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• W1977715526 abstract "Interleukin 21 (IL-21) is a pleiotropic cytokine produced by CD4 T cells that affects the differentiation and function of T, B, and NK cells by binding to a receptor consisting of the common cytokine receptor γ chain and the IL-21 receptor (IL-21R). IL-21, a product associated with IL-17-producing CD4 T cells (T H 17) and follicular CD4 T helper cells (T FH ), has been implicated in autoimmune disorders including the severe systemic lupus erythematosus (SLE)-like disease characteristic of BXSB- Yaa mice. To determine whether IL-21 plays a significant role in this disease, we compared IL-21R-deficient and -competent BXSB- Yaa mice for multiple parameters of SLE. The deficient mice showed none of the abnormalities characteristic of SLE in IL-21R-competent Yaa mice, including hypergammaglobulinemia, autoantibody production, reduced frequencies of marginal zone B cells and monocytosis, renal disease, and premature morbidity. IL-21 production associated with this autoimmune disease was not a product of T H 17 cells and was not limited to conventional CXCR5 + T FH but instead was produced broadly by ICOS + CD4 + splenic T cells. IL-21 arising from an abnormal population of CD4 T cells is thus central to the development of this lethal disease, and, more generally, could play an important role in human SLE and related autoimmune disorders." @default.
• W1977715526 created "2016-06-24" @default.
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• W1977715526 date "2009-02-03" @default.
• W1977715526 modified "2023-10-03" @default.
• W1977715526 title "A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB- <i>Yaa</i> mice" @default.
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• W1977715526 doi "https://doi.org/10.1073/pnas.0807309106" @default.
• W1977715526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2635818" @default.
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