Matches in SemOpenAlex for { <https://semopenalex.org/work/W1977748711> ?p ?o ?g. }
- W1977748711 endingPage "3435" @default.
- W1977748711 startingPage "3423" @default.
- W1977748711 abstract "Kinins are synthesized from their precursors by different enzymes and participate in the regulation of cardiovascular function through bradykinin (BK) B1 and B2 receptors. They modulate blood coagulation by exerting antithrombotic and profibrinolytic actions. By activating B2 receptors that results in the release of nitric oxide and prostacyclin, kinins inhibit vascular smooth muscle growth and neointima formation, which may play an inhibitory role on the atherosclerosis development, while through the activation of B1 receptors, they may play a deleterious role in this disease. Kinins are potent endogenous vasodilators that are involved in the regulation of coronary vascular tone. However, due to their metabolic characteristics, these peptides act mainly as an autocrine/paracrine factor to locally regulate blood perfusion of organs. By modulating cellular energy metabolism and myocardial oxygen consumption, they protect cardiac and vascular endothelial function in myocardial ischemia and heart failure. Finally, mounting evidence indicates that kinins are involved in the actions of some drugs actually used in the treatment of cardiovascular diseases such as angiotensin-converting enzyme inhibitors and angiotensin AT1 receptor antagonists. Taken together, the kinin system constitutes a potential therapeutic target for cardiovascular diseases. Experiments in animals attempted to explore the kinin system as a therapeutic means, including the mobilization of endogenous kinins using pharmacological agents, searching BK analogs with long-acting properties and gene therapies. However, the potential values of the kinin system have not been taken into consideration in clinical practice for cardiovascular indications." @default.
- W1977748711 created "2016-06-24" @default.
- W1977748711 creator A5007644743 @default.
- W1977748711 date "2006-09-01" @default.
- W1977748711 modified "2023-10-13" @default.
- W1977748711 title "Kinins and Cardiovascular Diseases" @default.
- W1977748711 cites W1505408758 @default.
- W1977748711 cites W1533112727 @default.
- W1977748711 cites W1542840309 @default.
- W1977748711 cites W1598488379 @default.
- W1977748711 cites W1734562766 @default.
- W1977748711 cites W1764686129 @default.
- W1977748711 cites W1905600998 @default.
- W1977748711 cites W1944100455 @default.
- W1977748711 cites W1964363992 @default.
- W1977748711 cites W1966406818 @default.
- W1977748711 cites W1966637576 @default.
- W1977748711 cites W1966726026 @default.
- W1977748711 cites W1966939913 @default.
- W1977748711 cites W1968948768 @default.
- W1977748711 cites W1969138559 @default.
- W1977748711 cites W1970479811 @default.
- W1977748711 cites W1971122576 @default.
- W1977748711 cites W1971308616 @default.
- W1977748711 cites W1971923625 @default.
- W1977748711 cites W1972581901 @default.
- W1977748711 cites W1975926637 @default.
- W1977748711 cites W1976063852 @default.
- W1977748711 cites W1976408724 @default.
- W1977748711 cites W1976850283 @default.
- W1977748711 cites W1978117668 @default.
- W1977748711 cites W1978221784 @default.
- W1977748711 cites W1978985584 @default.
- W1977748711 cites W1979250205 @default.
- W1977748711 cites W1979615536 @default.
- W1977748711 cites W1981224843 @default.
- W1977748711 cites W1981594756 @default.
- W1977748711 cites W1982980177 @default.
- W1977748711 cites W1983505487 @default.
- W1977748711 cites W1983924502 @default.
- W1977748711 cites W1986905765 @default.
- W1977748711 cites W1987637136 @default.
- W1977748711 cites W1987664769 @default.
- W1977748711 cites W1988453293 @default.
- W1977748711 cites W1988500109 @default.
- W1977748711 cites W1988592848 @default.
- W1977748711 cites W1991092240 @default.
- W1977748711 cites W1993135641 @default.
- W1977748711 cites W1998873687 @default.
- W1977748711 cites W2000555366 @default.
- W1977748711 cites W2001224237 @default.
- W1977748711 cites W2002717483 @default.
- W1977748711 cites W2003731113 @default.
- W1977748711 cites W2004472687 @default.
- W1977748711 cites W2004992040 @default.
- W1977748711 cites W2006938020 @default.
- W1977748711 cites W2007129904 @default.
- W1977748711 cites W2009150846 @default.
- W1977748711 cites W2009890346 @default.
- W1977748711 cites W2010031713 @default.
- W1977748711 cites W2011021180 @default.
- W1977748711 cites W2012252766 @default.
- W1977748711 cites W2013229061 @default.
- W1977748711 cites W2013813492 @default.
- W1977748711 cites W2015287231 @default.
- W1977748711 cites W2016476063 @default.
- W1977748711 cites W2016550483 @default.
- W1977748711 cites W2019114393 @default.
- W1977748711 cites W2021891143 @default.
- W1977748711 cites W2022321345 @default.
- W1977748711 cites W2022919113 @default.
- W1977748711 cites W2025530554 @default.
- W1977748711 cites W2026234800 @default.
- W1977748711 cites W2026826353 @default.
- W1977748711 cites W2028145191 @default.
- W1977748711 cites W2028681689 @default.
- W1977748711 cites W2029967055 @default.
- W1977748711 cites W2030836837 @default.
- W1977748711 cites W2032647797 @default.
- W1977748711 cites W2032659410 @default.
- W1977748711 cites W2034004569 @default.
- W1977748711 cites W2036096478 @default.
- W1977748711 cites W2040848338 @default.
- W1977748711 cites W2041075406 @default.
- W1977748711 cites W2041623885 @default.
- W1977748711 cites W2041747627 @default.
- W1977748711 cites W2041834967 @default.
- W1977748711 cites W2041986157 @default.
- W1977748711 cites W2043278159 @default.
- W1977748711 cites W2043294730 @default.
- W1977748711 cites W2048425485 @default.
- W1977748711 cites W2048547503 @default.
- W1977748711 cites W2049579566 @default.
- W1977748711 cites W2051921599 @default.
- W1977748711 cites W2053329983 @default.
- W1977748711 cites W2054550385 @default.
- W1977748711 cites W2058399305 @default.
- W1977748711 cites W2058755393 @default.