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- W1977715087 abstract "IL-10R2 is a shared cell surface receptor required for the activation of five class 2 cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) that play critical roles in host defense. To define the molecular mechanisms that regulate its promiscuous binding, we have determined the crystal structure of the IL-10R2 ectodomain at 2.14 A resolution. IL-10R2 residues required for binding were identified by alanine scanning and used to derive computational models of IL-10/IL-10R1/IL-10R2 and IL-22/IL-22R1/IL-10R2 ternary complexes. The models reveal a conserved binding epitope that is surrounded by two clefts that accommodate the structural and chemical diversity of the cytokines. These results provide a structural framework for interpreting IL-10R2 single nucleotide polymorphisms associated with human disease." @default.
- W1977715087 created "2016-06-24" @default.
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- W1977715087 date "2010-05-01" @default.
- W1977715087 modified "2023-10-13" @default.
- W1977715087 title "Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain" @default.
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- W1977715087 cites W1965277349 @default.
- W1977715087 cites W1965851103 @default.
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- W1977715087 doi "https://doi.org/10.1016/j.str.2010.02.009" @default.
- W1977715087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2879597" @default.
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