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- W1977683420 abstract "The mismatch negativity (MMN) is thought to index the activation of specialized neural networks for active prediction and deviance detection. However, a detailed neuronal model of the neurobiological mechanisms underlying the MMN is still lacking, and its computational foundations remain debated. We propose here a detailed neuronal model of auditory cortex, based on predictive coding, that accounts for the critical features of MMN. The model is entirely composed of spiking excitatory and inhibitory neurons interconnected in a layered cortical architecture with distinct input, predictive, and prediction error units. A spike-timing dependent learning rule, relying upon NMDA receptor synaptic transmission, allows the network to adjust its internal predictions and use a memory of the recent past inputs to anticipate on future stimuli based on transition statistics. We demonstrate that this simple architecture can account for the major empirical properties of the MMN. These include a frequency-dependent response to rare deviants, a response to unexpected repeats in alternating sequences (ABABAA…), a lack of consideration of the global sequence context, a response to sound omission, and a sensitivity of the MMN to NMDA receptor antagonists. Novel predictions are presented, and a new magnetoencephalography experiment in healthy human subjects is presented that validates our key hypothesis: the MMN results from active cortical prediction rather than passive synaptic habituation." @default.
- W1977683420 created "2016-06-24" @default.
- W1977683420 creator A5045261969 @default.
- W1977683420 creator A5075892407 @default.
- W1977683420 creator A5091872846 @default.
- W1977683420 date "2012-03-14" @default.
- W1977683420 modified "2023-10-14" @default.
- W1977683420 title "A Neuronal Model of Predictive Coding Accounting for the Mismatch Negativity" @default.
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- W1977683420 cites W1968600772 @default.
- W1977683420 cites W1974840272 @default.
- W1977683420 cites W1975141160 @default.
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- W1977683420 cites W1983583284 @default.
- W1977683420 cites W1994044313 @default.
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- W1977683420 cites W2001921661 @default.
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- W1977683420 cites W2016554514 @default.
- W1977683420 cites W2017040534 @default.
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- W1977683420 doi "https://doi.org/10.1523/jneurosci.5003-11.2012" @default.
- W1977683420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6703454" @default.
- W1977683420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22423089" @default.
- W1977683420 hasPublicationYear "2012" @default.
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