Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977707788> ?p ?o ?g. }
- W1977707788 endingPage "209" @default.
- W1977707788 startingPage "205" @default.
- W1977707788 abstract "Background There are few articles on mortality and morbidity of adult patients with Eisenmenger's syndrome (ES) in the current era when disease targeting therapy (DTT) has been available. Methods and results 198 patients (a median age 35 years, 64% female) with ES who visited the 16 participating institutes in Japan and Korea from 1998 to 2009 were enrolled. Clinical data during adulthood were collected from each institutional chart and analyzed centrally. During a median follow-up of 8 years, 30 patients died including 14 sudden deaths. 89 patients took oral medication of DTT and clinical improvement was observed in 54 of them. However, survival rate in patients taking DTT was not different from those without (87% vs 84%, p=0.55). When the clinical data in between first and last clinic visits were compared in 85 patients, the patients with NYHA ≧ III increased from 24% to 48% (p<0.001), SpO2 decreased from 89% to 85% (p=0.008) and hematocrit increased from 51.4% to 52.9% (p=0.04). Non-survivors had poorer NYHA function class, lower body weight (BW), lower body mass index (BMI), and higher serum level of Cr at the first visits than survivors. Conclusions Long term survival and clinical status of adult patients with ES remains unsatisfactory even in the current era of DTT. Poor NYHA functional class, low BW, low BMI and high serum level of Cr were related to mortality. DTT therapy improved clinical status in many patients with Eisenmenger's syndrome, but no significant impact on survival could be shown." @default.
- W1977707788 created "2016-06-24" @default.
- W1977707788 creator A5001618823 @default.
- W1977707788 creator A5002734140 @default.
- W1977707788 creator A5004869014 @default.
- W1977707788 creator A5005191910 @default.
- W1977707788 creator A5017835654 @default.
- W1977707788 creator A5019068702 @default.
- W1977707788 creator A5020045841 @default.
- W1977707788 creator A5024749024 @default.
- W1977707788 creator A5026563765 @default.
- W1977707788 creator A5027043087 @default.
- W1977707788 creator A5029121458 @default.
- W1977707788 creator A5033857302 @default.
- W1977707788 creator A5038034531 @default.
- W1977707788 creator A5040364071 @default.
- W1977707788 creator A5041412600 @default.
- W1977707788 creator A5045977893 @default.
- W1977707788 creator A5067970141 @default.
- W1977707788 creator A5074508104 @default.
- W1977707788 creator A5076373651 @default.
- W1977707788 creator A5078188464 @default.
- W1977707788 creator A5089160532 @default.
- W1977707788 creator A5089370906 @default.
- W1977707788 date "2013-07-01" @default.
- W1977707788 modified "2023-09-27" @default.
- W1977707788 title "Clinical features of adult patients with Eisenmenger's syndrome in Japan and Korea" @default.
- W1977707788 cites W151074863 @default.
- W1977707788 cites W163933647 @default.
- W1977707788 cites W2001664528 @default.
- W1977707788 cites W2016336080 @default.
- W1977707788 cites W2019739355 @default.
- W1977707788 cites W2020973304 @default.
- W1977707788 cites W2027227731 @default.
- W1977707788 cites W2036778075 @default.
- W1977707788 cites W2051159212 @default.
- W1977707788 cites W2063837517 @default.
- W1977707788 cites W2072382359 @default.
- W1977707788 cites W2074042973 @default.
- W1977707788 cites W2103925343 @default.
- W1977707788 cites W2108055336 @default.
- W1977707788 cites W2111322809 @default.
- W1977707788 cites W2114617816 @default.
- W1977707788 cites W2121538692 @default.
- W1977707788 cites W2121842052 @default.
- W1977707788 cites W2127994875 @default.
- W1977707788 cites W2139103416 @default.
- W1977707788 cites W2139468075 @default.
- W1977707788 cites W2148934940 @default.
- W1977707788 cites W2158657788 @default.
- W1977707788 cites W2159068151 @default.
- W1977707788 cites W2163585396 @default.
- W1977707788 cites W4248712611 @default.
- W1977707788 doi "https://doi.org/10.1016/j.ijcard.2011.12.030" @default.
- W1977707788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22227251" @default.
- W1977707788 hasPublicationYear "2013" @default.
- W1977707788 type Work @default.
- W1977707788 sameAs 1977707788 @default.
- W1977707788 citedByCount "5" @default.
- W1977707788 countsByYear W19777077882013 @default.
- W1977707788 countsByYear W19777077882014 @default.
- W1977707788 countsByYear W19777077882015 @default.
- W1977707788 countsByYear W19777077882018 @default.
- W1977707788 crossrefType "journal-article" @default.
- W1977707788 hasAuthorship W1977707788A5001618823 @default.
- W1977707788 hasAuthorship W1977707788A5002734140 @default.
- W1977707788 hasAuthorship W1977707788A5004869014 @default.
- W1977707788 hasAuthorship W1977707788A5005191910 @default.
- W1977707788 hasAuthorship W1977707788A5017835654 @default.
- W1977707788 hasAuthorship W1977707788A5019068702 @default.
- W1977707788 hasAuthorship W1977707788A5020045841 @default.
- W1977707788 hasAuthorship W1977707788A5024749024 @default.
- W1977707788 hasAuthorship W1977707788A5026563765 @default.
- W1977707788 hasAuthorship W1977707788A5027043087 @default.
- W1977707788 hasAuthorship W1977707788A5029121458 @default.
- W1977707788 hasAuthorship W1977707788A5033857302 @default.
- W1977707788 hasAuthorship W1977707788A5038034531 @default.
- W1977707788 hasAuthorship W1977707788A5040364071 @default.
- W1977707788 hasAuthorship W1977707788A5041412600 @default.
- W1977707788 hasAuthorship W1977707788A5045977893 @default.
- W1977707788 hasAuthorship W1977707788A5067970141 @default.
- W1977707788 hasAuthorship W1977707788A5074508104 @default.
- W1977707788 hasAuthorship W1977707788A5076373651 @default.
- W1977707788 hasAuthorship W1977707788A5078188464 @default.
- W1977707788 hasAuthorship W1977707788A5089160532 @default.
- W1977707788 hasAuthorship W1977707788A5089370906 @default.
- W1977707788 hasConcept C126322002 @default.
- W1977707788 hasConcept C187212893 @default.
- W1977707788 hasConcept C2779249879 @default.
- W1977707788 hasConcept C2780074459 @default.
- W1977707788 hasConcept C2780221984 @default.
- W1977707788 hasConcept C71924100 @default.
- W1977707788 hasConceptScore W1977707788C126322002 @default.
- W1977707788 hasConceptScore W1977707788C187212893 @default.
- W1977707788 hasConceptScore W1977707788C2779249879 @default.
- W1977707788 hasConceptScore W1977707788C2780074459 @default.
- W1977707788 hasConceptScore W1977707788C2780221984 @default.
- W1977707788 hasConceptScore W1977707788C71924100 @default.