FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977686336> ?p ?o ?g. }

• W1977686336 endingPage "27" @default.
• W1977686336 startingPage "21" @default.
• W1977686336 abstract "The gene hclB encodes a histamine-gated chloride channel subunit in Drosophila melanogaster. Mutations in hclB lead to defects in the visual system and altered sensitivity to the action of ivermectin. To investigate whether this member of the Cys-loop receptors is common across the Insecta, we analysed the genomes of seven other insect species (Diptera, Hymenoptera, Coleoptera) and revealed orthologues of hclB in all of them. Sequence comparisons showed high identity levels between the orthologues, indicating similar constraints and conserved function between the species. Two D. melanogaster mutants, hclB(T1) (P293S) and hclB(T2) (W111*, a null mutation) were tested for the lapse into, and recovery from, paralysis induced by high temperature or the anaesthetic action of halothane. At 41 degrees C, the hclB(T2) flies lapsed into coma faster than wild-type or the hclB(T1) flies, while both mutants recovered more slowly. A substantially impaired recovery rate was also observed in hclB(T1) after anaesthesia with halothane. Enhanced synaptic signalling at low-intensity light stimuli was registered on electroretinograms recorded from the two mutant strains. Our results suggest that HCLB may play an essential and conserved role in insect neurophysiology." @default.
• W1977686336 created "2016-06-24" @default.
• W1977686336 creator A5002671910 @default.
• W1977686336 creator A5025342051 @default.
• W1977686336 creator A5053039267 @default.
• W1977686336 date "2010-01-01" @default.
• W1977686336 modified "2023-09-27" @default.
• W1977686336 title "Functional consequences of mutations in the Drosophila histamine receptor HCLB" @default.
• W1977686336 cites W1505693447 @default.
• W1977686336 cites W1840025613 @default.
• W1977686336 cites W196651220 @default.
• W1977686336 cites W1967904317 @default.
• W1977686336 cites W1979606761 @default.
• W1977686336 cites W1984095012 @default.
• W1977686336 cites W1993984710 @default.
• W1977686336 cites W2021821361 @default.
• W1977686336 cites W2024852738 @default.
• W1977686336 cites W2036876463 @default.
• W1977686336 cites W2048530738 @default.
• W1977686336 cites W2060287150 @default.
• W1977686336 cites W2062922299 @default.
• W1977686336 cites W2067987331 @default.
• W1977686336 cites W2070153004 @default.
• W1977686336 cites W2079250067 @default.
• W1977686336 cites W2079353889 @default.
• W1977686336 cites W2088814430 @default.
• W1977686336 cites W2089106070 @default.
• W1977686336 cites W2095947640 @default.
• W1977686336 cites W2098562669 @default.
• W1977686336 cites W2099504291 @default.
• W1977686336 cites W2104469205 @default.
• W1977686336 cites W2107971067 @default.
• W1977686336 cites W2108893201 @default.
• W1977686336 cites W2117983072 @default.
• W1977686336 cites W2121685385 @default.
• W1977686336 cites W2122767334 @default.
• W1977686336 cites W2146025280 @default.
• W1977686336 cites W2152052384 @default.
• W1977686336 cites W2159307108 @default.
• W1977686336 doi "https://doi.org/10.1016/j.jinsphys.2009.08.016" @default.
• W1977686336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2805722" @default.
• W1977686336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19716373" @default.
• W1977686336 hasPublicationYear "2010" @default.
• W1977686336 type Work @default.
• W1977686336 sameAs 1977686336 @default.
• W1977686336 citedByCount "10" @default.
• W1977686336 countsByYear W19776863362012 @default.
• W1977686336 countsByYear W19776863362013 @default.
• W1977686336 countsByYear W19776863362018 @default.
• W1977686336 countsByYear W19776863362019 @default.
• W1977686336 countsByYear W19776863362022 @default.
• W1977686336 countsByYear W19776863362023 @default.
• W1977686336 crossrefType "journal-article" @default.
• W1977686336 hasAuthorship W1977686336A5002671910 @default.
• W1977686336 hasAuthorship W1977686336A5025342051 @default.
• W1977686336 hasAuthorship W1977686336A5053039267 @default.
• W1977686336 hasBestOaLocation W19776863361 @default.
• W1977686336 hasConcept C104317684 @default.
• W1977686336 hasConcept C1122143 @default.
• W1977686336 hasConcept C143065580 @default.
• W1977686336 hasConcept C170493617 @default.
• W1977686336 hasConcept C2775864247 @default.
• W1977686336 hasConcept C2776998849 @default.
• W1977686336 hasConcept C2777612826 @default.
• W1977686336 hasConcept C2780104201 @default.
• W1977686336 hasConcept C2780696224 @default.
• W1977686336 hasConcept C54355233 @default.
• W1977686336 hasConcept C59822182 @default.
• W1977686336 hasConcept C86803240 @default.
• W1977686336 hasConcept C95444343 @default.
• W1977686336 hasConcept C98274493 @default.
• W1977686336 hasConceptScore W1977686336C104317684 @default.
• W1977686336 hasConceptScore W1977686336C1122143 @default.
• W1977686336 hasConceptScore W1977686336C143065580 @default.
• W1977686336 hasConceptScore W1977686336C170493617 @default.
• W1977686336 hasConceptScore W1977686336C2775864247 @default.
• W1977686336 hasConceptScore W1977686336C2776998849 @default.
• W1977686336 hasConceptScore W1977686336C2777612826 @default.
• W1977686336 hasConceptScore W1977686336C2780104201 @default.
• W1977686336 hasConceptScore W1977686336C2780696224 @default.
• W1977686336 hasConceptScore W1977686336C54355233 @default.
• W1977686336 hasConceptScore W1977686336C59822182 @default.
• W1977686336 hasConceptScore W1977686336C86803240 @default.
• W1977686336 hasConceptScore W1977686336C95444343 @default.
• W1977686336 hasConceptScore W1977686336C98274493 @default.
• W1977686336 hasIssue "1" @default.
• W1977686336 hasLocation W19776863361 @default.
• W1977686336 hasLocation W19776863362 @default.
• W1977686336 hasLocation W19776863363 @default.
• W1977686336 hasLocation W19776863364 @default.
• W1977686336 hasOpenAccess W1977686336 @default.
• W1977686336 hasPrimaryLocation W19776863361 @default.
• W1977686336 hasRelatedWork W1895436009 @default.
• W1977686336 hasRelatedWork W1969421403 @default.
• W1977686336 hasRelatedWork W2037025856 @default.
• W1977686336 hasRelatedWork W2142669469 @default.
• W1977686336 hasRelatedWork W2148375889 @default.
• W1977686336 hasRelatedWork W2579125832 @default.

• next