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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977702903> ?p ?o ?g. }

• W1977702903 endingPage "794" @default.
• W1977702903 startingPage "786" @default.
• W1977702903 abstract "We investigated the origin of the glomerular mesangial cell, a smooth muscle-like cell that provides structural support in the glomerulus. Injection of anti-Thy 1 antibody that binds the Thy 1 antigen on rat mesangial cells eliminated (> 95%) the mesangial population at 20-28 h, while Thy 1-positive cells in the juxtaglomerular apparatus (JGA) were sequestered from the circulation and survived. Single pulse labeling with [3H]thymidine at 36 h labeled Thy 1-positive cells in the JGA and hilus. Serial biopsies demonstrated the progressive migration (5-15 micron/d) and proliferation of these mesangial reserve cells until the entire glomerulus was repopulated. The regenerating mesangial population expressed contractile and migratory proteins preferentially at the leading edge of the migratory front. Single as well as multiple pulse labeling with [3H]thymidine confirmed that the entire mesangial cell repopulation originated from only a few mesangial reserve cells. These reserve cells resided in the extraglomerular mesangium in the JGA and were not renin-secreting cells, macrophages, smooth muscle cells, or endothelial cells. These studies document mesangial cell migration in the anti-Thy 1 model of mesangial proliferative glomerulonephritis and provide evidence for a new role for the juxtaglomerular apparatus in the maintenance of the mesangial cell population." @default.
• W1977702903 created "2016-06-24" @default.
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• W1977702903 date "1997-08-15" @default.
• W1977702903 modified "2023-10-14" @default.
• W1977702903 title "Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus." @default.
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• W1977702903 doi "https://doi.org/10.1172/jci119592" @default.
• W1977702903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/508249" @default.
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