FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977676489> ?p ?o ?g. }

• W1977676489 endingPage "88" @default.
• W1977676489 startingPage "74" @default.
• W1977676489 abstract "Tissue-on-tissue friction testing was used to determine how instillation of hydrophilic polymer-containing formulations between the “blinking” tissues would compare with lubrication by saline, alone, or an oil-emulsion preparation. Best results were obtained for a formulation that contained active demulcents polyethylene glycol (PEG 400) and propylene glycol (PG), as well as a gellable polymer hydroxypropyl guar (HP-Guar) in a borate-buffered solution, in comparison with hydroxypropylcellulose-containing and carboxymethylcellulose-containing formulations. Superior performance of all the formulations was found for lubricating tissue-on-tissue couples, compared with metal-oxide-to-metal oxide interfaces, or metal oxide-to-tissue interfaces. A reciprocating pin-on-disc type friction/wear test device articulated the intimal faces of preserved human umbilical cord vein segments under increasing loads during simulated continuous “eye-blinking” with addition of increasing weights up to 60 g/cm2, simulating maximal eyelid force on the orbital globe. The tissue-on-tissue couples moved from liquid phase lubrication to boundary lubrication. After residual formulations were rinsed away with saline, persistence of low friction at the highest loads was indicative of formulation substantivity. Human umbilical cord vein segments were utilized in saline-wetted tissue-on-tissue couples that showed variable starting coefficients of friction in the range 0.2–0.4, producing moderate tearing and disruption of the interfacial layers above the medial collagen zone. The best-performing formulations instilled to the tissues pre-wetted with saline apparently reacted separately with each tissue face to produce a lower final and persistent coefficient of friction of about 0.05. Scanning electron microscopy and light microscopy of these guar-modified tissue specimens showed only a few superficial tissue disruptions, and some interphase swelling consistent with polymer uptake. The frictional values for lubricated couples having non-tissue members were considerably higher than the coefficients of friction measured for the similarly lubricated tissue-on-tissue couples, emphasizing the requirement that appropriate simulations are critical to obtaining clinically predictive data. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006" @default.
• W1977676489 created "2016-06-24" @default.
• W1977676489 creator A5001043748 @default.
• W1977676489 creator A5008689600 @default.
• W1977676489 creator A5030141577 @default.
• W1977676489 creator A5054512056 @default.
• W1977676489 date "2007-07-01" @default.
• W1977676489 modified "2023-09-27" @default.
• W1977676489 title "Differential tissue-on-tissue lubrication by ophthalmic formulations" @default.
• W1977676489 cites W1531288913 @default.
• W1977676489 cites W1978799932 @default.
• W1977676489 cites W1985677896 @default.
• W1977676489 cites W1990484681 @default.
• W1977676489 cites W1991163113 @default.
• W1977676489 cites W1992239553 @default.
• W1977676489 cites W2000902804 @default.
• W1977676489 cites W2012185184 @default.
• W1977676489 cites W2017137055 @default.
• W1977676489 cites W2017932469 @default.
• W1977676489 cites W2019995870 @default.
• W1977676489 cites W2027676888 @default.
• W1977676489 cites W2035730225 @default.
• W1977676489 cites W2038289365 @default.
• W1977676489 cites W2043606727 @default.
• W1977676489 cites W2075690706 @default.
• W1977676489 cites W2089719474 @default.
• W1977676489 cites W2096420560 @default.
• W1977676489 cites W2107313677 @default.
• W1977676489 cites W2117868751 @default.
• W1977676489 cites W2119121725 @default.
• W1977676489 cites W2127460898 @default.
• W1977676489 cites W2131504129 @default.
• W1977676489 cites W2156293851 @default.
• W1977676489 cites W2159486073 @default.
• W1977676489 cites W2167406387 @default.
• W1977676489 cites W2483066629 @default.
• W1977676489 doi "https://doi.org/10.1002/jbm.b.30707" @default.
• W1977676489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17078081" @default.
• W1977676489 hasPublicationYear "2007" @default.
• W1977676489 type Work @default.
• W1977676489 sameAs 1977676489 @default.
• W1977676489 citedByCount "14" @default.
• W1977676489 countsByYear W19776764892012 @default.
• W1977676489 countsByYear W19776764892014 @default.
• W1977676489 countsByYear W19776764892015 @default.
• W1977676489 countsByYear W19776764892016 @default.
• W1977676489 countsByYear W19776764892018 @default.
• W1977676489 countsByYear W19776764892020 @default.
• W1977676489 countsByYear W19776764892022 @default.
• W1977676489 countsByYear W19776764892023 @default.
• W1977676489 crossrefType "journal-article" @default.
• W1977676489 hasAuthorship W1977676489A5001043748 @default.
• W1977676489 hasAuthorship W1977676489A5008689600 @default.
• W1977676489 hasAuthorship W1977676489A5030141577 @default.
• W1977676489 hasAuthorship W1977676489A5054512056 @default.
• W1977676489 hasConcept C127413603 @default.
• W1977676489 hasConcept C134018914 @default.
• W1977676489 hasConcept C136229726 @default.
• W1977676489 hasConcept C159985019 @default.
• W1977676489 hasConcept C184608416 @default.
• W1977676489 hasConcept C192562407 @default.
• W1977676489 hasConcept C2776964284 @default.
• W1977676489 hasConcept C2777397205 @default.
• W1977676489 hasConcept C42360764 @default.
• W1977676489 hasConcept C71924100 @default.
• W1977676489 hasConceptScore W1977676489C127413603 @default.
• W1977676489 hasConceptScore W1977676489C134018914 @default.
• W1977676489 hasConceptScore W1977676489C136229726 @default.
• W1977676489 hasConceptScore W1977676489C159985019 @default.
• W1977676489 hasConceptScore W1977676489C184608416 @default.
• W1977676489 hasConceptScore W1977676489C192562407 @default.
• W1977676489 hasConceptScore W1977676489C2776964284 @default.
• W1977676489 hasConceptScore W1977676489C2777397205 @default.
• W1977676489 hasConceptScore W1977676489C42360764 @default.
• W1977676489 hasConceptScore W1977676489C71924100 @default.
• W1977676489 hasIssue "1" @default.
• W1977676489 hasLocation W19776764891 @default.
• W1977676489 hasLocation W19776764892 @default.
• W1977676489 hasOpenAccess W1977676489 @default.
• W1977676489 hasPrimaryLocation W19776764891 @default.
• W1977676489 hasRelatedWork W1994103032 @default.
• W1977676489 hasRelatedWork W2051270029 @default.
• W1977676489 hasRelatedWork W2082293200 @default.
• W1977676489 hasRelatedWork W2137307547 @default.
• W1977676489 hasRelatedWork W2380293314 @default.
• W1977676489 hasRelatedWork W2943188944 @default.
• W1977676489 hasRelatedWork W3008690834 @default.
• W1977676489 hasRelatedWork W4242480814 @default.
• W1977676489 hasRelatedWork W4285802202 @default.
• W1977676489 hasRelatedWork W4317433637 @default.
• W1977676489 hasVolume "82B" @default.
• W1977676489 isParatext "false" @default.
• W1977676489 isRetracted "false" @default.
• W1977676489 magId "1977676489" @default.
• W1977676489 workType "article" @default.