W1977674519 cites W1969391229 @default.
• W1977674519 cites W1981022538 @default.
• W1977674519 cites W1990675136 @default.
• W1977674519 cites W2012155675 @default.
• W1977674519 cites W2016490618 @default.
• W1977674519 cites W2019259772 @default.
• W1977674519 cites W2022485603 @default.
• W1977674519 cites W2034071735 @default.
• W1977674519 cites W2051380306 @default.
• W1977674519 cites W2056806829 @default.
• W1977674519 cites W2056978878 @default.
• W1977674519 cites W2058784350 @default.
• W1977674519 cites W2060128629 @default.
• W1977674519 cites W2064097956 @default.
• W1977674519 cites W2064956340 @default.
• W1977674519 cites W2068113812 @default.
• W1977674519 cites W2073133361 @default.
• W1977674519 cites W2075125622 @default.
• W1977674519 cites W2077437011 @default.
• W1977674519 cites W2082072773 @default.
• W1977674519 cites W2084762536 @default.
• W1977674519 cites W2090024435 @default.
• W1977674519 cites W2094838095 @default.
• W1977674519 cites W2109515577 @default.
• W1977674519 cites W2116865760 @default.
• W1977674519 cites W2121772566 @default.
• W1977674519 cites W2123808456 @default.
• W1977674519 cites W2134812217 @default.
• W1977674519 cites W2136085109 @default.
• W1977674519 cites W2172256092 @default.
• W1977674519 cites W3142477471 @default.
• W1977674519 doi "https://doi.org/10.1210/endo.143.4.8730" @default.
• W1977674519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11897691" @default.
• W1977674519 hasPublicationYear "2002" @default.
• W1977674519 type Work @default.
• W1977674519 sameAs 1977674519 @default.
• W1977674519 citedByCount "45" @default.
• W1977674519 countsByYear W19776745192012 @default.
• W1977674519 countsByYear W19776745192014 @default.
• W1977674519 countsByYear W19776745192015 @default.
• W1977674519 countsByYear W19776745192016 @default.
• W1977674519 countsByYear W19776745192017 @default.
• W1977674519 countsByYear W19776745192018 @default.
• W1977674519 countsByYear W19776745192020 @default.
• W1977674519 countsByYear W19776745192021 @default.
• W1977674519 countsByYear W19776745192023 @default.
• W1977674519 crossrefType "journal-article" @default.
• W1977674519 hasAuthorship W1977674519A5009652523 @default.
• W1977674519 hasAuthorship W1977674519A5030162924 @default.
• W1977674519 hasAuthorship W1977674519A5038183050 @default.
• W1977674519 hasAuthorship W1977674519A5041163845 @default.
• W1977674519 hasAuthorship W1977674519A5045436318 @default.
• W1977674519 hasAuthorship W1977674519A5052751245 @default.
• W1977674519 hasAuthorship W1977674519A5057978718 @default.
• W1977674519 hasAuthorship W1977674519A5072590785 @default.
• W1977674519 hasAuthorship W1977674519A5073334494 @default.
• W1977674519 hasBestOaLocation W19776745191 @default.
• W1977674519 hasConcept C104317684 @default.
• W1977674519 hasConcept C109115496 @default.
• W1977674519 hasConcept C121608353 @default.
• W1977674519 hasConcept C126322002 @default.
• W1977674519 hasConcept C134018914 @default.
• W1977674519 hasConcept C149574134 @default.
• W1977674519 hasConcept C23589133 @default.
• W1977674519 hasConcept C2775960720 @default.
• W1977674519 hasConcept C526584372 @default.
• W1977674519 hasConcept C530470458 @default.
• W1977674519 hasConcept C55493867 @default.
• W1977674519 hasConcept C71924100 @default.
• W1977674519 hasConcept C77445288 @default.
• W1977674519 hasConcept C86339819 @default.
• W1977674519 hasConcept C86803240 @default.

• next