Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977704353> ?p ?o ?g. }
- W1977704353 endingPage "14105" @default.
- W1977704353 startingPage "14105" @default.
- W1977704353 abstract "Irritable bowel syndrome (IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions." @default.
- W1977704353 created "2016-06-24" @default.
- W1977704353 creator A5052377220 @default.
- W1977704353 date "2014-01-01" @default.
- W1977704353 modified "2023-10-16" @default.
- W1977704353 title "Irritable bowel syndrome: A microbiome-gut-brain axis disorder?" @default.
- W1977704353 cites W1483779359 @default.
- W1977704353 cites W1490861410 @default.
- W1977704353 cites W1527298303 @default.
- W1977704353 cites W1531709512 @default.
- W1977704353 cites W1566099765 @default.
- W1977704353 cites W1579866483 @default.
- W1977704353 cites W1605188970 @default.
- W1977704353 cites W1670958367 @default.
- W1977704353 cites W1822193713 @default.
- W1977704353 cites W1920510593 @default.
- W1977704353 cites W1931452900 @default.
- W1977704353 cites W1943214522 @default.
- W1977704353 cites W1958125164 @default.
- W1977704353 cites W1964244234 @default.
- W1977704353 cites W1965487992 @default.
- W1977704353 cites W1965814102 @default.
- W1977704353 cites W1966217983 @default.
- W1977704353 cites W1966470298 @default.
- W1977704353 cites W1966691836 @default.
- W1977704353 cites W1967990741 @default.
- W1977704353 cites W1968105193 @default.
- W1977704353 cites W1968294128 @default.
- W1977704353 cites W1968646392 @default.
- W1977704353 cites W1968888153 @default.
- W1977704353 cites W1969615942 @default.
- W1977704353 cites W1972017802 @default.
- W1977704353 cites W1972978634 @default.
- W1977704353 cites W1974577714 @default.
- W1977704353 cites W1975600873 @default.
- W1977704353 cites W1976582565 @default.
- W1977704353 cites W1980572807 @default.
- W1977704353 cites W1980848546 @default.
- W1977704353 cites W1981500982 @default.
- W1977704353 cites W1982367189 @default.
- W1977704353 cites W1982475747 @default.
- W1977704353 cites W1983350548 @default.
- W1977704353 cites W1983814959 @default.
- W1977704353 cites W1984630897 @default.
- W1977704353 cites W1985543793 @default.
- W1977704353 cites W1986035779 @default.
- W1977704353 cites W1987981979 @default.
- W1977704353 cites W1988999476 @default.
- W1977704353 cites W1989675129 @default.
- W1977704353 cites W1990075521 @default.
- W1977704353 cites W1992611765 @default.
- W1977704353 cites W1993623582 @default.
- W1977704353 cites W1995417833 @default.
- W1977704353 cites W1998253541 @default.
- W1977704353 cites W1999221921 @default.
- W1977704353 cites W1999907967 @default.
- W1977704353 cites W2000275267 @default.
- W1977704353 cites W2002519510 @default.
- W1977704353 cites W2002633363 @default.
- W1977704353 cites W2002703043 @default.
- W1977704353 cites W2002811300 @default.
- W1977704353 cites W2004740947 @default.
- W1977704353 cites W2005092419 @default.
- W1977704353 cites W2005578275 @default.
- W1977704353 cites W2006830302 @default.
- W1977704353 cites W2006914459 @default.
- W1977704353 cites W2007115125 @default.
- W1977704353 cites W2007788933 @default.
- W1977704353 cites W2009083997 @default.
- W1977704353 cites W2011914193 @default.
- W1977704353 cites W2012109410 @default.
- W1977704353 cites W2012312828 @default.
- W1977704353 cites W2012953866 @default.
- W1977704353 cites W2014385625 @default.
- W1977704353 cites W2016586816 @default.
- W1977704353 cites W2017418025 @default.
- W1977704353 cites W2017815964 @default.
- W1977704353 cites W2018578159 @default.
- W1977704353 cites W2019423369 @default.
- W1977704353 cites W2020365701 @default.
- W1977704353 cites W2020783130 @default.
- W1977704353 cites W2021385518 @default.
- W1977704353 cites W2022625286 @default.
- W1977704353 cites W2023858375 @default.
- W1977704353 cites W2024107091 @default.
- W1977704353 cites W2024601462 @default.
- W1977704353 cites W2024712346 @default.
- W1977704353 cites W2024859421 @default.
- W1977704353 cites W2028507955 @default.
- W1977704353 cites W2028890830 @default.
- W1977704353 cites W2029071453 @default.
- W1977704353 cites W2029073712 @default.
- W1977704353 cites W2030108859 @default.
- W1977704353 cites W2030261917 @default.
- W1977704353 cites W2030322777 @default.
- W1977704353 cites W2030500910 @default.
- W1977704353 cites W203076350 @default.
- W1977704353 cites W2030842783 @default.